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Pressure Overload by Pneumonectomy Causes Right Ventricular Lethal Arrhythmias: Analysis by Optical Mapping

Research Project

Project/Area Number 24591081
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNational Defense Medical College

Principal Investigator

TAKASE Bonpei  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 准教授 (50518214)

Co-Investigator(Kenkyū-buntansha) ISHIHARA Masayuki  防衛医科大学校, 防衛医学研究センター, 教授 (10508500)
田中 良弘  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 教授 (50533981)
Co-Investigator(Renkei-kenkyūsha) TANAKA Yoshihiro  防衛医科大学校, 病院, 教授 (50533981)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords肺動脈高血圧 / 致死性不整脈 / 再分極異常 / 該当なし
Outline of Final Research Achievements

Right ventricular (RV) pressure overload due to severe pulmonary hypertension (svr-PH > 40 mmHg) sometimes causes lethal arrhythmias, although the mechanisms are unclear. To investigate if RV pressure overload produces RV arryhythmogenic vulnerability, we serially performed optical mapping analysis (OMP) with electrophysiological study (EPS) to the heart excised from pneumonectomy-induced (LP+H) svr-PH rats. Action potential duration dispersion (APDd) and connexin43 (Cx43) expression were measured in RV. LP+H-svr-PH transiently sustained. OMP revealed abnormal RV conduction and increased APDd accompanying ventricular fibrillation/tachycardia (VF/VT) induction by EPS with normal Cx-43 in LP+H -svr-PH. Conclusions; Transiently sustained (>24-hours) svr-PH can cause lethal arrhythmias possibly due to the mechanoelectric transduction not including Cx43degradation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (62 results)

All 2014 2013 2012

All Journal Article (26 results) (of which Peer Reviewed: 23 results) Presentation (34 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Fixed-dose combination of losartan and hydrochlorothiazide significantly improves endothelial function in uncontrolled hypertension by low-dose amlodipine: a randomized study.2014

    • Author(s)
      Takase B, Nagata M.
    • Journal Title

      Anadolu Kardiyol Derg.

      Volume: 14(8) Pages: 685-691

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autonomic nervous activation triggered during induction of reactive hyperemia exerts a greater influence on the measured reactive hyperemia index by peripheral arterial tonometry than on flow-mediated vasodilatation of the brachial artery in patients with hypertension.2014

    • Author(s)
      Tomiyama H, Yoshida M, Higashi Y, Takase B, Furumoto T, Kario K, Ohya Y, Yamashina A; sub-group study of FMD-J.
    • Journal Title

      Hypertens Res.

      Volume: 37(10) Pages: 914-918

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sudden cardiac arrest recorded during Holter monitoring: Prevalence, antecedent electrical events and outcomes.2014

    • Author(s)
      Watanabe E, Tanabe T, Osaka M, Chishaki A, Takase B, Niwano S, Watanabe I, Sugi K, Katoh T, Takayanagi K, Mawatari K, Horie M, Okumura K, Inoue H, Atarashi H, Yamaguchi I, Nagasawa S, Moroe K, Kodama I, Sugimoto T, Aizawa Y.
    • Journal Title

      Heart Rhythm

      Volume: Apr 30. Epub ahead of print Issue: 8 Pages: 1418-1425

    • DOI

      10.1016/j.hrthm.2014.04.036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significant association between periodontitis and cardiovascular risk.2014

    • Author(s)
      Kimura K, Takase B
    • Journal Title

      Circ J.2014

      Volume: 78(4) Pages: 837-838

    • NAID

      130003391063

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-sympathetic action enhances statin's pleiotropic effects: the combined effect of rosuvastatin and atenolol on endothelial function.2014

    • Author(s)
      Takase B, Hattori H, Tanaka Y, Nagata M, Ishihara M.
    • Journal Title

      Int Angiol

      Volume: 33(1) Pages: 27-34

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined therapeutic effect of probucol and cilostazol on endothelial function in patients with silent cerebral lacunar infarcts and hypercholesterolemia: a preliminary study.2014

    • Author(s)
      Takase B, Nagata M, Hattori H, Tanaka Y, Ishihara M.
    • Journal Title

      Med Princ Pract

      Volume: 23(1) Issue: 1 Pages: 59-65

    • DOI

      10.1159/000355825

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of heart rate variability in comparison with annual health examinations in very elderly subjects.2013

    • Author(s)
      Kurita A, Takase B, Kodani E, Iwahara S, Kusama Y, Atarashi H.
    • Journal Title

      J Nippon Med Sch.

