Rapid detection of CYP2C19 reduced-function gene polymorphism and the establishment of optimal medical therapy in patients with acute coronary syndrome

• Project/Area Number: 24591062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: KAIKITA Koichi 熊本大学, 医学部附属病院, 講師 (30346978)
• Research Collaborator: YOSHIMURA Hiromi 熊本大学, 医学教育部
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 循環器・高血圧 / 遺伝子 / 急性心筋梗塞 / 経皮的冠動脈ｲﾝﾀｰﾍﾞﾝｼｮﾝ / CYP2C19遺伝子多型 / クロピドグレル / 経皮的冠動脈インターベンション

Outline of Final Research Achievements

In patients with acute myocardial infarction undergoing emergent percutaneous coronary intervention, we investigated CYP2C19 gene variants by using Spartan RX DNA testing system, determined the dose of antiplatelet agents, and then examined the relation between on-clpidogrel platelet aggregation, the related biomarkers and the prognosis in those patients. We aimed for 150 patients as a prospective interventional study, and enrolled 108 patients as of April 2015. We plan to start data analysis after the measurement of the above-mentioned biomarkers is finished in all enrolled patients.

Research Products

• [Journal Article] Impact of CYP2C19 polymorphism on platelet function tests and coagulation and inflammatory biomarkers in patients undergoing percutaneous coronary intervention. (2014)
  • Author(s): Kaikita K (Corresponding author), Ono T, Iwashita S, Nakayama N, Sato K, Horio E, Nakamura S, Tsujita K, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Oshima S, Sugiyama S, Ogawa H.
  • Journal Title: J Atheroscler Thromb. Volume: 21 Pages: 64-76
  • NAID: 130004845456
  • Peer Reviewed
• [Journal Article] Clinical Features and Prognosis of Patients With Coronary Spasm Induced Non ST Segment Elevation Acute Coronary Syndrome. (2014)
  • Author(s): Nakayama N, Kaikita K, Fukunaga T, Matsuzawa Y, Sato K, Horio E, Yoshimura H, Mizobe M, Takashio S, Tsujita K, Kojima S, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Sugiyama S, Kimura K, Ogawa H.
  • Journal Title: Journal of the American Heart Association Volume: 3 Issue: 3
  • DOI: 10.1161/jaha.114.000795
  • Peer Reviewed / Open Access
• [Journal Article] Lack of association between peri-procedural myocardial damage and CYP2C19 gene variant in elective percutaneous coronary intervention. (2014)
  • Author(s): Yoshimura H, Kaikita K (Corresponding author), Ono T, Iwashita S, Nakayama N, Sato K, Horio E, Tsujita K, Kojima S, Tayama S, Hokimoto S, Ogawa H.
  • Journal Title: Heart Vessels. Volume: 0 Pages: 0-0
  • Peer Reviewed
• [Presentation] 冠攣縮における最新の話題 ‐冠攣縮薬物誘発試験を再考する‐ (2014)
  • Author(s): 海北幸一
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 宮城
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 日本のPCI治療における抗血小板療法の現状と展望 (2014)
  • Author(s): 海北幸一
  • Organizer: 第36回日本血栓止血学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-29 – 2014-05-31
• [Presentation] 遺伝子多型と抗血小板の効果 (2014)
  • Author(s): 海北幸一
  • Organizer: 第36回日本血栓止血学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-29 – 2014-05-31