Role of HMGB1 protein in the pathogenesis of abdominal aortic aneurysm
| Project/Area Number |
24591083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
ANZAI Toshihisa 独立行政法人国立循環器病研究センター, 病院, 部長 (60232089)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 循環器・高血圧 / 蛋白質 / 病理学 / 免疫学 |
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| Outline of Final Research Achievements |
High-mobility group box 1 protein (HMGB1) is a non-histone DNA binding protein and a potent inducer of inflammatory response. We investigated the role of HMGB1 in a mouse CaCl2-induced abdominal aortic aneurysm (AAA) model. Administration of neutralizing anti-HMGB1 antibody for 6 weeks resulted in suppression of AAA formation, inflammatory cellular infiltration, and elastin fragmentation, in association with decreased expression of HMGB1, infiltration of Mac-3 positive macrophages, activity of MMP-2 and MMP-9, and mRNA expression of tumor necrosis factor-α, CD68 and MCP-1 in the aorta. These findings suggest a significant role of HMGB1 in the pathogenesis of AAA through enhanced inflammatory response.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations.2015
Author(s)
Miyamoto K, Aiba T, Kimura H, Hayashi H, Ohno S, Yasuoka C, Tanioka Y, Tsuchiya T, Yoshida Y, Hayashi H, Tsuboi I, Nakajima I, Ishibashi K, Okamura H, Noda T, Ishihara M, Anzai T, Yasuda S, Miyamoto Y, Kamakura S, Kusano K, Ogawa H, Horie M, Shimizu W.
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Journal Title
Heart Rhythm
Volume: 12
Issue: 3
Pages: 596-603
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Admission hyperglycemia is an independent predictor of acute kidney injury in patients with acute myocardial infarction.2014
Author(s)
Moriyama N, Ishihara M, Noguchi T, Nakanishi M, Arakawa T, Asaumi Y, Kumasaka L, Kanaya T, Miyagi T, Nagai T, Yamane T, Fujino M, Honda S, Fujiwara R, Anzai T, Goto Y, Yasuda S, Ogawa H.
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Journal Title
Circ J
Volume: 78
Pages: 1475-1480
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extensive late gadolinium enhancement on cardiovascular magnetic resonance predicts adverse outcomes and lack of improvement in left ventricular function after steroid therapy in cardiac sarcoidosis.2014
Author(s)
Ise T, Hasegawa T, Morita Y, Yamada N, Funada A, Amaki M, Kanzaki H, Okamura H, Kamakura S, Shimizu W, Anzai T, Kitakaze M.
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Journal Title
Heart
Volume: 100
Issue: 15
Pages: 1165-1172
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased myocardial dendritic cells is associated with impaired reparative fibrosis and development of cardiac rupture after myocardial infarction in humans.2014
Author(s)
Nagai T, Honda S, Sugano Y, Matsuyama T, Ohta-Ogo K, Asaumi Y, Ikeda Y, Kusano K, Ishihara M, Yasuda S, Ogawa H, Ishibashi-Ueda H, Anzai T.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years.2014
Author(s)
Honda S, Asaumi Y, Yamane T, Nagai T, Miyagi T, Noguchi T, Anzai T, Goto Y, Ishihara M, Ogawa H, Ishibashi-Ueda H, Yasuda S.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pathophysiological impact of serum fibroblast growth factor 23 in patients with nonischemic cardiac disease and early chronic kidney disease.2014
Author(s)
Imazu M, Takahama H, Asanuma H, Funada A, Sugano Y, Ohara T, Hasegawa T, Asakura M, Kanzaki H, Anzai T, Kitakaze M.
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 307(10)
Issue: 10
Pages: H1504-H1511
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Impact of acute and chronic hyperglycemia on in-hospital outcomes of patients with acute myocardial infarction.2014
Author(s)
Fujino M, Ishihara M, Honda S, Kawakami S, Yamane T, Nagai T, Nakao K, Kanaya T, Kumasaka L, Asaumi Y, Arakawa T, Tahara Y, Nakanishi M, Noguchi T, Kusano K, Anzai T, Goto Y, Yasuda S, Ogawa H.