      Volume: 80(6) Pages: 420-425

    • NAID

      130004147259

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women.2013

    • Author(s)
      Maruhashi T, Nakashima A, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y.
    • Journal Title

      BMJ Open

      Volume: 2013 Nov 8;3(11) Issue: 11 Pages: e003659-e003659

    • DOI

      10.1136/bmjopen-2013-003659

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute Effect of Whole-Body Periodic Acceleration on Brachial Flow-Mediated Vasodilatation Assessed by a Novel Semi-Automatic Vessel Chasing UNEXEF18G System.2013

    • Author(s)
      Takase B, Hattori H, Tanaka Y, Uehata A, Nagata M, Ishihara M, Fujita M.
    • Journal Title

      J Cardiovasc Ultrasound

      Volume: 21(3) Issue: 3 Pages: 130-136

    • DOI

      10.4250/jcu.2013.21.3.130

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study.2013

    • Author(s)
      Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Yamashina A, Higashi Y.
    • Journal Title

      Heart

      Volume: 99(24) Issue: 24 Pages: 1837-1842

    • DOI

      10.1136/heartjnl-2013-304739

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thrombus-targeted perfluorocarbon-containing liposomal bubbles for enhancement of ultrasonic thrombolysis: Invitro and invivo study2013

    • Author(s)
      Hagisawa K, Nishioka T, Suzuki R, Maruyama K, Takase B, Ishihara M, Kurita A, Yoshimoto N, Nishida Y, Iida K, Luo H, Siegel RJ.
    • Journal Title

      J Thromb Haemost.

      Volume: 11 Issue: 8 Pages: 1565

    • DOI

      10.1111/jth.12321

    • URL

      https://pure.teikyo.jp/en/publications/dc392940-d5d2-4677-9206-b513a883c744

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 出血性ショック心臓における致死性不整脈の機序に関する実験的検討―活動電位不均一性とConnexin 43変化について―2013

    • Author(s)
      高瀬凡平、東村悠子、木村一生、田中良弘、服部秀美、石原雅之
    • Journal Title

      Therapeutic Research

      Volume: 34(8) Pages: 1060-1066

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血管内皮機能指標の疾患別測定値変動に関する検討:心臓リハビリテーション効果に関して2013

    • Author(s)
      高瀬凡平、永田雅良、服部秀美、石原雅之
    • Journal Title

      心臓リハビリテーション

      Volume: 18(2) Pages: 231-235

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low fixed-dose combination of olmesartan and azelnidipine significantly improves endothelial function in uncontrolled hypertension by low dose amlodipine.2013

    • Author(s)
      Takase B, Nagata M.
    • Journal Title

      J Jpn Coron Assoc 2013

      Volume: 19(4) Pages: 333-338

    • NAID

      130004850447

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Original research Pitavastatin subacutely improves endothelial function and reduces inflammatory cytokines and chemokines in patients with hypercholesterolaemia.2013

    • Author(s)
      Takase B, Hattori H,Tanaka Y, Nagata M, Ishihara M.
    • Journal Title

      Heart Asia

      Volume: 5 Issue: 1 Pages: 1204-1209

    • DOI

      10.1136/heartasia-2013-010368

    • Related Report
      2013 Research-status Report
  • [Journal Article] Right Ventricular Electrical Remodeling and Arrhythmogenic Substrate in Rat Pulmonary Hypertension2013

    • Author(s)
      Tanaka Y, Takase B, Yao T, Ishihara M.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: Apr 19.Epub ahead of print

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electroconvulsive therapy-induced Wolff-Parkinson-White syndrome: a case report.2013

    • Author(s)
      Enomoto S, Yoshino A, Takase B, Kuwahara T, Tatsuzawa Y, Nomura S.
    • Journal Title

      Gen Hosp Psychiatry

      Volume: Mar 18. 2 Epub ahead of print Issue: 5 Pages: 575.e7-575.e8

    • DOI

      10.1016/j.genhosppsych.2013.02.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl peptidase-4 inhibitors attenuate endothelial function as evaluated by flow-mediated vasodilatation in type 2 diabetic patients.2013

    • Author(s)
      Ayaori M, Iwakami N, Uto-Kondo H, Sato H, Sasaki M, Komatsu T, Iizuka M, Takiguchi S, Yakushiji E, Nakaya K, Yogo M, Ogura M, Takase B, Murakami T, Ikewaki K.
    • Journal Title

      J Am Heart Assoc

      Volume: Jan 28;2(1) Issue: 1

    • DOI

      10.1161/jaha.112.003277

    • Related Report
      2012 Research-status Report
  • [Journal Article] Continuation of end-of-life care in a special elderly nursing home and the role of doctors2012

    • Author(s)
      Kurita A, Shinagawa N, Kodani E, Iwahara S, Takase B, Kusama Y, Atarashi H.
    • Journal Title

      Nihon Ronen Igakkai Zasshi

      Volume: 49(3): Pages: 336-343

    • NAID

      130004485821

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiogenesis following cell injection is induced by an excess inflammatory response coordinated by bone marrow cells.2012

    • Author(s)
      Hattori H, Amano Y, Habu-Ogawa Y, Ando T, Takase B, Ishihara M.
    • Journal Title

      Cell Transplant

      Volume: Nov 8. Epub ahead of print

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery.2012

    • Author(s)
      Tomiyama H, Kohro T, Higashi Y, Takase B, et al.
    • Journal Title

      Int Heart J.

      Volume: 53(3). Pages: 170-17

    • NAID

      130001914139

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Importance of platypnea orthodeoxia in the differential diagnosis of dyspnea.2012

    • Author(s)
      Takase B, Tanaka Y, Hattori H, Ishihara M
    • Journal Title

      Intern Med.

      Volume: 51(13) Pages: 1651-1652

    • NAID

      130002062219

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperbilirubinemia, Augmentation of Endothelial Function and Decrease in Oxidative Stress in Gilbert Syndrome.2012

    • Author(s)
      Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y.
    • Journal Title

      Circulation

      Volume: 126 Issue: 5 Pages: 598-603

    • DOI

      10.1161/circulationaha.112.105775

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock2012

    • Author(s)
      Nogami, Y
    • Journal Title

      Shock

      Volume: 38 Issue: 2 Pages: 159-164

    • DOI

      10.1097/shk.0b013e31825ad7af

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exercise stress testing as the significant clinical modality for management of hypertension.2012

    • Author(s)
      Takase B.
    • Journal Title

      Hypertens Res.

      Volume: 35(7) Issue: 7 Pages: 706-707

    • DOI

      10.1038/hr.2012.47

    • NAID

      10030956750

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肺全摘手術術後の右心室負荷による催不整脈性に関する検討2012

    • Author(s)
      髙瀬凡平、田中良弘、東村悠子、服部秀美、石原雅之、浜部晃、永井智雄
    • Journal Title

      Therapeutic Research

      Volume: 33(11) Pages: 1616-1621

    • Related Report
      2012 Research-status Report
  • [Presentation] Possible favorable marker of positive head-up tilt and negative T-wave alternans during test in suspected high risk reflex syncope patients2014

    • Author(s)
      B Takase
    • Organizer
      American Heart Association Scientific Session 2014
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cardiac autonomic activity, cardiac function and arrhythmogenic property in hemorrhagic shock heart: Effect of artificial oxygen carrier2014

    • Author(s)
      B Takase, Y Tanaka
    • Organizer
      American Heart Association Scientific Session 2014
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Possible Favorable Marker of Positive Head-up Tilt and Negative T-Wave Alternans during Test in Suspected High Risk Reflex Syncope Patients and the Role of Daily Autonomic Activity in the Reflex Syncope Assessed by Heart Rate Variability2014

    • Author(s)
      B Takase, A Hamabe, T Nagai, H Tabata
    • Organizer
      第9回田原アショフシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] T-wave Alternans during Head-up Tilt Testing in Suspected High Risk Reflex Syncope Patients2014

    • Author(s)
      B Takase, A Hamabe, T Nagai, H Tabata
    • Organizer
      第29回日本不整脈学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Impaired Right Ventricular Function Assessed by Echocardiography in Persistent Atrial Fibrillation with Preserved Left Ventricular Function: Possible Indication for Ablation2014

    • Author(s)
      B Takase, T Kawai, M Nagata
    • Organizer
      第29回日本不整脈学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of calcium-channel blocker on T-wave alternans in coronary artery disease with silent myocardial ischemia and premature ventricular beats2014

    • Author(s)
      B Takase, A Kurita, A Hamabe, T Nagai, H Tabata
    • Organizer
      第29回日本不整脈学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Arrhythmogenic Substrate in Hemorrhagic Shock-Induced Heart and Effect of Artificial Blood2014

    • Author(s)
      B Takase, Y Tanaka, M Ishihara
    • Organizer
      Heart Rhythm 2014
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-05-07 – 2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Impaired Right Ventricular Function Assessed by Echocardiography in Persistent Atrial Fibrillation with Preserved Left Ventricular Function: Possible Indication for Ablation2014

