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The role of PSGL-1-expressing CD4 T cells in the culprit lesion of acute coronary syndrome

Research Project

Project/Area Number 24591073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

SATO Kayoko  東京女子医科大学, 医学部, 講師 (20246482)

Co-Investigator(Kenkyū-buntansha) SUZUKI Atsushi  東京女子医科大学, 医学部, 助教 (00625626)
SAWABE Motoji  東京医科歯科大学, その他の研究科, 教授 (30196331)
Co-Investigator(Renkei-kenkyūsha) HAGIWARA Nobuhisa  東京女子医科大学, 医学部, 教授 (00180802)
Research Collaborator KITAMURA Kazutaka  
SAITO Takashi  
ENDO Keiko  
FUTASE Atsuko  
MASUDA Chieko  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsPSGL-1 / 動脈硬化 / 急性冠症候群 / 炎症 / 免疫 / 接着分子 / T細胞 / 白血球 / 不安定粥腫 / T細胞 / アポトーシス / PSGL-1 / Selectin
Outline of Final Research Achievements

Adhesion of circulating leukocytes to the endothelial cells (ECs) and subsequent trans-endothelial migration are important in the development of atherosclerosis. This process is predominantly mediated by adhesion molecules, which are expressed on ECs and leukocytes. The culprit coronary artery and atherosclerotic plaque from patients with acute coronary syndrome (ACS) underwent the thrombus-aspiration therapy contained abundant PSGL-1+CD4+T cells. These PSGL-1+CD4+T cells strongly bound to both P-selectin and E-selectin, and induced EC apoptosis.
Furthermore, in apolipoprotein E (ApoE) deficient mice, the advanced atherosclerosis with many activated IFNγ+CD4 T cells, IL17+CD4 T cells, and apoptosis were observed. In contrast, these features were inhibited in PSGL-1/ApoE double deficient mice, contributing more stabilized morphologic features. We concluded that PSGL-1 expressing CD4+T cells participate directly in the development of atherosclerosis and plaque instability in ACS.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2015 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Invited: 2 results)

  • [Journal Article] Sudden cardiac arrest secondary to cardiac amyloidosis in a young woman with cryopyrin-associated periodic syndrome2015

    • Author(s)
      Keiko Endo, Atsushi Suzuki, Kayoko Sato, Tsuyoshi Shiga
    • Journal Title

      BMJ Case Reports

      Volume: - Pages: 1-5

    • DOI

      10.1136/bcr-2015-209468

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 女性の動脈硬化症の特徴:Atherosclerosis in women. 女性の循環器疾患を考える2015

    • Author(s)
      佐藤加代子
    • Journal Title

      Heart View

      Volume: 19 Pages: 20-25

    • Related Report
      2014 Annual Research Report
  • [Journal Article] PSGL-1陽性CD4 T細胞の動脈硬化進展における役割2015

    • Author(s)
      佐藤加代子, 喜多村一孝, 鈴木敦, 萩原 誠久
    • Journal Title

      013 Annual Report of the Japan Research Promotion Society for Cardiovascular Disease

      Volume: 28 Pages: 11-15

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Helper T Cell Diversity and Plasticity2014

    • Author(s)
      Kayoko Sato
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 12 Pages: 2843-2844

    • DOI

      10.1253/circj.CJ-14-1164

    • NAID

      130004704008

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of the serum bone-specific alkaline phosphatase level at the initiation of hemodialysis therapy for end-stage renal disease on cardiovascular events2014

    • Author(s)
      Fukushima N, Suzuki A, Fukushima K, Tanaka Y, Sato Y, Shiga T, Nitta K, Hagiwara N.
    • Journal Title

      IJC Metabolic & Endocrine

      Volume: 4 Pages: 58-62

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice.2013

    • Author(s)
      Kishimoto, Y., Kanai, T., Sato, K., Lee, J., Jeong, K.S., Shimokado, K., Maruyama, N., Ishigami, A.
    • Journal Title

      Pediatr. Res.

