Analysis of the mechanism and appropriate therapy of persistent atrial fibrillation

• Project/Area Number: 24591061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: YAMABE Hiroshige 熊本大学, 医学部附属病院, 教授 (20419641)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 持続性心房細動 / マッピング / カテーテルアブレーション / 心房細動

Outline of Final Research Achievements

Persistent atrial fibrillation was maintained by the disorganized activation, which was mainly observed over the complex fractionated electrogram (CFAE) region. The CFAE area was caused by the heterogeneous conduction property of the left atrial myocardium and was closely associated with the cardiac pericardial fat tissue. Linear left atrial roof lesion and subsequent CFAE ablation after the pulmonary vein isolation performed in a stepwise fashion was effective for the termination of persistent atrial fibrillation.

Research Products

• [Journal Article] Left atrial electrophysiologic feature specific for the genesis of complex fractionated atrial electrogram during atrial fibrillation. (2015)
  • Author(s): 星山禎
  • Journal Title: Heart Vessels. Volume: in press
  • Peer Reviewed
• [Journal Article] Importance of pericardial fat in the formation of complex fractionated atrial electrogram region in atrial fibrillation. (2014)
  • Author(s): 金澤尚徳
  • Journal Title: Int J Cardiol Volume: 174 Pages: 557-564
  • Peer Reviewed
• [Presentation] Improvement of the Endothelial Function in Patients with Atrial Fibrillation: Effect of Sinus Rhythm Restoration by Catheter Ablation. (2014)
  • Author(s): 金澤尚徳
  • Organizer: 87th American Heart Association Scientific Sessions
  • Place of Presentation: Chicago,Illinois USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Superior Vena Cava as the Substrate of Various Forms of Atrial Tachyarrhythmias: Consideration into The Mechanism and Tachycardia Circuit. (2014)
  • Author(s): 山部浩茂
  • Organizer: 87th American Heart Association Scientific Sessions
  • Place of Presentation: Chicago,Illinois USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Analysis of the Primary Factor which Predicts the Incidence of Esophagus Ulceration Observed After Radiofrequency Catheter Ablation of Atrial Fibrillation. (2014)
  • Author(s): 伊藤美和
  • Organizer: 87th American Heart Association Scientific Sessions
  • Place of Presentation: Chicago,Illinois USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Stepwise Atrial Fibrillation Ablation Navigated by Non-Contact Mapping Performed After Pulmonary Vein Isolation: Comparison Between Paroxysmal and Persistent Atrial Fibrillation. (2013)
  • Author(s): 山部浩茂
  • Organizer: 86th American Heart Association Scientific Session
  • Place of Presentation: Dallas, TX, USA
• [Presentation] Mechanism of Termination of Random Wave Propagation by Ablation of Complex Fractionated Atrial Electrogram Region in Persistent Atrial Fibrillation: Three-dimensional Analysis Using Non-contact Mapping. (2013)
  • Author(s): 古山准二郎
  • Organizer: 86th American Heart Association Scientific Sessions
  • Place of Presentation: Dallas, TX, USA
• [Presentation] The Preferable Anatomical Location of the Rotational Reentrant Circuit in Patients With Atrial Fibrillation: Analysis by the Non-Contact Mapping. (2013)
  • Author(s): 星山禎
  • Organizer: 86th American Heart Association Scientific Sessions
  • Place of Presentation: Dallas, TX, USA
• [Presentation] Comparison of the Activation Sequence Between the Dominant Frequency Site and Complex Fractionated Atrial Electrograms Region Using Contact and Non-contact Mapping: Analysis of Their Role for the Maintenance of Atrial Fibrillation. (2013)
  • Author(s): 星山禎
  • Organizer: 86th American Heart Association Scientific Sessions
  • Place of Presentation: Dallas, TX, USA
• [Presentation] Stepwise Atrial Fibrillation Ablation Navigated by Non-contact Mapping Performed after Pulmonary Vein Isolation: Comparison between Paroxysmal and Persistent Atrial Fibrillation (2013)
  • Author(s): 山部浩茂
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Stationary Rotational Reentry Identified in Patients with Atrial Fibrillation by Non-contact Mapping: Mechanism and its Substrate (2012)
  • Author(s): 山部浩茂
  • Organizer: 85th Scientific Session of the American Heart Association
  • Place of Presentation: Los Angeles, CA, USA
• [Presentation] The Prefereble Anatomical Location of the Functional Conduction Block Line Preceded by the Onset of Random Meandering Reentrant Wave Propagation in Patients with Atrial Fibrillation: Analysis by the Non-Contact Mapping (2012)
  • Author(s): 星山禎
  • Organizer: 85th Scientific Session of the American Heart Association
  • Place of Presentation: Los Angeles, CA, USA
• [Presentation] Mechanism of the Electrogram Fractionation Observed in the Pulmonary Vein Antrum during Atrial Fibrillation: Analysis of Activation Using Contact and Non-Contact Mapping (2012)
  • Author(s): 古山准二郎
  • Organizer: 85th Scientific Session of the American Heart Association
  • Place of Presentation: Los Angeles, CA, USA