The effect of cardiac rehabilitation on the myokines in patients with heart failura

• Project/Area Number: 24591066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka City University
• Principal Investigator: YOSHIYAMA Minoru 大阪市立大学, 医学(系)研究科(研究院), 教授 (30240956)
• Co-Investigator(Renkei-kenkyūsha): IZUMI Yasukatsu 大阪市立大学大学, 医学研究科, 准教授 (10347495) ; NAKAMURA Yasuhiro 大阪市立大学, 医学研究科, 登録医 (50457991)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心臓リハビリテーション / マイオカイン / 心血管保護効果 / 運動耐容能 / 慢性心不全 / 薬物療法 / 心臓リハビリ / 非薬物療法

Outline of Final Research Achievements

Exercise tolerance, not left ventricular ejection fraction, was important prognostic indicator for patients with chronic heart failure. Cardiac rehabilitation can prevent major cardiac adverse events. However, this mechanism is still unknown. Skeletal muscle has recently been identified as an organ that produces and releases cytokines, named “myokines.” We investigated whether serum brain derived neurotropic factor (BDNF) level or irisin, which is one of myokines, level at discharge could predict the prognosis in patients with heart failure (HF). This study consisted of patients who were hospitalized for worsening heart failure and had cardiac rehabilitation at least 1 week. We measured serum BNDF, and irisin. One-year follow-up was completed in all of the patients. Kaplan-Meier analysis demonstrated that the event free rate was decreased in the low BDNF or irisin group. Myokines level at discharge may be a useful biomarker for the prognosis in patients with HF.

Research Products

• [Journal Article] Percutaneous Carbon Dioxide Treatment using a Gas Mist Generator Enhances the Collateral Blood Flow in the Ischemic Hindlimb (2015)
  • Author(s): Izumi, Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 1 Pages: 38-51
  • DOI: 10.5551/jat.23770
  • NAID: 130004677973
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic patterns of the longitudinal and circumferential distribution of calcium deposits by parent coronary arteries observed from computed tomography angiography. (2015)
  • Author(s): 1.Ehara S, Matsumoto K, Hasegawa T, Otsuka K, Sakaguchi M, Shimada K, Yoshikawa J, Yoshiyama M.
  • Journal Title: Heart and Vessels Volume: 印刷中
• [Journal Article] Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction. (2015)
  • Author(s): Yamaguchi T, Izumi Y, Nakamura Y, Yamazaki T, Shiota M, Sano S, Tanaka M, Osada-Oka M, Shimada K, Miura K, Yoshiyama M, Iwao H.
  • Journal Title: Int J Cardiol Volume: 178 Pages: 239-246
• [Journal Article] Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography. (2014)
  • Author(s): Matsumura Y, Sugioka K, Fujita S, Ito A, Iwata S, Yoshiyama M.
  • Journal Title: Atherosclerosis Volume: 1 Pages: 301-306
• [Journal Article] Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters. (2014)
  • Author(s): Kato R, Nomura A, Sakamoto A, Yasuda Y, Amatani K, Nagai S, Sen Y, Ijiri Y, Okada Y, Yamaguchi T, Izumi Y, Yoshiyama M, Tanaka K, Hayashi T.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 307 Pages: 1626-1633
• [Journal Article] A noninvasive metabolic syndrome model using an extremely small minipig, the microminipig. (2014)
  • Author(s): Yamaguchi T, Yamazaki T, Kawaguchi H, Tawa M, Nakamura Y, Shiota M, Osada-Oka M, Tanimoto A, Okamura T, Miura K, Iwao H, Yoshiyama M, Izumi Y.
  • Journal Title: J Pharmacol Sci Volume: 126 Pages: 168-171
  • NAID: 130004690915
• [Journal Article] Relationship between CHADS2 score and complex aortic plaques by transesophageal echocardiography in patients with nonvalvular atrial fibrillation. (2014)
  • Author(s): Sugioka K, Fujita S, Iwata S, Ito A, Matsumura Y, Hanatani A, Doi A, Takagi M, Naruko T, Ueda M, Yoshiyama M.
