• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of LR11,proliferation marker of Vascular smooth muscle cell for Pulmonary hypertension

Research Project

Project/Area Number 24591069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionJuntendo University

Principal Investigator

KONISHI HAKUOH  順天堂大学, 医学部, 准教授 (50459145)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肺高血圧症 / 血管平滑筋細胞 / LR11 / バイオマーカー / 肺高血圧
Outline of Final Research Achievements

Pulmonary arterial hypertension (PAH) is pathophysiologically characterized with medial thickening of smooth muscle cells (SMCs). LR11 is expressed in intimal smooth muscle cells. This study examined the role of LR11 in pulmonary hypertension.The expression LR11, together with HIF-1α was significantly increased under hypoxic conditions compared with normoxia in mouse lung. Serum sLR11 levels were increased under hypoxic condition. The increased right ventricular systolic pressure, right ventricular hypertrophy and medial thickening in wild-type mice were attenuated in KO mice. The expression of LR11 and HIF-1α was increased in cultured SMCs under hypoxic conditions and the knockdown of HIF-1α abolished the hypoxia-induced LR11 induction. Human study showed that serum sLR11 levels were significantly higher in patients with PAH.The sLR11 levels were positively correlated with pulmonary vascular resistance and mean pulmonary arterial pressure.Soluble LR11 may be a novel biomarker.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013

All Presentation (6 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Presentation] LR11 Gene Deficiency Prevents Hypoxia-induced Pulmonary Arterial Hypertension2015

    • Author(s)
      Le Jiang,Hakuoh Konishi, Meizi Jiang,Hideaki Bujo, Hiroyuki Daida
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] LR11 Gene Deletion Prevents Pulmonary Hypertension and Vascular Remodeling under Hypoxia Condition2014

    • Author(s)
      Le Jiang; Hakuoh Konishi; Hiroyuki Daida
    • Organizer
      European Society of Cardiology 2015
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] LR11 Is A Novel Biomarker Of Pulmonary Arterial Hypertension2014

    • Author(s)
      Hakuoh Konishi, Jiang Le, Hiroyuki Daida
    • Organizer
      AMERICAN THORACIC SOCIETY
    • Place of Presentation
      San Diego
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] LR11 Gene Deletion Prevents Pulmonary Hypertension and Vascular Remodeling under Hypoxia Condition2014

    • Author(s)
      Le Jiang, Hakuoh Konishi、 Meizi Jiang, Hideaki Bujo, Hiroyuki Daida
    • Organizer
      日本循環器学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] LR11 is a novel biomarker of pulmonary arterial hypertension2014

    • Author(s)
      Hakuoh Konishi、 Le Jiang, Hiroyuki
    • Organizer
      American thoracic society (ATS)
    • Place of Presentation
      San Diego USA
    • Related Report
      2013 Research-status Report
  • [Presentation] LR11 Gene Deletion Prevents Pulmonary Hypertension and Vascular Remodeling under Hypoxia Condition2014

    • Author(s)
      Le Jiang, Hakuoh Konishi、 Hiroyuki Daida
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      バルセロナ
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 新規な肺高血圧のマーカー2013

    • Inventor(s)
      小西博応、代田浩之、海老沼宏幸、藤村建午
    • Industrial Property Rights Holder
      小西博応、代田浩之、海老沼宏幸、藤村建午
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013
    • Related Report
      2012 Research-status Report
    • Overseas

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi