Pressure Overload by Pneumonectomy Causes Right Ventricular Lethal Arrhythmias: Analysis by Optical Mapping
| Project/Area Number |
24591081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Defense Medical College |
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Principal Investigator |
TAKASE Bonpei 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 准教授 (50518214)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Masayuki 防衛医科大学校, 防衛医学研究センター, 教授 (10508500)
田中 良弘 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 教授 (50533981)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Yoshihiro 防衛医科大学校, 病院, 教授 (50533981)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 肺動脈高血圧 / 致死性不整脈 / 再分極異常 / 該当なし |
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| Outline of Final Research Achievements |
Right ventricular (RV) pressure overload due to severe pulmonary hypertension (svr-PH > 40 mmHg) sometimes causes lethal arrhythmias, although the mechanisms are unclear. To investigate if RV pressure overload produces RV arryhythmogenic vulnerability, we serially performed optical mapping analysis (OMP) with electrophysiological study (EPS) to the heart excised from pneumonectomy-induced (LP+H) svr-PH rats. Action potential duration dispersion (APDd) and connexin43 (Cx43) expression were measured in RV. LP+H-svr-PH transiently sustained. OMP revealed abnormal RV conduction and increased APDd accompanying ventricular fibrillation/tachycardia (VF/VT) induction by EPS with normal Cx-43 in LP+H -svr-PH. Conclusions; Transiently sustained (>24-hours) svr-PH can cause lethal arrhythmias possibly due to the mechanoelectric transduction not including Cx43degradation.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Sudden cardiac arrest recorded during Holter monitoring: Prevalence, antecedent electrical events and outcomes.2014
Author(s)
Watanabe E, Tanabe T, Osaka M, Chishaki A, Takase B, Niwano S, Watanabe I, Sugi K, Katoh T, Takayanagi K, Mawatari K, Horie M, Okumura K, Inoue H, Atarashi H, Yamaguchi I, Nagasawa S, Moroe K, Kodama I, Sugimoto T, Aizawa Y.
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Journal Title
Heart Rhythm
Volume: Apr 30. Epub ahead of print
Issue: 8
Pages: 1418-1425
DOI
Related Report
Peer Reviewed
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[Journal Article] Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women.2013
Author(s)
Maruhashi T, Nakashima A, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y.
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Journal Title
BMJ Open
Volume: 2013 Nov 8;3(11)
Issue: 11
Pages: e003659-e003659
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study.2013
Author(s)
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Yamashina A, Higashi Y.
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Journal Title
Heart
Volume: 99(24)
Issue: 24
Pages: 1837-1842
DOI
Related Report
Peer Reviewed
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[Journal Article] Thrombus-targeted perfluorocarbon-containing liposomal bubbles for enhancement of ultrasonic thrombolysis: in vitro and in vivo study.2013
Author(s)
Hagisawa K, Nishioka T, Suzuki R, Maruyama K, Takase B, Ishihara M, Kurita A, Yoshimoto N, Nishida Y, Iida K, Luo H, Siegel RJ.
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Journal Title
J Thromb Haemost.
Volume: 11
Issue: 8
Pages: 1565-1573
DOI
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Peer Reviewed
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[Journal Article] Dipeptidyl peptidase-4 inhibitors attenuate endothelial function as evaluated by flow-mediated vasodilatation in type 2 diabetic patients.2013
Author(s)
Ayaori M, Iwakami N, Uto-Kondo H, Sato H, Sasaki M, Komatsu T, Iizuka M, Takiguchi S, Yakushiji E, Nakaya K, Yogo M, Ogura M, Takase B, Murakami T, Ikewaki K.
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Journal Title
J Am Heart Assoc
Volume: Jan 28;2(1)
Issue: 1
DOI
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[Journal Article] Hyperbilirubinemia, Augmentation of Endothelial Function and Decrease in Oxidative Stress in Gilbert Syndrome.2012
Author(s)
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y.
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Journal Title
Circulation
Volume: 126
Issue: 5
Pages: 598-603
DOI
Related Report
Peer Reviewed
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[Book] 血圧2013
Author(s)
高瀬凡平
Total Pages
85
Publisher
㈱先端医学社
Related Report