  • Journal Title: Ultrasound Med Biol Volume: 40 Pages: 2358-2364
• [Journal Article] Serial assessment of arterial stiffness by cardio-ankle vascular index for prediction of future cardiovascular events in patients with coronary artery disease (2014)
  • Author(s): Otsuka, K
  • Journal Title: Hypertens Res Volume: 37 Issue: 11 Pages: 1014-1020
  • DOI: 10.1038/hr.2014.116
  • Peer Reviewed
• [Journal Article] Chronic active Epstein-Barr virus infection complicated with multiple artery aneurysms (2014)
  • Author(s): Nishimura S, Ehara S, Hanatani A, Yoshiyama M
  • Journal Title: Eur Heart J Cardiovsc Imaging Volume: 15 Issue: 11 Pages: 1255-1255
  • DOI: 10.1093/ehjci/jeu119
  • Peer Reviewed
• [Journal Article] Enhanced expression of hemoglobin scavenger receptor and heme oxygenase-1 is associated with aortic valve stenosis in patients undergoing hemodialysis. (2014)
  • Author(s): Inaba M, Sugioka K, Naruko T, Yunoki K, Kato Y, Shibata T, Inoue T, Ohsawa M, Yoshiyama M, Ueda M.
  • Journal Title: Hemodial Int Volume: 18 Issue: 3 Pages: 632-640
  • DOI: 10.1111/hdi.12147
  • Peer Reviewed
• [Journal Article] Giant mycotic coronary aneurysm associated with late stent infection. (2014)
  • Author(s): Nonin S, Hasegawa T, Hirai H, Suehiro S, Yoshiyama M.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 15 Issue: 6 Pages: 630-630
  • DOI: 10.1093/ehjci/jet262
• [Journal Article] Prognosis of vulnerable plaque on computed tomographic coronary angiography with normal myocardial perfusion image. (2014)
  • Author(s): Otsuka K, Fukuda S, Tanaka A, Nakanishi K, Taguchi H, Yoshiyama M, Shimada K, Yoshikawa J.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 15 Issue: 3 Pages: 332-340
  • DOI: 10.1093/ehjci/jet232
• [Journal Article] The strain pattern, and not Sokolow-Lyon electrocardiographic voltage criteria, is independently associated with anatomic left ventricular hypertrophy (2014)
  • Author(s): Ehara S, Hasegawa T, Matsumoto K, OtsukaY, Yamazaki T, Iguchi T, Izumi Y, Shimada K, Yoshiyama M
  • Journal Title: Heart Vessels Volume: 29 Issue: 5 Pages: 638-644
  • DOI: 10.1007/s00380-013-0408-0
  • Peer Reviewed / Open Access
• [Journal Article] Serum n-3 to n-6 polyunsaturated fatty acids ratio correlates with coronary plaque vulnerability: an optical coherence tomography study (2014)
  • Author(s): Hasegawa T, Otsuka K, Iguchi T, Matsumoto K, Ehara S, Nakata S, Nishimura S, Kataoka T, Shimada K, Yoshiyama M
  • Journal Title: Heart Vessels Volume: 29 Issue: 5 Pages: 596-602
  • DOI: 10.1007/s00380-013-0404-4
  • Peer Reviewed
• [Journal Article] Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1cells (2014)
  • Author(s): Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, Iwao H, Yoshiyama M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 445 Issue: 2 Pages: 327-33
  • DOI: 10.1016/j.bbrc.2014.01.183
  • Peer Reviewed
• [Journal Article] Insulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis (2014)
  • Author(s): Iguchi T, Hasegawa T, Otsuka K, Matsumoto K, Yamazaki T, Nishimura S, Nakata S, Ehara S, Kataoka T, Shimada K, Yoshiyama M
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 15 Issue: 3 Pages: 284-291
  • DOI: 10.1093/ehjci/jet158
  • Peer Reviewed
• [Journal Article] Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in rats. (2013)
  • Author(s): Yamazaki T, Nakamura Y, Shiota M, Osada-Oka M, Fujiki H, Hanatani A, Shimada K, Miura K, Yoshiyama M, Iwao H, Izumi Y.
  • Journal Title: J Pharmacol Sci Volume: 123 Pages: 58-66
• [Journal Article] Napkin-ring sign on coronary CT angiography for the prediction of acute coronary syndrome. (2013)
  • Author(s): Otsuka K, Fukuda S, Tanaka A, Nakanishi K, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M.
