| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
High-mobility group box 1 protein (HMGB1) is a non-histone DNA binding protein and a potent inducer of inflammatory response. We investigated the role of HMGB1 in a mouse CaCl2-induced abdominal aortic aneurysm (AAA) model. Administration of neutralizing anti-HMGB1 antibody for 6 weeks resulted in suppression of AAA formation, inflammatory cellular infiltration, and elastin fragmentation, in association with decreased expression of HMGB1, infiltration of Mac-3 positive macrophages, activity of MMP-2 and MMP-9, and mRNA expression of tumor necrosis factor-α, CD68 and MCP-1 in the aorta. These findings suggest a significant role of HMGB1 in the pathogenesis of AAA through enhanced inflammatory response.
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