The roles of macrophage polarization in vascular remodeling
Project/Area Number |
24591109
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | The University of Tokyo |
Principal Investigator |
TAKEDA NORIHIKO 東京大学, 医学部附属病院, 特任講師 (40422307)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 炎症 / 低酸素シグナル / 血管リモデリング / マクロファージ / 動脈硬化 / 血管新生 |
Outline of Final Research Achievements |
Vascular remodeling develops during the pathogenesis of atherisclerosis, aortic aneurysm and tumor progression. While the vascular integrity critically influence the progression of these disorders, its underlying mechanisms are still unclear. Macrophages are key mediators of inflammation, and can be broadly classified as M1 (pro-inflammatory) and M2 (anti-inflammatory) type. In this study, we examined the molecular link how macrophage poralization affect the vascular remodeling processes, and elucidated that persistent accumulation of pro-inflammatory macrophages elicits the immature vessel formation. These results showed that not only regulating the abundance of angiogenic factor, but also modulating the behavior of inflammatory cells could be a potential therapeutic target in normalization of the vascular remodeling processes.
|
Report
(4 results)
Research Products
(6 results)
-
[Journal Article] 1. HIF isoforms in the skin differentially regulate systemic arterial pressure.2013
Author(s)
Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.
-
Journal Title
Proc Natl Acad Sci U S A
Volume: 110
Pages: 17570-17575
Related Report
Peer Reviewed
-
[Journal Article] 2. VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.2013
Author(s)
Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
-
Journal Title
FEBS Lett.
Volume: 587
Pages: 2179-2185
Related Report
Peer Reviewed
-
-
-
-