  • Journal Title: JACC Cardiovasc Imaging Volume: 6 Issue: 4 Pages: 448-457
  • DOI: 10.1016/j.jcmg.2012.09.016
• [Journal Article] Impact of lesion length on functional significance in intermediate coronary lesions (2013)
  • Author(s): Iguchi T, Hasegawa T, Nishimura S, Nakata S, Kataoka T, Ehara S, Hanatani A, Shimada, K, Yoshiyama M
  • Journal Title: Clin Cardiol Volume: 36 Issue: 3 Pages: 172-177
  • DOI: 10.1002/clc.22076
  • Peer Reviewed
• [Journal Article] Tolvaptan improves left ventricular dysfunction after myocardial infarction in rats. (2012)
  • Author(s): Yamazaki T, Izumi y Nakamura Y, Yamashita N, Fujiki H, Osada-Oka M, Shiota M, Hanatani A, Shimada K, Iwao H, Yoshiyama M.
  • Journal Title: Circ Heart Fail. Volume: 5 Issue: 6 Pages: 794-802
  • DOI: 10.1161/circheartfailure.112.968750
  • Peer Reviewed
• [Journal Article] Peri-atrial epicardial adipose tissue is associated with new-onset nonvalvular atrial fibrillation. (2012)
  • Author(s): Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M.
  • Journal Title: Circ J. Volume: 76 Pages: 2748-54
  • NAID: 10031126044
  • Peer Reviewed
• [Journal Article] Preliminary observations of passive exercise using whole body periodic acceleration on coronary microcirculation and glucose tolerance in patients with type 2 diabetes. (2012)
  • Author(s): Sakaguchi M, Fukuda S, Shimada K, Izumi Y, Izumiya Y, Nakamura Y, Nakanishi K, Otsuka K, Ogawa H, Fujita M, Yoshikawa J, Yoshiyama M.
  • Journal Title: J Cardiol. Volume: 60 Issue: 4 Pages: 283-7
  • DOI: 10.1016/j.jjcc.2012.05.006
  • Peer Reviewed
• [Journal Article] Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart (2012)
  • Author(s): Obana M, Miyamoto K, Murasawa S, Iwakura T, Hayama A, Yamashita T,Shiragaki M, Kumagai S, Miyawaki A, Takewaki K, Matsumiya G, Maeda M, Yoshiyama M, Nakayama H, Fujio Y.
  • Journal Title: Am J Physiol Heart Circ. Physiol Volume: 303(5) Issue: 5 Pages: 569-77
  • DOI: 10.1152/ajpheart.00060.2012
  • Peer Reviewed
• [Journal Article] Impaired coronary flow reserve as a marker of microvascular dysfunction to predict long-term cardiovascular outcomes, acute coronary syndrome and the development of heart failure. (2012)
  • Author(s): Nakanishi K, Fukuda S, Shimada K, Miyazaki C, Otsuka K, Maeda K, Miyahana R, Kawarabayashi T, Watanabe H, Yoshikawa J, Yoshiyama M.
  • Journal Title: Circ J. Volume: 76 Pages: 1958-64
  • NAID: 10030504808
  • Peer Reviewed
• [Journal Article] Prognostic value of aortic valve area index in asymptomatic patients with severe aortic stenosis (2012)
  • Author(s): Toshio Saito, Takashi Muro, Hisateru Takeda, Eiichi Hyodo, Shoichi Ehara, Yasuhiro Nakamura, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama
  • Journal Title: Am J Cardiol Volume: 110 Issue: 1 Pages: 93-97
  • DOI: 10.1016/j.amjcard.2012.02.056
  • Peer Reviewed
• [Journal Article] Comparison of two-dimensional and real-time three-dimensional transesophageal echocardiography in the assessment of aortic valve area. (2012)
  • Author(s): Furukawa A, Abe Y, Tanaka C, Ito K, Tabuchi I, Osawa K, Kino N, Nakagawa E, Komatsu R, Haze K, Yoshiyama M, Yoshikawa J, Naruko T, Itoh A.
  • Journal Title: J Cardiol. Volume: 59 Issue: 3 Pages: 337-43
  • DOI: 10.1016/j.jjcc.2012.01.011
  • NAID: 10031187754
  • Peer Reviewed
• [Journal Article] Novel device that produces carbon dioxide mist for myocardial infarction treatment in rats. (2012)
  • Author(s): Yamazaki T, Izumi Y, Nakamura Y, Hanatani A, Shimada K, Muro T, Shiota M, Iwao H, Yoshiyama M.