    • Author(s)
      B Takase, T Kawai, M Nagata
    • Organizer
      第79回日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 器質的心疾患を伴わない若年運動誘発性失神症例の予後とHead-up tilt 試験中の T-wave alternans に関する 検討2014

    • Author(s)
      高瀬凡平, 木村一生, 浜部晃, 永井智雄, 田畑博嗣
    • Organizer
      第41 回日本集中治療医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Myocardial Electrical Remodeling and Arrhythmogenic Substrate in Hemorrhagic Shock- Induced Heart2013

    • Author(s)
      B. Takase, Y. Tanaka
    • Organizer
      American Heart Association Scientific Sessions 2013
    • Place of Presentation
      Dallas,Texas
    • Related Report
      2013 Research-status Report
  • [Presentation] Pressure Overload Causes Right Ventricular Lethal Arrhythmias:Analysis by Optical Mapping in Pulmonary Artery Banding and Pneumonectomy Model2013

    • Author(s)
      B. Takase, Y. Tanaka
    • Organizer
      American Heart Association Scientific Sessions 2013
    • Place of Presentation
      Dallas,Texas
    • Related Report
      2013 Research-status Report
  • [Presentation] Decreased endothelial nitric oxide production is more closely related with framigham risk than CHA2DS2-VASc scores in paroxysmal atrial fibrillation2013

    • Author(s)
      Bonpei Takase
    • Organizer
      The 6th Asia Pacific Heart Rhythm Society Scientific Sessions
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Research-status Report
  • [Presentation] What is the Latest Guidelines, Algorithms of Management of Syncope?2013

    • Author(s)
      Bonpei Takase
    • Organizer
      The 6th Asia Pacific Heart Rhythm Society Scientific Sessions
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Research-status Report
  • [Presentation] 冠動脈疾患を合併した糖尿病症例におけるDPP-4 阻害薬の血管内皮機能に及ぼす 影響;Preliminary Study2013

    • Author(s)
      高瀬凡平, 東村悠子, 永田雅良
    • Organizer
      第27 回日本冠疾患学会学術集会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Research-status Report
  • [Presentation] 出血性ショック心臓における致死性不整脈発生機序及 び人工酸素運搬体による治療 効果に関する検討2013

    • Author(s)
      高瀬凡平, 東村悠子, 田中良弘, 木下学
    • Organizer
      第20 回日本血液代替物学会年次大会
    • Place of Presentation
      奈良
    • Related Report
      2013 Research-status Report
  • [Presentation] Right Ventricular Failure and Arrhyth- mogenesis;Analysis by Optical Mapping in Monocrotaline-Induced Rat Pulmonary Hyperten- sion(右心不全と不整脈発生の機序; 肺高血圧実験モデルにおける光工学的解析による検討)2013

    • Author(s)
      Bonpei Takase, Yoshihiro Tanaka, Masayuki Ishihara
    • Organizer
      第17 回日本心不全学会学術集会
    • Place of Presentation
      さいたま市大宮
    • Related Report
      2013 Research-status Report
  • [Presentation] 反射性失神の特徴を有する運動誘発性失神例のT-wave alternans に関する検討2013

    • Author(s)
      高瀬凡平, 浜部晃, 永井知雄, 田畑博嗣, 栗田明
    • Organizer
      第30 回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 多施設FMD-J 研究プロトコールの概要についてProtocol on“A Multi- center Study to Evaluate Clinical Usefulness of the Semi-automated Measurement of Flow-mediated Vasodilatation of Brachial- artery in Japan:FMD-J Study"2013

    • Author(s)
      高瀬凡平, FMD-J共同研究者
    • Organizer
      第36 回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] DPP-4 阻害薬の血管 内皮機能に及ぼす影響;EndoPAT2000 測定法による解析2013

    • Author(s)
      高瀬凡平, 東村悠子, 蓮見有紀, 永田雅良
    • Organizer
      第28 回日本糖尿病合併症学会
    • Place of Presentation
      旭川
    • Related Report
      2013 Research-status Report
  • [Presentation] 肺手術術後及び肺動脈狭窄に伴う右心室負荷時の催不整脈性に関する検討2013

    • Author(s)
      高瀬凡平, 田中良弘, 服部秀美, 石原雅之
    • Organizer
      第61 回日本心臓病学会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 若年者運動誘発性失神症例のHead-up tilt 試験中のT-wave alternans に関す る検討2013

    • Author(s)
      高瀬凡平, 浜部晃, 永井知雄, 田畑博嗣, 栗田明
    • Organizer
      第61 回日本心臓病学会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] Endothelial Nitric Oxide Production and CHA2DS2-VASc Scores in Paroxysmal Atrial Fibrillation Compared with Framigham Risks2013

