Insulin signaling as a therapeutic target of heart failure
Project/Area Number |
24591094
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
SHIOI Tetsuo 京都大学, 医学(系)研究科(研究院), 講師 (50360095)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 心不全 / インスリン / ミトコンドリア / 悪液質 |
Outline of Final Research Achievements |
Heart failure (HF) is associated with changes in energy metabolism of the heart, as well as in extra-cardiac organs such as skeletal muscles. We tested the hypothesis that BCAA ameliorate HF. We used Dahl salt-sensitive (DS) rats fed a high-salt diet as a model of HF. In HF rats, BCAA treatment decreased the heart rate, preserved the cardiac function, and prolonged survival. BCAA also prevented body weight loss, associated with preservation of the skeletal muscle weight. Moreover, the decrease of gene expression related to mitochondrial biogenesis and function was prevented by BCAA in skeletal muscles. In conclusion, BCAA ameliorated HF in a rat model.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure2015
Author(s)
Kawamoto A, Kato T, Shioi T, Okuda J, Kawashima T. Tamaki Y, Niizuma S, Tanada Y, Takemura G, Narazaki M, Matsuda T, Kimura T
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Journal Title
PLoS One.
Volume: 10
Issue: 1
Pages: e0117091-e0117091
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes2014
Author(s)
Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED
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Journal Title
Mol Cell Biol.
Volume: 35
Issue: 5
Pages: 831-846
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice2013
Author(s)
Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.
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Journal Title
PLoS ONE
Volume: 8
Issue: 8
Pages: e72173-e72173
DOI
Related Report
Peer Reviewed
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[Journal Article] Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts2013
Author(s)
Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Horie T, Morooka H, Takase T, Akahashi Y, Kobuke K, Ono K, Shioi T, Sheikh SP, Ambartsumian N, Lukanidin E, Koshimizu TA, Miyazaki S, Kimura T
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Journal Title
J Mol Cell Cardiol
Volume: 57
Pages: 72-81
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of liver metabolism in a rat model of heart failure.2012
Author(s)
Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Kawamoto A, Tamaki Y, Iwanaga Y, Soga T, Kita T, Kimura T, Shioi T.
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Journal Title
Int J Cardiol.
Volume: 161
Pages: 130-136
Related Report
Peer Reviewed
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[Journal Article] Effect of persistent activation of phosphoinositide 3-kinase on heart.2012
Author(s)
Niizuma S, Inuzuka Y, Okuda J, Kato T, Kawashima T, Tamaki Y, Iwanaga Y, Yoshida Y, Kosugi R, Watanabe-Maeda K, Machida Y, Tsuji S, Aburatani H, Izumi T, Kita T, Kimura T, Shioi T.
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Journal Title
Life Sci.
Volume: 90
Pages: 619-628
Related Report
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[Presentation] Tc-99m Sestamibi washout is a useful method to assess cardiac mitochondrial function and the increased risk of a failing heart: a translational approach to understand the metabolic state of the heart.2012
Author(s)
Kato T, Shioi T, Kawamoto A, Kimura T, Nagakura D, Nakane E, Miyamoto S, Izumi T, Haruna T, Inoko T, Nohara R.
Organizer
The 84th Scientific Sessions of American Heart Association
Place of Presentation
Los Angeles, USA
Related Report
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