Development of novel therapy for prevention of atherosclerosis via modulating gut bacterial flora and intestinal immunity
| Project/Area Number |
24591114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Naoto 神戸大学, 大学院医学研究科, 助教 (00514746)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 動脈硬化 / 腸内細菌 / 腸管免疫 / 制御性T細胞 / 免疫寛容性樹状細胞 / 腸内細菌叢 / 冠動脈疾患 / プロバイオティクス / 腸内細菌細菌叢 / プロバイオティックス |
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| Outline of Final Research Achievements |
We investigated the effects of oral treatment of materials that affect the intestinal immunity or change the gut bacterial flora using the atherosclerosis animal models. Antibiotics against gram-negative bacteria (Neomycin) treatment reduced the atherosclerotic lesion formation in mice, whereas antibiotics against gram-positive bacteria (Vancomycin) treatment had no effect. Now the mechanisms of the experimental results are under investigation. Based on the animal experiments, we examined the association between the incidence of coronary artery diseases (CAD) and the gut bacterial flora types. Compared with normal healthy control person, the content of order Lactobacillales was significantly increased and that of phylum Bacteroidetes was decreased in CAD patients. Further analyses should be needed to attain the therapeutic intervention to gut bacterial flora for prevention of atherosclerotic CAD.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice.2015
Author(s)
Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T, Hirata K.
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Journal Title
Hypertension
Volume: 65
Pages: 889-895
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 腸内細菌と動脈硬化2014
Author(s)
山下智也、佐々木直人、平田健一
Organizer
第46回日本動脈硬化学会総会
Place of Presentation
京王プラザホテル（東京）
Year and Date
2014-07-10 – 2014-07-11
Related Report
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[Presentation] 腸から動脈硬化を予防する2014
Author(s)
山下智也、平田健一
Organizer
第56回日本老年医学会学術集会
Place of Presentation
福岡国際会議場（福岡）
Year and Date
2014-06-12 – 2014-06-14
Related Report
Invited
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[Presentation] In vivo Expansion of Regulatory T Cells Attenuates Aortic Aneurysm Formation in Angiotensin II- Infused Apolipoprotein E-deficient Mice.2013
Author(s)
Keiko Yodoi, Naoto Sasaki, Taiji Mizoguchi, Takuya Matsumoto, Takuo Emoto, Yoshihiro Sasaki, Kazuyuki Kasahara, Tomoyuki Kita, Tomoya Yamashita, Ken-ichi
Organizer
Scientific Session of American Heart Association
Place of Presentation
Dallas, Texas, USA
Related Report
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