| Project/Area Number |
24591093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Asahi University (2013-2014)
Gifu University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAMORI Hiromitsu 岐阜大学, 医学部附属病院, 講師 (20456502)
高橋 知之 久留米大学, 医学部, 准教授 (20332687)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Tomoyuki 久留米大学, 医学部, 准教授 (20332687)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Cell therapy / Heart failure / Integrins / Myocardial infarction / Remodeling / 心筋梗塞 / リモデリング / 細胞移植 / 遺伝子治療 |
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| Outline of Final Research Achievements |
The aim of the present study was to prevent the postinfarction left ventricular remodeling and heart failure by autologous cell transplantation. We are performing the experiments in which we intravenously inject the skin-derived myofibroblasts overexpressing integrin beta1 to the mice bearing a large myocardial infarction. Although the results are not conclusive yet, we obtained an excellent results in another similar study in which the intravenously injected endothelial progenitor cells overexpressing integrin beta1 greatly improved the blood flow of ischemic legs of mice.
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