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Role of adiponectin in COPD

Research Project

Project/Area Number 24591129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

TAKEDA Yoshito  大阪大学, 医学(系)研究科(研究院), 助教 (40452388)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアディポネクチン / COPD / CT / 超編極ガスXe-MRI / COPD / イメージング / imaging / adiponectin
Outline of Final Research Achievements

COPD is predicted to become the third commonest cause of death worldwide by 2020. It is important to clarify mechanisms involved in COPD and explore drugs to treat this systemic disease. Given that hypoadiponectinemia could be an underlying mechanism for COPD and the key link between COPD and various comorbidities, to further test the phenotype of APN KO mice, examined its underlying mechanism and its potential use of therapy is significant. Using mouse model, we evaluated the availability of hyperpolarized 129Xe MRI and micro- CT compared with traditional methods, such as plethysmography and histology in murine model.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] 8.Efficacy and Safety of Pirfenidone for Idiopathic Pulmonary Fibrosis.2014

    • Author(s)
      Takeda Y, Tsujino K, Kijima T, Kumanogoh A
    • Journal Title

      Patient Prefer Adherence.

      Volume: 21 Pages: 361-370

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 6.Development of microscopic polyangiitis-related pulmonary fibrosis in a patient with autoimmune pulmonary alveolar proteinosis.2014

    • Author(s)
      Kinehara Y, Kida H, Inoue Y, Hirose M, Nakabayashi A, Takeuchi Y, Hayama Y, Fukushima K, Hirata H, Inoue K, Minami T, Nagatomo I, Takeda Y, Funakoshi T, Kijima T, Kumanogoh A.
    • Journal Title

      BMC Pulm Med.

      Volume: 4 Pages: 172-172

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 7.A Retrospective Study of Prognostic Factors in Patients with Interstitial Pneumonia Receiving Long-Term Oxygen Therapy.2014

    • Author(s)
      Higashiguchi M, Kijima T, Sumikawa H, Honda O, Minami T, Hirata H, Inoue K, Nagatomo I, Takeda Y, Kida H, Tomiyama N, Kumanogoh A.
    • Journal Title

      Lung

      Volume: 5 Pages: 210-214

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD92013

    • Author(s)
      (2) He P, Kuhara H, Tachibana I, Jin Y, Takeda Y, Tetsumoto S, Minami T, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Naka T, Morii E, Kawase I, Kumanogoh A
    • Journal Title

      FEBS Open Bio.

      Volume: 10 Pages: 225-230

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of noninvasive morphological and diffusion imaging in mouse emphysema by micro-computed tomography and hyperpolarized (129)Xe magnetic resonance imaging.2013

    • Author(s)
      (11) Tetsumoto S, Takeda Y, Imai H, Kimura A, Jin Y, Nakanishi K, Maeda Y, Kuhara H, Tsujino K, Iwasaki T, Shigeta H, Kondo Y, Ito M, Minami T, Hirata H, Takahashi R, Kohmo S, Nagatomo I, Inoue K, Kida H, Kijima T, Tachibana I, Maeda N, Funahashi T, Shimomura I, Fujiwara H, Kumanogoh A.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 49 Pages: 592-600

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Statins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages.2013

    • Author(s)
      (9) Jin Y, Tachibana I, Takeda Y, He P, Kang S, Suzuki M, Kuhara H, Tetsumoto S, Tsujino K, Minami T, Iwasaki T, Nakanishi K, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Ito M, Saya H, Kumanogoh A.
    • Journal Title

      PLoS One

      Volume: 9 Pages: 737-746

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deletion of Tetraspanin CD9 Diminishes Lymphangiogenesis in Vivo and in Vitro.2013

    • Author(s)
      (10) Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A.
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 2118-2131

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.2013

    • Author(s)
      (8) Minami T, Kijima T, Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata H, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A.
    • Journal Title

      Sci Rep.

      Volume: 3 Pages: 2669-2669

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. J Biol Chem.2013

    • Author(s)
      Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K
    • Journal Title

      J Biol Chem.

      Volume: 288 Pages: 2118-2131

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Novel Link Between Adipocytes and COPD2012

    • Author(s)
      Takeda Y, Nakanishi K, Tachibana I, Kumanogoh A
    • Journal Title

      Vitam Horm

      Volume: 90 Pages: 419-435

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity.2012

    • Author(s)
      Tsujino K, Takeda Y, Arai T, Shintani Y
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 186 Pages: 170-180

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis.2012

    • Author(s)
      Ihara S, Kida H, Arase H, Tripathi LP, Chen YA, Kimura T
    • Journal Title

      Cancer Res.