  • Journal Title: Circ J. Volume: 76 Pages: 1203-12
  • NAID: 10030132718
  • Peer Reviewed
• [Journal Article] Hyperintense plaque identified by magnetic resonance imaging relates to intracoronary thrombus as detected by optical coherence tomography in patients with angina pectoris (2012)
  • Author(s): Shoichi Ehara, Takao Hasegawa, Shinji Nakata, Kenji Matsumoto, Satoshi Nishimura, Tomokazu Iguchi, Toru Kataoka, Junichi Yoshikawa, Minoru Yoshiyama
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 13 Issue: 5 Pages: 394-399
  • DOI: 10.1093/ehjci/jer305
  • Peer Reviewed
• [Journal Article] Non-obstructive low attenuation coronary plaque predicts three-year acute coronary syndrome events in patients with hypertension: multidetector computed tomographic study. (2012)
  • Author(s): Nakanishi K, Fukuda S, Shimada K, Ehara S, Inanami H, Matsumoto K, Taguchi H, Muro T, Yoshikawa J, Yoshiyama M.
  • Journal Title: J Cardiol. Volume: 59 Issue: 2 Pages: 167-75
  • DOI: 10.1016/j.jjcc.2011.11.010
  • NAID: 10030582245
  • Peer Reviewed
• [Journal Article] Erythrocyte-rich thrombus aspirated from patients with ST-elevaiton myocardial infarction : associationi with oxidative stress and its impact on myocardial reperfusion (2012)
  • Author(s): Yunoki K, Ueda M, et al
  • Journal Title: Eur Heart J Volume: (in press) Issue: 12 Pages: 1480-90
  • DOI: 10.1093/eurheartj/ehr486
  • Peer Reviewed
• [Journal Article] The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice. (2012)
  • Author(s): Yamazaki T, Yamashita N, Izumi Y, Nakamura Y, Shiota M, Hanatani A, Shimada K, Muro T, Iwao H, Yoshiyama M.
  • Journal Title: Hypertens Res. Volume: 35 Issue: 1 Pages: 34-40
  • DOI: 10.1038/hr.2011.139
  • NAID: 10030642721
  • Peer Reviewed
• [Journal Article] Circadian variation in coronary flow velocity reserve and its relation to ﾎｱ1-sympathetic activity in humans. (2012)
  • Author(s): Fukuda S, Shimada K, Maeda K, Kawasaki T, Kono Y, Miyahana R, Jissho S, Taguchi H, Yoshiyama M, Fujita M, Yoshikawa J.
  • Journal Title: Int J Cardiol. Volume: 157 Issue: 2 Pages: 216-20
  • DOI: 10.1016/j.ijcard.2010.12.052
  • Peer Reviewed
• [Presentation] 超小型ミニブタを用いたメタボリック症候群モデル作製 (2014)
  • Author(s): 泉 康雄, 山崎 貴紀, 中村 泰浩, 島田 健永, 葭山 稔, 岩尾 洋
  • Organizer: 日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Visit-to-Visit平均透析中血圧高値は透析患者の大動脈弁狭窄症進行促進因子である (2014)
  • Author(s): 則岡直樹, 岩田 真一, 柳 志郎, 八木 秀也, 吉田 啓子, 蒔田 直記, 白井 たから, 石井 英, 紙森 公雄, 太田 剛弘, 葭山 稔
  • Organizer: 日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] 若年健康女性医療従事者における夜勤が夜間血圧に与える影響 (2014)
  • Author(s): 北田 諒子, 岩田 真一, 花谷 彰久, 杉岡 憲一, 葭山 稔
  • Organizer: 日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Long-term follow up results of balloon angioplasty for focal renal artery stenosis in young female patients with renovascular hypertension. (2014)
  • Author(s): Kazuki Mizutani , Akira Itoh , Kei Yunoki , Ryushi Komatsu , Takahiko Naruko , MinoruYoshiyama.
  • Organizer: ESC Congress
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Vascular functional and morphological alterations in smokers with varenicline therap. (2014)
  • Author(s): Kobayashi M, Takemoto Y, Norioka N, Suto T, Yoshiyama M.
  • Organizer: ESC Congress
  • Place of Presentation: Barcelona(Spain)
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Long-term results of endovascular therapy for below-the-knee lesions in patients with critical limb ischemia in our institution (2014)
  • Author(s): Matsuo Masanori, Nishioka Hiroki, Katayama Hisashi, Kakihara Jun, Koga Yuki, Fujimoto Kouhei, Kasayuki Noriaki, Shimada Kenei, Yoshiyama Minoru.
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 名古屋国際会議場(愛知県・名古屋市)
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] Histlogical findings of Fibromuscular dysplasia in Optical Coherance Tomography (2014)
  • Author(s): Mizutani Kazuki, Itoh Akira, Yunoki Kei, Komatsu Ryushi, Haze Kazuo, Naruko Takahiko, Yoshiyama Minoru.
