New diagnostic and therapeutic strategies for atherosclerosis using newly developed apolipoprotein A-I mimetic peptide
Project/Area Number |
24591123
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Fukuoka University |
Principal Investigator |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
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Co-Investigator(Kenkyū-buntansha) |
OHTA Takao 琉球大学, 医学部, 教授 (70185271)
MIURA Shinichiro 福岡大学, 医学部, 准教授 (20343709)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ApoA-I模倣ペプチド / HDL / コレステロール逆転送系 / アポA-I模倣ペプチド / efflux study / イメージング / pre beta-HDL / 抗動脈硬化作用 / 動脈硬化 / ApoA-I / 分子イメージング / Apo-Eノックアウトマウス / アポA-I |
Outline of Final Research Achievements |
We had developed apolipoprotein A-I mimetic peptide (Fukuoka University ApoA-I Mimetic Peptide, FAMP).In this project,we established new diagnostic and therapeutic strategies for atherosclerosis using FAMP.First,FAMP had an anti-atherosclerotic effect through the enhancement of function of HDL in mice model of atherosclerosis.Second,as the mechanisms of FAMP-indiced atheroprotective effects,we found that the administration of FAMP promoted ATP-binding cassette transporter A1-dependent efflux ex vivo,HDL turnover in vivo, and macrophage reverse cholesterol transport in vivo despite reduced plasma HDL-C levels.In addition, HDL with FAMP evoked pleiotropic effects,such as improvement of cardiac function in a model of myocardial ischemia reperfusion injury, an induction of endothelial cell tube formation and anti-inflammation. Finally, using FAMP as a diagnostic tool, FAMP with 68Ga-DOTA is a promising candidate diagnostic tracer for PET imaging of the atherosclerotic lipid burden.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Newly developed apolipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo.2015
Author(s)
3.Shimizu T*, Tanigawa H*, Miura S, Kuwano T, Takata K, Suematsu Y, Imaizumi S, Yahiro E, Zhang B, Uehara Y, Saku K.
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Journal Title
Int J Cardiol.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] FAMP, a novel apoA-I mimetic peptide, suppresses aortic plaque formation through promotion of biological HDL function in ApoE-deficient mice.2013
Author(s)
Uehara, Y., S. Ando, E. Yahiro, K. Oniki, M. Ayaori, S. Abe, E. Kawachi, B. Zhang, S. Shioi, H. Tanigawa, S. Imaizumi, S. Miura, and K. Saku.
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Journal Title
J Am Heart Assoc
Volume: 2
Issue: 3
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel Molecular Imaging of Atherosclerosis With Gallium-68-Labeled Apolipoprotein A-I Mimetic Peptide and Positron Emission Tomography.2013
Author(s)
Kawachi E, Uehara Y, Hasegawa K, Yahiro E, Ando S, Wada Y, Yano T, Nishikawa H, Shiomi M, Miura SI, Watanabe Y, Saku K.
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Journal Title
NAID
Related Report
Peer Reviewed
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