Association between intraplaque macrophage level and plaque rupture

• Project/Area Number: 24591068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Tanaka Atsushi 和歌山県立医科大学, 医学部, 准教授 (50458072)
• Co-Investigator(Kenkyū-buntansha): NISHIGUCHI TSUYOSHI 和歌山県立医科大学, 医学部, 学内助教 (40549771)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ST上昇型心筋梗塞 / 非ST上昇型心筋梗塞 / 光干渉断層法 / マトリックスメタロプロテイナーゼ９ / ミエロペルオキシダーゼ / ST上昇型急性心筋梗塞 / 非ST上昇型急性心筋梗塞 / マトリックスメタロプロテイナーゼ9 / 国際情報交換

Outline of Final Research Achievements

Clinical manifestation of ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) has clinical implications for patient management.
Plasma matrix metalloproteinase 9 level in coronary circulation was significantly elevated in patients with STEMI than those with NSTEMI, while plasma myeloperoxidase level was similar between groups. The prevalance of plaque rupture by optical coherence tomography was similar between groups. Coronary MMP-9 level was the independent determinant of STEMI.

Research Products

• [Journal Article] European Society of Cardiology (ESC) Congress Report From London 2015 (2015)
  • Author(s): Tsuyoshi Nishiguchi, Takashi Akasaka
  • Journal Title: Circulation Journal Volume: 79 Issue: 11 Pages: 2306-2313
  • DOI: 10.1253/circj.CJ-15-1049
  • NAID: 130005104906
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Vasa vasorum restructuring in human atherosclerotic plaque vulnerability; A clinical optical coherence tomography study (2015)
  • Author(s): Akira Taruya, Atsushi Tanaka, Tsuyoshi Nishiguchi et al.
  • Journal Title: JACC Volume: 未定
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prevalence of Spontaneous Coronary Artery Dissection in Patients with Acute Coronary Syndrome (2014)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Yuichi Ozaki, et al
  • Journal Title: European Heart Journal Acute Cardiovascular Care Volume: before print Issue: 3 Pages: 263-270
  • DOI: 10.1177/2048872613504310
  • Peer Reviewed
• [Journal Article] Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography (2014)
  • Author(s): Manabu Kashiwagi, Linbo Liu, KK Chu, CH Sun, Atsushi Tanaka et al.
  • Journal Title: Plos One Volume: 9 Issue: 7 Pages: e102669-e102669
  • DOI: 10.1371/journal.pone.0102669
  • Peer Reviewed / Open Access
• [Journal Article] Persistent epicardial adipose tissue accumulation is associated with coronary plaque vulnerability and future acute coronary syndrome in non-obese subjects with coronary artery disease (2014)
  • Author(s): Koki Nakanishi, Shota Fukuda, Atsushi Tanaka et al.
  • Journal Title: Atherosclerosis Volume: 237 Issue: 1 Pages: 353-360
  • DOI: 10.1016/j.atherosclerosis.2014.09.015
  • Peer Reviewed
• [Presentation] Association of Local Matrix Metalloproteinase 9 Levels with Clinical Manifestation in Patients with Acute Myocardial Infarction (2016)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Akira Taruya et al.
  • Organizer: 2016 European Society of Cardiology
  • Place of Presentation: ローマ、イタリア
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Local matrix metalloproteinase 9 levels are associated with clinical manifestation in patients with myocardial infarction. (2016)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Akira Taruya et al.
  • Organizer: 2016 日本循環器学会
  • Place of Presentation: 仙台、日本
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Clinical characteristics and angiographic features of optical coherence tomography verified spontaneous coronary artery dissection in patients with acute coronary syndrome. (2016)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Akira Taruya et al.
  • Organizer: 2016 日本循環器学会
  • Place of Presentation: 仙台、日本
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Clinical characteristics and angiographic features of optical coherence tomography verified spontaneous coronary artery dissection in patients with acute coronary syndrome (2015)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka et al.
  • Organizer: ヨーロッパ心臓病学会 2015
  • Place of Presentation: イギリス ロンドン
  • Year and Date: 2015-08-29 – 2015-09-02
• [Presentation] Patient characteristics and prognosis of OCT verified calcified nodules in patients with acute coronary syndrome (2015)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka et al.
  • Organizer: ヨーロッパ心臓病学会 2015
  • Place of Presentation: イギリス ロンドン
  • Year and Date: 2015-08-29 – 2015-09-02
• [Presentation] Association of Local Matrix Metalloproteinase 9 Levels with Clinical Manifestation in Patients with Acute Myocardial Infarction (2015)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Akira Taruya et al.
  • Organizer: 2015 European Society of Cardiology
  • Place of Presentation: ロンドン、イギリス
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] 急性冠症候群における特発性冠動脈解離の頻度についての検討 (2015)
  • Author(s): 西口毅、田中篤、樽谷玲 他
  • Organizer: 2015年 日本内科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-10 – 2015-04-12
• [Presentation] Local matrix metalloproteinase 9 levels are associated with clinical manifestation in patients with myocardial infarction. (2014)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Yuichi Ozaki et al.
  • Organizer: ESC congress 2014
  • Place of Presentation: スペイン バルセロナ
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] 侵襲的冠動脈イメージング法で冠動脈病理に迫る (2014)
  • Author(s): 田中篤
  • Organizer: CVIT2014 シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2014-07-26
• [Presentation] 2014 (2014)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, et al
  • Organizer: ESC congress 2014
  • Place of Presentation: Barcelona
• [Presentation] Prognosis of spontaneous coronary artery dissection (2013)
  • Author(s): Tsuyoshi Nishiguchi, Atsushi Tanaka, Yuichi Ozaki et al.
  • Organizer: ESC congress 2013
  • Place of Presentation: オランダ アムステルダム
• [Presentation] Spontaneous coronary artery dissection の予後についての検討 (2013)
  • Author(s): 西口毅、田中篤、尾崎雄一 他
  • Organizer: 第27回日本冠疾患学会学術集会
  • Place of Presentation: 和歌山
• [Presentation] OCTからみたACSの発症機序
  • Author(s): 田中篤
  • Organizer: 第23回IVUS研究会
  • Place of Presentation: 名古屋
• [Presentation] Improving clinical outcome with new OCT technology
  • Author(s): 田中篤
  • Organizer: CVIT 2013 シンポジウム
  • Place of Presentation: 神戸
• [Presentation] In vivo pathology with OCT
  • Author(s): 田中篤
  • Organizer: 日本血管内視鏡学会
  • Place of Presentation: 久留米