Investigation of the pathophysiological mechanisms of chronic obstructive pulmonary disease by the inhibition of mTOR-related cell prolifelative signal
| Project/Area Number |
24591127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
YASUO Masanori 信州大学, 学術研究院医学系(医学部附属病院), 講師 (20402117)
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| Co-Investigator(Kenkyū-buntansha) |
HANAOKA Masayuki 信州大学, 学術研究院医学系, 教授 (20334899)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺気腫 / 動物モデル / アポトーシス / mTOR阻害薬 / 炎症 / 慢性閉塞性肺疾患 / 病因 |
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| Outline of Final Research Achievements |
The objective of this is study was to elucidate the pathophysiological mechanisms of chronic obstructive pulmonary disease. It has been reported that the apoptosis of lung structure maintenance cells causes emphysema.
Our hypothesis was mTOR inhibition may reduce lung cell proliferation and induce emphysematous changes in rat lung. We administered sirolimus, a mTOR inhibitor, to rat and investigated the rat lungs. Sirolimus induced rat lungs revealed that alveolar enlargement and lung cell apoptosis due to the reduction of VEGF and phosphor Akt expression.
The mTOR signal may important to maintain the lung structure cell maintenance.
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Report
(5 results)
Research Products
(1 results)