    • Author(s)
      Bonpei Takase, Masayoshi Nagata, Akira Hamabe, Tomoo Nagai
    • Organizer
      The 28th Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Pressure Overload Causes Right Ventricular Lethal Arrhythmias in Pulmonary Artery Banding and Pneumonectomy Model2013

    • Author(s)
      Bonpei Takase, Yoshihiro Tanaka, Hidemi Hattori, Masayuki Ishihara
    • Organizer
      The 28th Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Significant Role of Action Potential Duration Dispersion and Connexin43 in Lethal Arrhythmogenesis in Hemorrhagic Shock Heart2013

    • Author(s)
      Bonpei Takase, Yoshihiro Tanaka, Yuko Higshimura, Hidemi Hattori, Masayuki Ishihara
    • Organizer
      The 28th Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Right ventricularelectrical remodeling and arrhythmogenic substratein monocrotaline-inducedRat pulmonary hypertension and right ventricularfailure2013

    • Author(s)
      Takase B, Tanaka Y,Ishihara M
    • Organizer
      American College of Cardiology 2013, 62th Annual Scientic Session
    • Place of Presentation
      San Francisco
    • Related Report
      2012 Research-status Report
  • [Presentation] Abnormal action potential duration dispersion and impaired connexin43 are significant in lethal arrhythmias in hemorrhagic shock heart2013

    • Author(s)
      Takase B, Tanaka Y, Hattori H, Ishihara M
    • Organizer
      The 77th Annual Scientic Meeting of theJapanese Circulation Society
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Research-status Report
  • [Presentation] Pressure overload causes right ventricular lethal arrhythmias through possible mechanoelectrical transduction mechanisms: analysis in pulmonary artery banding and pumonectomy model2013

    • Author(s)
      Takase B, Tanaka Y, Hattori H, Ishihara M
    • Organizer
      The 77th Annual Scientic Meeting of theJapanese Circulation Society
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Research-status Report
  • [Presentation] Right ventricular electrical remodeling and arrhythmogenic substrate in monocrotaline-induced rat pulmonary hypertension; significance of increased action potential duration dispersion2013

    • Author(s)
      Takase B, Tanaka Y, Hattori H, Ishihara M
    • Organizer
      The 77th Annual Scientic Meeting of theJapanese Circulation Society
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Research-status Report
  • [Presentation] 出血性ショックにおける致死性不整脈発生機序に関する実験的検討2013

    • Author(s)
      高瀬凡平, 田中良弘, 東村悠子, 服部秀美, 木村一生, 石原雅之
    • Organizer
      第40 回日本集中治療医学会学術集会総会
    • Place of Presentation
      松本
    • Related Report
      2012 Research-status Report
  • [Presentation] 出血性ショック心における致死性不整脈と酸素化Hemoglobin の有効性2013

    • Author(s)
      田中良弘, 高瀬凡平, 中山健史, 藤田真敬, 服部秀美, 石原雅之
    • Organizer
      第58 回防衛衛生学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Right ventricular electrical remodeling and arrhythmogenic substrate in rat pulmonary hypertension2012

    • Author(s)
      Takase B, Tanaka Y, Ishihara M
    • Organizer
      5th Asia Pasic Heart Rhythm Society Scientific Session
    • Place of Presentation
      Taipei
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Monocrotaline 誘発肺高血圧モデルにおけるSildenaphil とBeraprost の併用療法の効果:Optical Mapping Analysis による検討2012

    • Author(s)
      高瀬凡平, 田中良弘, 服部秀美, 石原雅之
    • Organizer
      第28 回心電情報処理ワークショップ
    • Place of Presentation
      熱海
    • Related Report
      2012 Research-status Report
  • [Presentation] 出血性ショック心臓における致死性不整脈発生の病態に関する実験的検討2012

    • Author(s)
      高瀬凡平, 東村悠子, 田中良弘, 服部秀美, 石原雅之
    • Organizer
      第27 回日本不整脈学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺高血圧による右心負荷時の致死的催不整脈性機序の検討:実験的肺高血圧モデルでの解析2012

    • Author(s)
      高瀬凡平, 東村悠子, 田中良弘, 服部秀美, 石原雅之
    • Organizer
      第27 回日本不整脈学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] 今日の循環器疾患治療指針2013

    • Author(s)
      高瀬凡平
    • Total Pages
      938
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 血圧2013

    • Author(s)
      高瀬凡平
    • Total Pages
      85
    • Publisher
      ㈱先端医学社
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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