| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The objective of this is study was to elucidate the pathophysiological mechanisms of chronic obstructive pulmonary disease. It has been reported that the apoptosis of lung structure maintenance cells causes emphysema.
Our hypothesis was mTOR inhibition may reduce lung cell proliferation and induce emphysematous changes in rat lung. We administered sirolimus, a mTOR inhibitor, to rat and investigated the rat lungs. Sirolimus induced rat lungs revealed that alveolar enlargement and lung cell apoptosis due to the reduction of VEGF and phosphor Akt expression.
The mTOR signal may important to maintain the lung structure cell maintenance.
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