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Impact of residual platelet function on late stent thrombosis after drug-eluting stent implantation

Research Project

Project/Area Number 24591079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

OKURA Hiroyuki  川崎医科大学, 医学部, 准教授 (30425136)

Co-Investigator(Kenkyū-buntansha) YOJI Neishi  川崎医科大学, 医学部, 講師 (80319946)
KIYOSHI Yoshida  川崎医科大学, 医学部, 教授 (60322583)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsステント血栓症 / 光干渉断層法 / 冠動脈 / 血小板凝集 / クロピドグレル耐性 / 虚血性心疾患
Outline of Final Research Achievements

To clarify relationship between clopidogrel resistance and intra-stent thrombus formation following drug-eluting stent implantation, 152 stented lesions from 74 patients were enrolled and studied. At follow-up (mean 10 months) after stenting, intra-stent thrombus detected by optical coherence tomography was more frequently found in patients with clopidogrel resistance. In conclusion, clopidogrel resistance may be related to intra-stent thrombus formation after drug-eluting stent implantation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography2014

    • Author(s)
      Okura H,
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 11 Pages: 2622-2623

    • DOI

      10.1253/circj.CJ-14-1045

    • NAID

      130004693859

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Clopidogrel resistance and intra-stent thrombi assessed by optical coherence after drug-eluting stent implantation.2015

    • Author(s)
      Fukuhara K, Okura H, Neishi Y, Yoshida K, et al.
    • Organizer
      第79回日本循環器学会学術総会
    • Place of Presentation
      グランフロント大阪北館B2階、ナレッジキャピタル コングレコンベンションセンター、大阪
    • Year and Date
      2015-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clopidogrel Resistance And Intra-stent Thrombi Assessed By Optical Coherence Tomography After Drug-eluting Stent Implantation.2014

    • Author(s)
      Fukuhara K, Okura H, Neishi Y, Yoshida K, et al
    • Organizer
      63rd Annsual Scientific Sessions, American College of Cardiology
    • Place of Presentation
      Walter E. Washington Convention Center、ワシントンDC, USA
    • Year and Date
      2014-04-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clopidogrel resistance and intra-stent thrombi assessed by optical coherence tomography after drug-eluting stent implantation

    • Author(s)
      Kenzo Fukuhara, Hiroyuki Okura, Teruyoshi Kume, Terumasa Koyama, Yuzuru Iino, Ryotaro Yamada, Akihiro Hayashida, Yoji Neishi, Takahiro Kawamoto, Kiyoshi Yoshida
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム, Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Clopidogrel Resistance And Intra-stent Thrombi Assessed By Optical Coherence Tomography After Drug-eluting Stent Implantation

    • Author(s)
      Kenzo Fukuhara, Hiroyuki Okura, Teruyoshi Kume, Terumasa Koyama, Yuzuru Iino, Ryotaro Yamada, Akihiro Hayashida, Yoji Neishi, Takahiro Kawamoto, Kiyoshi Yoshida
    • Organizer
      63rd Annual Scientific Session, American College of Cardiology 2014
    • Place of Presentation
      Washington Convention Center, Washington DC, USA
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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