| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
O-linked N-acetyl-glucosamine (O-GlcNAc) modification was suggested to have anti-inflammatory effects of reducing M1 phenotype activation via inhibition of NF-κB transcriptional activity in cultured macrophages (Mφ), whereas augmentation of O-GlcNAc modification had no significant effects on atherosclerotic lesions of apoE deficient mice fed with Western diet. Because this apoE deficient mouse model shows hyperlipidemia and hyperglycemia and the anti-inflammatory effects of O-GlcNAc modification were blunted in high-glucose condition in cultured macrophages, O-GlcNAc modification is suggested to complexly regulate macrophage functions and mediate both anti-inflammatory and pro-inflammatory effects in the pathogenesis of atherosclerosis.
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