| Project/Area Number |
24591123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Takao 琉球大学, 医学部, 教授 (70185271)
MIURA Shinichiro 福岡大学, 医学部, 准教授 (20343709)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ApoA-I模倣ペプチド / HDL / コレステロール逆転送系 / アポA-I模倣ペプチド / efflux study / イメージング / pre beta-HDL / 抗動脈硬化作用 / 動脈硬化 / ApoA-I / 分子イメージング / Apo-Eノックアウトマウス / アポA-I |
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| Outline of Final Research Achievements |
We had developed apolipoprotein A-I mimetic peptide (Fukuoka University ApoA-I Mimetic Peptide, FAMP).In this project,we established new diagnostic and therapeutic strategies for atherosclerosis using FAMP.First,FAMP had an anti-atherosclerotic effect through the enhancement of function of HDL in mice model of atherosclerosis.Second,as the mechanisms of FAMP-indiced atheroprotective effects,we found that the administration of FAMP promoted ATP-binding cassette transporter A1-dependent efflux ex vivo,HDL turnover in vivo, and macrophage reverse cholesterol transport in vivo despite reduced plasma HDL-C levels.In addition, HDL with FAMP evoked pleiotropic effects,such as improvement of cardiac function in a model of myocardial ischemia reperfusion injury, an induction of endothelial cell tube formation and anti-inflammation. Finally, using FAMP as a diagnostic tool, FAMP with 68Ga-DOTA is a promising candidate diagnostic tracer for PET imaging of the atherosclerotic lipid burden.
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