| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
Maternal obesity elicits metabolic disorders of offspring via epigenetic remodeling of visceral adipose tissue; however, its effect on atherogenesis remains undefined. Here we examined phenotypic alterations in offspring adipose tissue by maternal high-fat diet and investigated their roles in atherosclerosis development. Maternal high-fat diet accelerated atherosclerosis development in adult offspring, in which thoracic periaortic adipose tissue-specific exaggerated accumulation of macrophages and subsequent increase in proinflammatory cytokines expression were involved substantially. Thoracic periaortic adipose tissue specific increased expression of macrophage colony stimulating factor during early development is likely to initiate an inflammatory response by promoting the migration or differentiation/proliferation of monocytes. These data provide a unique opportunity to develop the therapeutic strategy in the prevention of atherosclerotic cardiovascular disease.
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