| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We investigated the effects of oral treatment of materials that affect the intestinal immunity or change the gut bacterial flora using the atherosclerosis animal models. Antibiotics against gram-negative bacteria (Neomycin) treatment reduced the atherosclerotic lesion formation in mice, whereas antibiotics against gram-positive bacteria (Vancomycin) treatment had no effect. Now the mechanisms of the experimental results are under investigation. Based on the animal experiments, we examined the association between the incidence of coronary artery diseases (CAD) and the gut bacterial flora types. Compared with normal healthy control person, the content of order Lactobacillales was significantly increased and that of phylum Bacteroidetes was decreased in CAD patients. Further analyses should be needed to attain the therapeutic intervention to gut bacterial flora for prevention of atherosclerotic CAD.
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