| Project/Area Number |
24591098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYANAGI Masamichi 九州大学病院別府病院, 内科, 助教 (00325474)
MAEDA Toyoki 九州大学病院別府病院, 内科, 准教授 (30264112)
MAKINO Naoki 九州大学病院別府病院, 内科, 名誉教授 (60157170)
新留 琢郎 熊本大学, 自然科学研究科, 教授 (20264210)
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| Co-Investigator(Renkei-kenkyūsha) |
NIIDOME Takuro 熊本大学, 自然科学研究科, 教授 (20264210)
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| Research Collaborator |
TSUCHIDA Keiko
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 金ナノロッド / 心不全 / 温熱療法 / 循環器 / ナノテクノロジー / トランスジェニックマウス / サイトカイン / 心臓局所温熱 / 近赤外線レーザー |
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| Outline of Final Research Achievements |
Gold nanorods (GNRs), rod-shaped gold nanoparticles, act as both contrast agents for in vivo bioimaging and thermal converters for photothermal therapy to treat inflammatory disorders. Pro-inflammatory cytokines play critical roles in the development of heart failure. We herein examined the delivery of GNRs into the inflammatory heart in a transgenic mouse (TG) model of inflammatory cardiomyopathy with the cardiac specific overexpression of TNF-α. We modified GNRs with polyethylene glycol (PEGylated GNRs) to avoid cytotoxicity and reduce the rapid clearance of nanoparticles from the blood. PEGylated GNRs were administered intravenously in TG and wild-type mice. A quantitative analysis of Au was performed using inductively coupled plasma mass spectrometry (ICP-MS). Approximately twice more Au was detected in the TG heart. We herein demonstrated that PEGylated GNRs are prone to accumulate in the heart with inflammatory cardiomyopathy.
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