      Volume: 73 Issue: 5 Pages: 578-584

    • DOI

      10.1038/pr.2013.22

    • NAID

      110009674991

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] PSGL-1陽性CD4 T細胞が急性冠症候群の責任冠動脈で果たす役割2013

    • Author(s)
      佐藤加代子, 喜多村一孝, 福島 敬子, 萩原 誠久
    • Journal Title

      日本心臓血圧研究振興会(平成二十四年度研究業績集)

      Volume: 27 Pages: 21-26

    • Related Report
      2013 Research-status Report
  • [Journal Article] Reversible cardiomyopathy after radiofrequency ablation ablation of 30-year persistent atrial tachycardia2013

    • Author(s)
      Suzuki Atsushi, Shiga Tsuyoshi, Arai Kotaro, Shoda Morio, Suzuki Atsushi, Hagiwara Nobuhisa
    • Journal Title

      BMJ Case Rep

      Volume: 2013 Dec 10 Pages: bcr2013008727-bcr2013008727

    • DOI

      10.1136/bcr-2013-008727

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contributing factors to the apparent clearance of bepridil in patients with paroxysmal or persistent atrial fibrillation: analysis using population pharmacokinetics2013

    • Author(s)
      Shiga Tsuyoshi, Hashiguchi Masayuki, Naganuma Miyoko
    • Journal Title

      Ther Drug Monit

      Volume: 35 Pages: 367-373

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lack of pharmacokinetic interaction between pilsicanide and rifampicin in healthy volunteers2013

    • Author(s)
      Shiga T, Hashiguchi M, Nakamura K, Shimizu M, Shimizu K, Suzuki A, Mochizuki M, Hagiwara N.
    • Journal Title

      Japanese Journal of Clnical Pharmacology and Therapeutics

      Volume: 44 Pages: 301-305

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] PSGL-1-expressing CD4 T cells induce endothelial cell apoptosis in perimenopausal women2012

    • Author(s)
      Gomita K, Sato K, Yoshida M, Hagiwara N
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 19 Pages: 227-236

    • NAID

      130004444592

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Amiodarone Treatments Improve the Effector Function of Memory T Cells in Heart Failure2014

    • Author(s)
      Sato Kayoko, Kitamura Kazutaka, Suzuki Atsushi, Futase Atsuko, Masuda Chieko, Shiga Tsuyoshi, Hagiwara Nobuhisa
    • Organizer
      43th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Kyoto International Conference Center (Kyoto Prefecture・Kyoto)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] IL17 contribute to the atherosclerotic development and the initiation of chronic kidney disease (CKD)2014

    • Author(s)
      Yusuke Tanigaito, Kayoko Sato, Kitamura Kazutaka, Atsuko Futase, Keiko Fukushima, Kenta Uto, Nobuhisa Hagiwara
    • Organizer
      2014 Scientific Session of American Heart Association
    • Place of Presentation
      McCormick Place(Chicago, USA)
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Amiodarone Treatments Improve the Inflammation in Heart Failure2014

    • Author(s)
      Yusuke Tanigaito, Kayoko Sato, Kitamura Kazutaka, Atsushi Suzuki, Atsuko Futase, Tsuyoshi Shiga, Nobuhisa Hagiwara
    • Organizer
      2014 Scientific Session of American Heart Association
    • Place of Presentation
      McCormick Place(Chicago, USA)
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Atorvastatin improved the atherosclerotic renal dysfunction by the inhibition of inflammation in kidney2014

    • Author(s)
      Kitamura Kazutaka, Kayoko Sato, Keiko Endo, Atsuko Futase, Chieko Masuda, Kenta Uto, Nobuhisa Hagiwara
    • Organizer
      第46回日本動脈硬化学会総会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] DPP-4阻害薬による動脈硬化進展と炎症抑制2014

    • Author(s)
      二瀬敦子、佐藤加代子、喜多村一孝、増田知恵子、萩原誠久
    • Organizer
      第46回日本動脈硬化学会総会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of T cell in the atherosclerotic plaque development2014

    • Author(s)
      Kayoko Sato
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IL17 contribute to the atherosclerotic development and the initiation of chronic kidney disease (CKD) in ApoE deficient mouse2014

    • Author(s)
      Keiko Endo, Kayoko Sato, Kitamura Kazutaka, Keiko Fukushima, Kenta Uto, Nobuhisa Hagiwara
    • Organizer
      The 18th Interbational Vascular Biology Meeting
    • Place of Presentation
      京都市勧業館みやこめっせ(京都府・京都市)
    • Year and Date
      2014-04-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Statin improved the atherosclerotic renal dysfunction2014

    • Author(s)
      Kitamura Kazutaka, Kayoko Sato, Keiko Endo, Atsuko Futase, Chieko Masuda, Kenta Uto, Nobuhisa Hagiwara
    • Organizer
      The 18th Interbational Vascular Biology Meeting
    • Place of Presentation
      京都市勧業館みやこめっせ(京都府・京都市)
    • Year and Date
      2014-04-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of PSGL-1 Expressing CD4 T Cells in Acute Coronary Syndrome.

