| Project/Area Number |
24591064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEISHI Yasuchika 福島県立医科大学, 医学部, 教授 (40272067)
KUNII Hiroyuki 福島県立医科大学, 医学部, 助教 (20443856)
SAKAMOTO Nobuo 福島県立医科大学, 医学部, 助教 (80448638)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 急性冠症候群 / 早期診断 / バイオマーカー / 不安定プラーク |
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| Outline of Final Research Achievements |
As novel and useful biomarkers that may help in early diagnosis of acute coronary syndrome, neopterin, lectin-like oxidized LDL receptor-1 (LOX-1), tenascin C, CO hemoglobin, acrolein, RAGE (receptor for AGE: advanced glycation end products), and HMGB-1 (high mobility group box 1) were investigated.
The blood concentration of each substance, it was compared in acute coronary syndrome (acute myocardial infarction and unstable angina) and stable angina patients. Among them, blood levels of LOX-1 and tenascin C are significantly elevated in acute coronary syndrome patients, suggesting that they can help in early diagnosis of acute coronary syndrome.
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