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The roles of macrophage polarization in vascular remodeling

Research Project

Project/Area Number 24591109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

TAKEDA NORIHIKO  東京大学, 医学部附属病院, 特任講師 (40422307)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords炎症 / 低酸素シグナル / 血管リモデリング / マクロファージ / 動脈硬化 / 血管新生
Outline of Final Research Achievements

Vascular remodeling develops during the pathogenesis of atherisclerosis, aortic aneurysm and tumor progression. While the vascular integrity critically influence the progression of these disorders, its underlying mechanisms are still unclear.
Macrophages are key mediators of inflammation, and can be broadly classified as M1 (pro-inflammatory) and M2 (anti-inflammatory) type. In this study, we examined the molecular link how macrophage poralization affect the vascular remodeling processes, and elucidated that persistent accumulation of pro-inflammatory macrophages elicits the immature vessel formation. These results showed that not only regulating the abundance of angiogenic factor, but also modulating the behavior of inflammatory cells could be a potential therapeutic target in normalization of the vascular remodeling processes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] 1. HIF isoforms in the skin differentially regulate systemic arterial pressure.2013

    • Author(s)
      Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Pages: 17570-17575

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2. VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.2013

    • Author(s)
      Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
    • Journal Title

      FEBS Lett.

      Volume: 587 Pages: 2179-2185

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014

    • Author(s)
      仙波宏章、武田憲彦、砂河孝行、杉浦悠毅、安部元、相馬桂、小山雄広、和氣正樹、真鍋一郎、永井良三、小室一成
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生活習慣病、心血管リモデリングにおける低酸素ストレスの役割2013

    • Author(s)
      武田憲彦
    • Organizer
      日本肥満学会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Roles of macrophage hypoxia signaling in cardiac remodeling2013

    • Author(s)
      Hajime Abe, Norihiko Takeda, Hiroaki Semba, Katsura Soma, Takayuki Isagawa, Ichiro Manabe, Ryozo Nagai, Issei Komuro
    • Organizer
      Keystone Symposium 2013
    • Place of Presentation
      Keystone, 米国
    • Related Report
      2012 Research-status Report
  • [Presentation] Hypoxic responses of M1 macrophages are critical for the regulation of cardiac fibrosis2012

    • Author(s)
      Hajime Abe, Norihiko Takeda, Hiroaki Semba, Katsura Soma, Takayuki Isagawa, Ichiro Manabe, Ryozo Nagai, Issei Komuro
    • Organizer
      AHA Scientific Session 2012
    • Place of Presentation
      Los Angeles, 米国
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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