Impact of residual platelet function on late stent thrombosis after drug-eluting stent implantation

• Project/Area Number: 24591079
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: OKURA Hiroyuki 川崎医科大学, 医学部, 准教授 (30425136)
• Co-Investigator(Kenkyū-buntansha): YOJI Neishi 川崎医科大学, 医学部, 講師 (80319946) ; KIYOSHI Yoshida 川崎医科大学, 医学部, 教授 (60322583)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ステント血栓症 / 光干渉断層法 / 冠動脈 / 血小板凝集 / クロピドグレル耐性 / 虚血性心疾患

Outline of Final Research Achievements

To clarify relationship between clopidogrel resistance and intra-stent thrombus formation following drug-eluting stent implantation, 152 stented lesions from 74 patients were enrolled and studied. At follow-up (mean 10 months) after stenting, intra-stent thrombus detected by optical coherence tomography was more frequently found in patients with clopidogrel resistance. In conclusion, clopidogrel resistance may be related to intra-stent thrombus formation after drug-eluting stent implantation.

Research Products

• [Journal Article] Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography (2014)
  • Author(s): Okura H,
  • Journal Title: Circulation Journal Volume: 78 Issue: 11 Pages: 2622-2623
  • DOI: 10.1253/circj.CJ-14-1045
  • NAID: 130004693859
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Presentation] Clopidogrel resistance and intra-stent thrombi assessed by optical coherence after drug-eluting stent implantation. (2015)
  • Author(s): Fukuhara K, Okura H, Neishi Y, Yoshida K, et al.
  • Organizer: 第79回日本循環器学会学術総会
  • Place of Presentation: グランフロント大阪北館B2階、ナレッジキャピタル コングレコンベンションセンター、大阪
  • Year and Date: 2015-04-26
• [Presentation] Clopidogrel Resistance And Intra-stent Thrombi Assessed By Optical Coherence Tomography After Drug-eluting Stent Implantation. (2014)
  • Author(s): Fukuhara K, Okura H, Neishi Y, Yoshida K, et al
  • Organizer: 63rd Annsual Scientific Sessions, American College of Cardiology
  • Place of Presentation: Walter E. Washington Convention Center、ワシントンDC, USA
  • Year and Date: 2014-04-01
• [Presentation] Clopidogrel resistance and intra-stent thrombi assessed by optical coherence tomography after drug-eluting stent implantation
  • Author(s): Kenzo Fukuhara, Hiroyuki Okura, Teruyoshi Kume, Terumasa Koyama, Yuzuru Iino, Ryotaro Yamada, Akihiro Hayashida, Yoji Neishi, Takahiro Kawamoto, Kiyoshi Yoshida
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京国際フォーラム, Tokyo, Japan
• [Presentation] Clopidogrel Resistance And Intra-stent Thrombi Assessed By Optical Coherence Tomography After Drug-eluting Stent Implantation
  • Author(s): Kenzo Fukuhara, Hiroyuki Okura, Teruyoshi Kume, Terumasa Koyama, Yuzuru Iino, Ryotaro Yamada, Akihiro Hayashida, Yoji Neishi, Takahiro Kawamoto, Kiyoshi Yoshida
  • Organizer: 63rd Annual Scientific Session, American College of Cardiology 2014
  • Place of Presentation: Washington Convention Center, Washington DC, USA