      Volume: 72 Pages: 2990-2999

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] アディポネクチンとCOPD2012

    • Author(s)
      武田吉人
    • Journal Title

      分子呼吸器病

      Volume: 16 Pages: 16-20

    • Related Report
      2012 Research-status Report
  • [Journal Article] アディポネクチンとCOPD2012

    • Author(s)
      中西香織,武田吉人
    • Journal Title

      Angiology Frontier

      Volume: 11 Pages: 48-56

    • Related Report
      2012 Research-status Report
  • [Journal Article] HER2 as therapeutic target for overcoming ATP-Binding cassette transporter-mediated chemoresistance in small cell lung cancer.2012

    • Author(s)
      Minami T, Kijima T, Otani Y, Kohmo S, Takahashi R, Nagatomo I, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogho A
    • Journal Title

      Mol Cancer Ther

      Volume: 11 Pages: 830-841

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 肺の生活習慣病:COPDにおける慢性炎症2014

    • Author(s)
      武田吉人
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tetraspanins CD9 and CD81 Double-Knockout mice spontaneously develop not only COPD-like phenotype, but also multiple aging phenotypes.2014

    • Author(s)
      武田吉人,近藤 康、金 英姫,立花 功,木島貴志,熊ノ郷 淳
    • Organizer
      American Thoracic Society International Conference 2014
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] COPDにおけるエクソソーム:慢性炎症の視点から2014

    • Author(s)
      武田吉人
    • Organizer
      第54回 日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Double deletion of tetraspanins CD9 and CD81 in mice causes not only COPD-like phenotypte, but also a syndrome resembling aging2014

    • Author(s)
      武田吉人、金 英姫,長友 泉
    • Organizer
      第54回 日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肺胞上皮細胞のintegrityを担うテトラスパニンCD1512013

    • Author(s)
      武田吉人
    • Organizer
      第53回 日本呼吸器学会学術講演会シンポジウム
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] テトラスパニンCD9/CD81はSIRT 1の制御によりアンチエイジング作用を示す2013

    • Author(s)
      武田吉人,金 英姫,井上幸治,木田 博,木島貴志,伊藤真里,立花 功,熊ノ郷 淳
    • Organizer
      第53回 日本呼吸器学会学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 超偏極 129 Xe MRIによる新たなマウス気腫評価法の確立2013

    • Author(s)
      鉄本訓史,武田吉人,金 英姫,中西香織,前田陽平,井上幸治,長友 泉,木田 博,
    • Organizer
      第53回 日本呼吸器学会学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Double deletion of tetraspanins CD9 and CD81 in mice spontaneously develops not only COPD-like phenotype, but also multiple aging phenotypes.2013

    • Author(s)
      武田吉人,金 英姫,辻野和之,立花 功,熊ノ郷 淳
    • Organizer
      American Thoracic Society International Conference 2013
    • Place of Presentation
      フィラデルフィア(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新たな老化モデルとしてのテトラスパニンCD9/CD81二重欠損マウス2013

    • Author(s)
      武田吉人,金 英姫,立花 功,杉本 研,楽木宏実,熊ノ郷 淳
    • Organizer
      第55回 日本老年医学会学術集会総会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Research-status Report
  • [Presentation] 新たな老化モデルとしてのテトラスパニンCD9/CD81二重欠損マウス2013

    • Author(s)
      武田吉人,近藤 康,金 英姫,立花 功,杉本 研,楽木宏実,熊ノ郷 淳
    • Organizer
      第36回日本分子生物学会総会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Research-status Report
  • [Presentation] 超偏極129XeMRIによる新たなマウス肺気腫評価法確立2013

    • Author(s)
      鉄本訓史 武田吉人 金、中西、前田 井上幸治 長友泉 木田博 木島貴志 立花功 熊ノ郷 淳
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺胞上皮細胞のintegrityを担うテトラスパニンCD1512013

    • Author(s)
      武田吉人
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Validation of non-invasive morphological and diffusion imaging in mouse emphysema by micro-CT and hyperpolarized 129Xe MRI2013

    • Author(s)
      Satoshi Tetsumoto, Yoshito Takeda
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      フィラデルフィア
    • Related Report
      2012 Research-status Report
  • [Presentation] テトラスパニンCD9/CD81二重欠損マウスはCOPDモデル? それとも老化モデル?2012

    • Author(s)
      武田吉人,金 英姫,立花 功,熊ノ郷 淳.
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Deletion of tetraspanin CD151 in mice spontaneously leads to pulmonary fibrosis with age through epithelial disintegrity.2012

    • Author(s)
      Takeda Y, Tsujino K, Tachibana I, Kumanogoh A.
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Research-status Report
  • [Presentation] Double deletion of CD9 and CD81 in mice leads to a syndrome resembling aging.2012

    • Author(s)
      Takeda Y, Jin Y, Tachibana I, Kumanogoh A.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Book] Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis.2014

    • Author(s)
      Takeda Y, Tsujino K, Kijima T, Kumanogoh A.
    • Total Pages
      8
    • Publisher
      Patient Preference and Adherence
    • Related Report
      2013 Research-status Report
  • [Remarks] アディポネクチンと呼吸器疾患

    • URL

      http://www.nihonbashi-medical.jpn.org/ou_imed3lab8/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 大阪大学 呼吸器内科ホームページ アディポネクチンとCOPD

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed/lab_8/index.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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