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 名古屋国際会議場(愛知県・名古屋市)
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] Risk Stratification in Brugada Syndrome by Using the Combination of T-wave-alternans and Heart Rate Variability (2014)
  • Author(s): Sakamoto Shogo, Takagi Masahiko, Tatsumi Hiroaki, Doi Atsushi, Yoshiyama Minoru.
  • Organizer: 日本心電図学会
  • Place of Presentation: ザ・プリンスパークタワー東京(東京都・港区)
  • Year and Date: 2014-07-22 – 2014-07-25
• [Presentation] 虚血性心疾患患者の血中バイオマーカーにおける酸化・抗酸化バランス 血漿中ミエロペルオキシダーゼ(MPO)値と血清パラオキソナーゼ-1(PON-1)値の関連 (2014)
  • Author(s): 柚木 佳, 成子 隆彦, 吉山 智貴, 杉岡 憲一, 仲川 将志, 小松 龍士, 稲葉 真由美, 土師 一夫, 葭山 稔, 上田 真喜子
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都・新宿区)
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 内皮機能検査「FMD」の最新の知見 baIMTとFMD どう使う? 血管機能評価と血管形態評価 (2014)
  • Author(s): 竹本 恭彦, 井口 朋和, 則岡 直樹, 首藤 太一, 葭山 稔
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都・新宿区)
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] athological and Immunohistochcmical Findings at Sites of Restenosis and Late Stent Thrombosis after Drug-Eluting Stents (2014)
  • Author(s): Nakagawa Masashi, Naruko Takahiko, Sugioka Kenichi, Inaba Mayumi, Miyazawa Tsuyoshi, Kamihata Hiroshi, Takanashi Shyuichirou, Yoshiyama Minoru, Ueda Makiko.
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都・新宿区)
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Aortic Arch Calcification on chest X-ray is a simple predictor of Aortic Arch Complex Plaques in patients with Nonvalvular Atrial Fibrillation (2014)
  • Author(s): Ito Asahiro, Sugioka Kenichi, Fujita Suwako, Iwata Shinichi, Matsumura Yoshiki, Naruko Takahiko, Ueda Makiko, Yoshiyama Minoru.
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都・新宿区)
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Relationship between CHADS2 score and complex aortic plaques by transesophageal echocardiography in patients with nonvalvular atrial fibrillation (2014)
  • Author(s): Fujita Suwako, Sugioka Kenichi, Iwata Shinichi, Matsumura Yoshiki, Nakagawa Masashi, Doi Atsushi, Takagi Masahiko, Ueda Makiko, Yoshiyama Minoru.
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都・新宿区)
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Serum Levels of High-density Lipoprotein-Associated Paraoxonase-1 Predict Recurrent Cardiovascular Events after Drug-Eluting Stent Implantation in Patients with Stable Angina Pectoris (2014)
  • Author(s): Yoshiyama Tomotaka, Yunoki Kei, Komatsu Ryushi, Haze Kazuo, Naruko Takahiko, Sugioka Kenichi, Nakagawa Masashi, Yoshiyama Minoru, Inaba Mayumi, Ueda Makiko．
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル(東京都・新宿区)
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 低酸素負荷におけるO-G1cNAc化タンパク質のオートファジーとアポトーシスへの影響 (2014)
  • Author(s): 渡辺 明, 佐々木 泉帆, 古川 裕一, 野村 篤生, 上橋 和佳, 加藤 隆児, 井尻 好雄, 中川 孝俊, 山口 雄大, 泉 康雄, 葭山 稔, 朝日 通雄, 林 哲也
  • Organizer: 日本循環制御医学会総会
  • Place of Presentation: 九州大学医学部 百年講堂(福岡県・福岡市)
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] 間歇的低酸素負荷がBio14.6心筋症ハムスターの心筋組織病変に与える影響 (2014)
  • Author(s): 銭 瑶子, 野村 篤生, 加藤 隆児, 安田 侑紀, 藤原 祐治, 松井 美佳, 室谷 美咲, 川上 淳, 井尻 好雄, 山口 雄大, 泉 康雄, 葭山 稔, 阪本 英二, 田中 一彦, 林 哲也
  • Organizer: 日本循環制御医学会総会
  • Place of Presentation: 九州大学医学部 百年講堂(福岡県・福岡市)
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] フレーバーティにおける血管アンチエイジング効果 (2014)
  • Author(s): 前田 久美子, 島田 健永, 川崎 俊博, 宮花 礼子, 上原 久美子, 豊島 範子, 河野 靖, 久保 知一郎, 田口 晴之, 葭山 稔, 吉川 純一
  • Organizer: 日本抗加齢医学会総会
  • Place of Presentation: 大阪国際会議場(大阪府・大阪市)
  • Year and Date: 2014-06-06 – 2014-06-08
• [Presentation] Tolvaptan Reduces the Dose of Loop Diuretics and Improves Renal function in Patients with Congestive Heart Failure and Renal Dysfunction (2014)
