The relationships of vascular endothelial growth factor-C with atherosclerosis and cardiovascular events

• Project/Area Number: 24591082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: WADA Hiromichi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 研究室長(先端医療技術開発) (20416209)
• Co-Investigator(Kenkyū-buntansha): SATOH Noriko 独立行政法人国立病院機構, 京都医療センター臨床研究センター・糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 動脈硬化 / 心血管病

Outline of Final Research Achievements

We previously demonstrated that vascular endothelial growth factor-C (VEGF-C), a lymphangiogenic factor, is closely associated with dyslipidemia and atherosclerosis. Immunohistochemistry in human carotid atheromatous plaque revealed that lymphatics were rare in the plaque. However, an administration of recombinant VEGF-C protein did not affectthe plaque size in the mouse model of atherosclerosis. On the other hand, serum levels of VEGF-C were inversely associated with future cardiovascular events not only in patients with arteriosclerosis obliterans, but also in those receiving coronary drug-eluting stent implantation. These findings suggest that a low VEGF-C value may serve as a predictor of cardiovascular events.

Research Products

• [Presentation] Serum Vascular Endothelial Growth Factor-C Levels Inversely Associated with Risk of Cardiovascular Events in Arteriosclerotic Obliterans (2015)
  • Author(s): Nobutoyo Masunaga, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Akira Yamada, Mitsuru Abe, Mitsuru Ishii, Takashi Unoki, Moritake Iguchi, Yugo Yamashita, Yasuhiro Hamatani, Hisashi Ogawa, Daisuke Takagi, Noriko Asahara3, Akira Shimatsu, Koji Hasegawa
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Pre-procedural Serum Vascular Endothelial Growth Factor-C Levels Inversely Associated with Risk of Cardiac and Cerebrovascular Events after Drug-eluting Stent Implantation (2015)
  • Author(s): Takashi Unoki, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Akira Yamada, Yugo Yamashita, Yasuhiro Hamatani, Nobutoyo Masunaga, Mitsuru Ishii, Mitsuru Abe, Moritake Iguchi, Hisashi Ogawa, Daisuke Takagi, Noriko Asahara, Akira Shimatsu, Koji Hasegawa
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Serum Vascular Endothelial Growth Factor-C Levels are Inversely Associated with the Risk of Cardiac and Cerebrovascular Events Following Drug-eluting Stent Implantation (2014)
  • Author(s): Takashi Unoki, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Akira Yamada, Kensuke Takabayashi, Yugo Yamashita, Yasuhiro Hamatani, Nobutoyo Masunaga, Mitsuru Ishii, Moritake Iguchi, Hisashi Ogawa, Daisuke Takagi, Noriko Satoh-Asahara, Akira Shimatsu, and Koji Hasegawa
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2014-11-16 – 2014-11-19
• [Presentation] Serum Vascular Endothelial Growth Factor-C Levels are Inversely Associated With Major Adverse Cardiovascular Events in Patients With Arteriosclerotic Obliterans (2014)
  • Author(s): Nobutoyo Masunaga, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Akira Yamada, Mitsuru Abe, Mitsuru Ishii, Takashi Unoki, Moritake iguchi, Yugo Yamashita, Yasuhuro Hamatani, Hisashi Ogawa, Daisuke Takagi, Noriko Satoh-Asahara, Akira Shimatu, and Koji Hasegawa
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2014-11-16 – 2014-11-19
• [Presentation] Vascular Endothelial Growth Factor-C, Dyslipidemia, and Atherosclerosis (2013)
  • Author(s): Shuichi Ura, Hiromichi Wada, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Akira Shimatsu, Koji Hasegawa
  • Organizer: 18th Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy
  • Place of Presentation: Roma, Italy
• [Presentation] 男性における血清VEGF-Cレベルと冠動脈疾患重症度の関連 (2013)
  • Author(s): 鵜木 崇, 和田 啓道, 赤尾 昌治, 浦 修一, 益永 信豊, 石井 充, 阿部 充, 小川 尚, 井口 守丈, 高林 健介, 山下 侑吾, 濱谷 康弘, 浅原 哲子, 島津 章, 長谷川 浩二
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] 男性において血清VEGF-C レベルは冠動脈疾患重症度と逆相関する (2013)
  • Author(s): 鵜木 崇, 和田 啓道, 赤尾 昌治, 浦 修一, 益永 信豊, 石井 充, 阿部 充, 小川 尚, 井口 守丈, 高林 健介, 島津 章, 長谷川 浩二
  • Organizer: 第45回日本動脈硬化学会
  • Place of Presentation: 東京
• [Presentation] 血清VEGF-Cレベルと冠動脈疾患重症度との関連 (2013)
  • Author(s): 鵜木 崇、和田 啓道、赤尾 昌治、浦 修一、益永 信豊、石井 充、 阿部 充、小川 尚、井口 守丈、高林 健介、中島 康代、浅原 哲子、島津 章、長谷川 浩二
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
• [Presentation] Serum Levels of Vascular Endothelial Growth Factor-C are Inversely Correlated with Future Cardiovascular Events (2012)
  • Author(s): Nobutoyo Masunaga, Hiromichi Wada, Masaharu Akao, Shuichi Ura, et al.
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angeles CA USA
• [Presentation] Serum Levels of VEGF-C, but not VEGF-A, are Inversely Correlated with Systolic Dysfunction (2012)
  • Author(s): Mitsuru Ishii, Hiromichi Wada, Masaharu Akao, Shuichi Ura, et al.
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angeles CA USA
• [Presentation] Inverse Correlation between Serum VEGF-C Levels and the Severity of Coronary Artery Disease in Men
  • Author(s): Takashi Unoki, Hiromichi Wada, Masaharu Akao, Suichi Ura, Nobutoyo Masunaga, Mitsuru Ishii, Mitsuru Abe, Moritake Iguchi, Kensuke Takabayashi,
  • Organizer: 第115回日本循環器学会近畿地方会
  • Place of Presentation: 京都