Impact of exercise therapy on stabilization of coronary plaque after acute coronary syndrome.
| Project/Area Number |
24591071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAUCHI Katsumi 順天堂大学, 医学部, 先任准教授 (60200119)
KAZUNORI Shimada 順天堂大学, 医学部, 先任准教授 (60327814)
YOKOYAMA Miho 順天堂大学, 医学部, 助教 (60407301)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 急性冠症候群 / 血管内超音波 / 冠動脈プラーク / 包括的心臓リハビリテーション / 身体活動量 / プラークの安定化 |
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| Outline of Final Research Achievements |
We enrolled 40 patients with ACS who had been treated by emergency percutaneous coronary intervention for culprit lesions and having an untouched non-culprit target lesion of <25% stenosis that could be visualized by IB-IVUS. The average age was 60±11 years old, and thirty-seven were male. Twenty-eight patients had ST elevated MI. The culprit lesions included 22 left anterior descending arteries, 5 left circumflex arteries, and 13 right coronary arteries. With regard to coronary risk factors, 23 patients had hypertension, 39 patients had dyslipidemia, 11 patients had diabetes, and 17 patients had smoking.
Patients were assigned into the aggressive CR group (n=20) and the usually CR groups (n=20). No significant differences of age, gender, coronary risk factors, number of diseased vessels, or ejection fraction, were observed between the two groups. Until now, restudy of IB-IVUS had completed in 32 out of 40 subjects. We expect that the final analysis will be completed in early August.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Impact of lipoprotein(a) as residual risk on long-term outcomes in patients after percutaneous coronary intervention.2015
Author(s)
Konishi H, Miyauchi K, Kasai T, Tsuboi S, Ogita M, Naito R, Sai E, Fukushima Y, Katoh Y, Okai I, Tamura H, Okazaki S, Daida H.
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Journal Title
Am J Cardiol.
Volume: 115
Pages: 157-160
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term prognosis and clinical characteristics of young adults (≤40 years old) who underwent percutaneous coronary intervention.2014
Author(s)
Konishi H, Miyauchi K, Kasai T, Tsuboi S, Ogita M, Naito R, Katoh Y, Okai I, Tamura H, Okazaki S, Daida H.
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Journal Title
J Cardiol.
Volume: 64
Pages: 171-4
Related Report
Peer Reviewed / Open Access
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[Journal Article] Low high-density lipoprotein cholesterol is a residual risk factor associated with long-term clinical outcomes in diabetic patients with stable coronary artery disease who achieve optimal control of low-density lipoprotein cholesterol.2014
Author(s)
Ogita M, Miyauchi K, Miyazaki T, Naito R, Konishi H, Tsuboi S, Dohi T, Kasai T, Yokoyama T, Okazaki S, Kurata T, Daida H.
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Journal Title
Heart Vessels.
Volume: 29
Pages: 35-41
Related Report
Peer Reviewed
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[Journal Article] Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome.2013
Author(s)
Dohi T, Miyauchi K, Ohkawa R, Nakamura K, Kurano M, Kishimoto T, Yanagisawa N, Ogita M, Miyazaki T, Nishino A, Yaginuma K, Tamura H, Kojima T, Yokoyama K, Kurata T, Shimada K, Daida H, Yatomi Y.
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Journal Title
Atherosclerosis.
Volume: 229
Pages: 192-7
Related Report
Peer Reviewed
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