  • Author(s): 花谷彰久、葭山稔 他
  • Organizer: 第78回 日本循環器学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Reduction of Loop Diuretics by Tolvaptan Improves Renal Function in Patients with Congestive Heart Failure and Advanced Renal Dysfunction (2014)
  • Author(s): 花谷彰久、葭山稔 他
  • Organizer: 第78回 日本循環器学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Repeated Remote Ischemic Conditioning Attenuates Left Ventricular Remodeling via Exosome-Mediated Intercellular Communication on Chronic Heart Failure after Myocardial Infarction (2014)
  • Author(s): 山口雄大、葭山稔 他
  • Organizer: 第78回 日本循環器学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 急性心筋梗塞に対するインターロイキン11(IL-11)製剤を用いた心筋保護治療の臨床試験のためのプロトコール作成研究 (2013)
  • Author(s): 大和田 康子, 泉 康雄, 朝倉 正紀, 山本 晴子, 前田 真貴子, 葭山 稔, 藤尾 慈
  • Organizer: 第34回 日本臨床薬理学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 重症大動脈弁狭窄症における日間血圧変動と大動脈弓部プラークとの関連 (2013)
  • Author(s): 岩田 真一, 杉岡 憲一, 松村 嘉起, 藤田 澄吾子, 伊藤 朝広, 穂積 健之, 北田 諒子, 花谷 彰久, 葭山 稔
  • Organizer: 第61回 日本心臓病学会
  • Place of Presentation: ホテル日航熊本
• [Presentation] Dipperは本当にdipperか? 血圧日内変動パターンの変動性に関する検討 (2013)
  • Author(s): 岩田 真一, 泉 康雄, 花谷 彰久, 島田 健永, 葭山 稔
  • Organizer: 第36回 日本高血圧学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Remote ischemic postconditioning improves coronary microcirculation in healthy subjects and in patients with heart failure. (2012)
  • Author(s): Kono Y, Fukuda S, Shimada K, Maeda K, Miyahana R, Kubo T, Jissho S, Taguchi H, Hanatani A, Yoshiyama M.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Preliminary observations of passive exercise using whole body periodic acceleration on coronary microcirculation and glucose tolerance in patients with type 2 diabetes. (2012)
  • Author(s): Sakaguchi M, Fukuda S, Shimada K, Izumi Y, Izumiya Y, Nakamura Y, Nakanishi K, Otsuka K, Ogawa H, Fujita M, Yoshikawa J, Yoshiyama M.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Persistent impairment of arterial stiffness is associated with future cardiovascular outcome in patients with coronary artery disease. (2012)
  • Author(s): Otsuka K, Fukuda S, Shimada K, Nakanishi K, Yoshikawa J, Yoshiyama M.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Ring-like sign on coronary computed tomographic angiography is associated with near-future acute coronary syndrome in patients with coronary artery disease. (2012)
  • Author(s): Otsuka K, Fukuda S, Tanaka A, Nakanishi K, Sakamoto M, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Diagnostic accuracy and cost-effectiveness of pocket-sized transthoracic echocardiography. (2012)
  • Author(s): Kitada R, Fukuda S, Watanabe H, Oe H, Abe Y, Shimada K, Yoshiyama M, Ito H, Yoshikawa J.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Low attenuation coronary plaque on multidetector computed tomography predicts three-year acute coronary syndrome events in patients with hypertension. (2012)
  • Author(s): Nakanishi K, Fukuda S, Shimada K, Ehara S, Inanami H, Matsumoto K, Taguchi H, Muro T, Yoshikawa J, Yoshiyama M.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Peri-atrial epicardial adipose tissue is associated with new-onset non-valvular atrial fibrillation. (2012)
  • Author(s): Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Insulin resistance is associated with coronary plaque vulnerability: an Optical Coherence Tomography study. (2012)
  • Author(s): Tomokazu Iguchi, Takao Hasegawa, Kenichiro Otsuka, Satoshi Nishimura, Toru Kataoka, Shoichi Ehara, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama.