    • Author(s)
      KITAMURA Kazutaka, SATO Kayoko, GOMITA Keiko, HAGUWARA Nobuhisa
    • Organizer
      European Atherosclerosis Society Congress
    • Place of Presentation
      Lyon, France
    • Related Report
      2013 Research-status Report
  • [Presentation] 動脈硬化進展における接着分子PSGL-1の役割

    • Author(s)
      喜多村一孝、佐藤加代子、遠藤景己、鈴木敦、萩原誠久
    • Organizer
      第45回日本動脈硬化学会総会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Amiodarone Treatments Improve the Inflammation in Heart Failure Patients with Nonischemic Cardiomyopathy

    • Author(s)
      Kitamura Kazutaka, Sato Kayoko, Suzuki Atsushi, Makita Fumiko,Futase Atsuko, Masuda Chieko, Tsuyoshi Shiga, Nobuhisa Hagiwara
    • Organizer
      42th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Research-status Report
  • [Presentation] 動脈硬化進展と粥腫不安定化における接着分子とCD4+T細胞サブセットの役割

    • Author(s)
      佐藤加代子
    • Organizer
      第43回日本心脈管作動物質学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Amiodarone Treatments Improve the Inflammation in Heart Failure

    • Author(s)
      Kitamura Kazutaka, Kayoko Sato, Suzuki Atsushi, Futase Atsuko, Masuda Chieko, Tsuyoshi Shiga, Nobuhisa Hagiwara
    • Organizer
      第78回日本循環器学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] The Role of PSGL-1 on Leucocytes in Acute Coronary Syndrome and the Development of Atherosclerosis

    • Author(s)
      Kazutaka Kitamura, Kayoko Sato, Fukushima Keiko, Futase Atsuko, Masuda Chieko, Nobuhisa Hagiwara
    • Organizer
      第78回日本循環器学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Th1 and Th17 T cells Contribute to the Microalbuminuria in ApoE Deficient Mice

    • Author(s)
      鈴木敦, 佐藤加代子, 五味田敬子, 齋藤貴志, 内田啓子, 新田孝作, 萩原誠久
    • Organizer
      第49回日本臨床分子医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] エストロゲン低下に伴うCD4 T細胞上の接着分子PSGL-1発現亢進と血管内皮細胞障害

    • Author(s)
      佐藤加代子, 萩原誠久
    • Organizer
      第16回日本適応学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] CD4 T-Cells Contribute to the Microalbuminuria with the Dysfunction of Podocytes.

    • Author(s)
      Atsushi Suzuki, Kayoko Sato, Takashi Saito, Keiko Gomita, Keiko Uchida, Nobuhisa Hagiwara
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Amiodarone Treatments improve the IL-6 Levels in Heart Failure Patients with Nonischemic Cardiomyopathy

    • Author(s)
      Atsushi Suzuki, Kayoko Sato, Saito Takashi, Tsuyoshi Shiga, Nobuhisa Hagiwara
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] PSGL-1+CD4+ T Cells induced Endothelial Cell Apoptosis in Perimenopausal Women with Low Estrogen

    • Author(s)
      Kayoko Sato
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] PSGL-1+CD4+ T Cells Contribute Atherosclerotic Plaque Instability

    • Author(s)
      Kitamura Kazutaka, Sato Kayoko, Gomita Keiko, Suzuki Atsushi, Hagiwara Nobuhisa
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] IL17 and INF contribute to the atherosclerotic development and microalbuminuria with the dysfunction of podocytes

    • Author(s)
      Keiko Endo, Kayoko Sato, Suzuki Atsushi, Keiko Fukushima, Kitamura Kazutaka, Hagiwara Nobuhisa
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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