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Journal Title
Am J Cardiol
Volume: 114
Issue: 12
Pages: 1789-1793
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hemoglobin A1c predicts heart failure hospitalization independent of baseline cardiac function or B-type natriuretic peptide level.2014
Author(s)
Kishimoto I, Makino H, Ohta Y, Tamanaha T, Tochiya M, Kada A, Ishihara M, Anzai T, Shimizu W, Yasuda S, Ogawa H.
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Journal Title
Diabetes Res Clin Pract
Volume: 104
Issue: 2
Pages: 257-265
DOI
Related Report
Peer Reviewed
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[Journal Article] Left circumflex coronary artery is protected against no-reflow phenomenon following percutaneous coronary intervention for coronary artery disease.2013
Author(s)
Nagai T, Hirano T, Tsunoda M, Hosaka H, Kishino Y, Katayama T, Matsumura K, Miyagawa T, Kohsaka S, Anzai T, Fukuda K, Suzuki M.
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Journal Title
Heart Vessels
Volume: 28
Issue: 5
Pages: 559-565
DOI
Related Report
Peer Reviewed
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[Journal Article] Electrocardiographic predictors of response to cardiac resynchronization therapy in patients with intraventricular conduction delay.2013
Author(s)
Takaya Y, Noda T, Nakajima I, Yamada Y, Miyamoto K, Okumura H, Satomi K, Aiba T, Kusano KF, Kanzaki H, Anzai T, Ishihara M, Yasuda S, Ogawa H, Kamakura S, Shimizu W.
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Journal Title
Circ J
Volume: 78
Pages: 71-77
NAID
Related Report
Peer Reviewed
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[Journal Article] The extent of heart rate reduction during hospitalization using beta-blockers, not the achieved heart rate itself at discharge, predicts the clinical outcome in patients with acute heart failure syndromes.2013
Author(s)
Takahama H, Yokoyama H, Kada A, Sekiguchi K, Fujino M, Funada A, Amaki M, Hasegawa T, Asakura M, Kanzaki H, Anzai T, Kitakaze M.
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Journal Title
J Cardiol
Volume: 61
Issue: 1
Pages: 58-64
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of preoperative evaluation by multidetector computed tomography in percutaneous coronary interventions of chronic total occlusions.2012
Author(s)
Ueno K, Kawamura A, Onizuka T, Kawakami T, Nagatomo Y, Hayashida K, Yuasa S, Maekawa Y, Anzai T, Jinzaki M, Kuribayashi S, Ogawa S.
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Journal Title
Int J Cardiol
Volume: 156
Issue: 1
Pages: 76-79
DOI
Related Report
Peer Reviewed
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[Presentation] Not intermediate but high sgnal-intensity late gadolinium enhancement predict major adverse cardiovascular events in hypertrophic cardiomyopathy: result from longitudinal study.2013
Author(s)
Funada A, Kanzaki H, Noguchi T, Sugano Y, Ohhara T, Hasegawa T, Morita Y, Ishihara M, Shimizu W, Ogawa H, Yasuda S, Kitakaze M, Anzai T.
Organizer
第７７回日本循環器学会総会
Place of Presentation
横浜
Related Report
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[Presentation] Impact of lymphocyte subset on long-term prognosis in patients with acute decompensated heart failure.2013
Author(s)
Nagai T, Anzai T, Yokoyama H, Sugano Y, Funada A, Ohhara T, Hasegawa T, Kanzaki H, Ishihara M, Shimizu W, Yasuda S, Ogawa H.
Organizer
第７７回日本循環器学会総会
Place of Presentation
横浜
Related Report
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[Presentation] Impact of the polymorphisms of renin-angiotensin system on prognosis in hypertrophic cardiomyopathy in the era of cardiac magnetic resonance.2013
Author(s)
Funada A, Kanzaki H, Yamazaki S, Hasegawa T, Sugano Y, Ohhara T, Asakura M, Ishihara M, Yasuda S, Shimizu W, Ogawa H, Kitakaze M, Anzai T.
Organizer
第７７回日本循環器学会総会
Place of Presentation
横浜
Related Report
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