  • Organizer: European society of cardiology congress 2012, Aug 25-29, 2012, Munich, Germany.
  • Place of Presentation: Munich, Germany.
• [Presentation] Impact of increased epicardial adipose tissue volume on future acute coronary syndrome in patients with coronary artery disease. (2012)
  • Author(s): Nakanishi K, Fukuda S, Tanaka A, Otsuka K, Sakamoto M, Taguchi H, Yoshikawa J, Shimada K, Yoshiyama M.
  • Organizer: American heart association scientific sessions 2012, Nov 3-7, 2012, Los Angeles, USA.
  • Place of Presentation: Los Angeles, USA.
• [Presentation] Persistent impairment of arterial stiffness is associated with future cardiovascular events in patients with hypertension; cardio-ankle vascular index study. (2012)
  • Author(s): Otsuka K, Fukuda S, Shimada K, Nakanishi K, Taguchi H, Yoshikawa J, Yoshiyama M.
  • Organizer: American heart association scientific sessions 2012, Nov 3-7, 2012, Los Angeles, USA.
  • Place of Presentation: Los Angeles, USA.
• [Presentation] Percutaneous carbon dioxide treatment using a gas mist generator accelerates angiogenesis in the ischemic hindlimb. (2012)
  • Author(s): Yasukatsu Izumi, Takanori Yamazaki, Yasuhiro Nakamura, Takehiro Yamaguchi, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama, Hiroshi Iwao.
  • Organizer: American heart association scientific sessions 2012, Nov 3-7, 2012, Los Angeles, USA.
  • Place of Presentation: Los Angeles, USA.
• [Presentation] Percutaneous carbon dioxide mist treatment improves cardiac function after myocardial infarction in rats via nitric oxide activity. (2012)
  • Author(s): Takanori Yamazaki, Yasuhiro Nakamura, Yasukatsu Izumi, Takehiro Yamaguchi, Akihisa Hanatani, Kenei Shimada, Hiroshi Iwao, Minoru Yoshiyama.
  • Organizer: American heart association scientific sessions 2012, Nov 3-7, 2012, Los Angeles, USA.
  • Place of Presentation: Los Angeles, USA.
• [Presentation] Vasopressin V2 receptor antagonist tolvaptan prevents the development of chronic heart failure via its anti-inflammatory and anti-fibrotic actions. (2012)
  • Author(s): Takanori Yamazaki, Yasuhiro Nakamura, Yasukatsu Izumi, Takehiro Yamaguchi, Akihisa Hanatani, Kenei Shimada, Hiroshi Iwao, Minoru Yoshiyama.
  • Organizer: American heart association scientific sessions 2012, Nov 3-7, 2012, Los Angeles, USA.
  • Place of Presentation: Los Angeles, USA.
• [Presentation] II度以上の未治療高血圧症例に対する高用量ARB投与の有用性 ARB/CCB併用投与との比較検討 (2012)
  • Author(s): 中村 泰浩, 泉 康雄, 葭山 稔
  • Organizer: 日本高血圧学会臨床高血圧フォーラム
  • Place of Presentation: 大阪府豊中市
• [Presentation] 健常人の血管内皮機能に対する遠隔虚血コンディショニングの効果の検討 (2012)
  • Author(s): 井口 朋和, 竹本 恭彦, 島田 健永, 大塚 憲一郎, 中西 弘毅, 松本 健嗣, 兵頭 永一, 花谷 彰久, 室生 卓, 葭山 稔
  • Organizer: 日本高血圧学会臨床高血圧フォーラム
  • Place of Presentation: 大阪府豊中市
• [Presentation] 血管中内膜複合体厚と内皮依存性血管拡張反応の関連性 上腕動脈における同時測定による検討 (2012)
  • Author(s): 井口 朋和, 竹本 恭彦, 島田 健永, 花谷 彰久, 室生 卓, 葭山 稔
  • Organizer: 日本高血圧学会臨床高血圧フォーラム
  • Place of Presentation: 大阪府豊中市
• [Presentation] 弁膜症の診断と治療 重症大動脈弁狭窄症における経食道心エコーによる大動脈弓部プラークの評価について (2012)
  • Author(s): 杉岡 憲一, 穂積 健之, 松村 嘉起, 伊藤 朝広, 葭山 稔
  • Organizer: 日本超音波医学会学術集会
  • Place of Presentation: 東京都港区
• [Presentation] 植込み型除細動器(ICD)によるshock直後の心室再分極の不均一性に対するNifekalantとAmiodaroneの効果 (2012)
  • Author(s): 前田 惠子, 高木 雅彦, 鈴木 健太郎, 辰巳 裕亮, 葭山 稔
  • Organizer: 日本不整脈学会学術大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Brugada症候群におけるT-wave Alternansの日内変動についての検討 (2012)
  • Author(s): 鈴木 健太郎, 高木 雅彦, 前田 惠子, 辰己 裕亮, 葭山 稔
  • Organizer: 日本不整脈学会学術大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] 健常人の血管内皮機能に対する遠隔虚血コンディショニングの効果の検討 (2012)
  • Author(s): 井口 朋和, 竹本 恭彦, 島田 健永, 松本 健嗣, 大塚 憲一郎, 中西 弘毅, 兵頭 永一, 花谷 彰久, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 心サルコイドーシスにおける心臓MRIガドリニウム遅延造影の特徴 (2012)
  • Author(s): 松本 健嗣, 江原 省一, 長谷川 隆生, 中田 真司, 大塚 憲一郎, 井口 朋和, 高木 雅彦, 花谷 彰久, 穂積 健之, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 大動脈二尖弁の診断における経胸壁および経食道心エコーの相違 大動脈弁置換症例での検討 (2012)
  • Author(s): 武田 久輝, 室生 卓, 齋藤 聡男, 兵頭 永一, 江原 省一, 花谷 彰久, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 光干渉断層像による冠動脈インターベンション後のFilter no-reflowの予測因子に関する検討 (2012)
  • Author(s): 井口 朋和, 長谷川 隆生, 松本 健嗣, 大塚 憲一郎, 中田 真司, 江原 省一, 花谷 彰久, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 大動脈弁狭窄症の重症度指標を再考する (2012)
  • Author(s): 齋藤 聡男, 室生 卓, 武田 久輝, 兵頭 永一, 花谷 彰久, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 薬物加療が著効した右室二腔症の一例 (2012)
  • Author(s): 山下 智子, 松村 嘉起, 杉岡 憲一, 江原 省一, 花谷 彰久, 穂積 健之, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 大動脈弁狭窄症における近位胸部大動脈の形態的変化についての検討 三尖弁と二尖弁大動脈弁狭窄症の比較 (2012)
  • Author(s): 藤田 澄吾子, 杉岡 憲一, 伊藤 朝広, 岩田 真一, 松村 嘉起, 穂積 健之, 末廣 茂文, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 大動脈弁狭窄症における冠動脈疾患合併と大動脈弓部プラークとの関連 経食道心エコー図による検討 (2012)
  • Author(s): 伊藤 朝広, 杉岡 憲一, 藤田 澄吾子, 岩田 真一, 松村 嘉起, 穂積 健之, 末廣 茂文, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 慢性腎臓病と大動脈プラークとの関連 近位胸部大動脈と遠位胸部大動脈との比較検討 (2012)
  • Author(s): 松村 嘉起, 杉岡 憲一, 藤田 澄吾子, 伊藤 朝広, 岩田 真一, 穂積 健之, 末廣 茂文, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 大動脈弁狭窄症を弁尖数から検討する 二尖弁と三尖弁の比較 (2012)
  • Author(s): 齋藤 聡男, 室生 卓, 武田 久輝, 兵頭 永一, 花谷 彰久, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] たこつぼ型心筋症の重症化例を急性期心電図の特徴・心エコーの心機能指標で予測は可能か (2012)
  • Author(s): 則岡 直樹, 太田 剛弘, 谷川 崇, 河合 慶介, 西山 裕善, 石川 世良, 白井 たから, 紙森 公雄, 柳 志郎, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 当院におけるトルバプタン使用例の検討 (2012)
  • Author(s): 白井 伸幸, 藤田 澄吾子, 長倉 俊樹, 村田 恵理子, 田中 秀昌, 河瀬 吉雄, 西本 正紀, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市
• [Presentation] 循環器疾患とMRI Whole Heart Coronary T1-weighted Black Blood MRIを用いた冠動脈不安定プラーク描出の試み (2012)
  • Author(s): 江原 省一, 長谷川 隆生, 中田 真司, 松本 健嗣, 井口 朋和, 大塚 憲一郎, 島田 健永, 葭山 稔
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 石川県金沢市