Role of adiponectin in COPD
Project/Area Number |
24591129
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Osaka University |
Principal Investigator |
TAKEDA Yoshito 大阪大学, 医学(系)研究科(研究院), 助教 (40452388)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アディポネクチン / COPD / CT / 超編極ガスXe-MRI / COPD / イメージング / imaging / adiponectin |
Outline of Final Research Achievements |
COPD is predicted to become the third commonest cause of death worldwide by 2020. It is important to clarify mechanisms involved in COPD and explore drugs to treat this systemic disease. Given that hypoadiponectinemia could be an underlying mechanism for COPD and the key link between COPD and various comorbidities, to further test the phenotype of APN KO mice, examined its underlying mechanism and its potential use of therapy is significant. Using mouse model, we evaluated the availability of hyperpolarized 129Xe MRI and micro- CT compared with traditional methods, such as plethysmography and histology in murine model.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] 6.Development of microscopic polyangiitis-related pulmonary fibrosis in a patient with autoimmune pulmonary alveolar proteinosis.2014
Author(s)
Kinehara Y, Kida H, Inoue Y, Hirose M, Nakabayashi A, Takeuchi Y, Hayama Y, Fukushima K, Hirata H, Inoue K, Minami T, Nagatomo I, Takeda Y, Funakoshi T, Kijima T, Kumanogoh A.
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Journal Title
BMC Pulm Med.
Volume: 4
Pages: 172-172
Related Report
Peer Reviewed / Open Access
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[Journal Article] 7.A Retrospective Study of Prognostic Factors in Patients with Interstitial Pneumonia Receiving Long-Term Oxygen Therapy.2014
Author(s)
Higashiguchi M, Kijima T, Sumikawa H, Honda O, Minami T, Hirata H, Inoue K, Nagatomo I, Takeda Y, Kida H, Tomiyama N, Kumanogoh A.
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Journal Title
Lung
Volume: 5
Pages: 210-214
Related Report
Peer Reviewed / Open Access
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[Journal Article] Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD92013
Author(s)
(2) He P, Kuhara H, Tachibana I, Jin Y, Takeda Y, Tetsumoto S, Minami T, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Naka T, Morii E, Kawase I, Kumanogoh A
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Journal Title
FEBS Open Bio.
Volume: 10
Pages: 225-230
Related Report
Peer Reviewed
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[Journal Article] Validation of noninvasive morphological and diffusion imaging in mouse emphysema by micro-computed tomography and hyperpolarized (129)Xe magnetic resonance imaging.2013
Author(s)
(11) Tetsumoto S, Takeda Y, Imai H, Kimura A, Jin Y, Nakanishi K, Maeda Y, Kuhara H, Tsujino K, Iwasaki T, Shigeta H, Kondo Y, Ito M, Minami T, Hirata H, Takahashi R, Kohmo S, Nagatomo I, Inoue K, Kida H, Kijima T, Tachibana I, Maeda N, Funahashi T, Shimomura I, Fujiwara H, Kumanogoh A.
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Journal Title
Am J Respir Cell Mol Biol
Volume: 49
Pages: 592-600
Related Report
Peer Reviewed
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[Journal Article] Statins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages.2013
Author(s)
(9) Jin Y, Tachibana I, Takeda Y, He P, Kang S, Suzuki M, Kuhara H, Tetsumoto S, Tsujino K, Minami T, Iwasaki T, Nakanishi K, Kohmo S, Hirata H, Takahashi R, Inoue K, Nagatomo I, Kida H, Kijima T, Ito M, Saya H, Kumanogoh A.
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Journal Title
PLoS One
Volume: 9
Pages: 737-746
Related Report
Peer Reviewed
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[Journal Article] Deletion of Tetraspanin CD9 Diminishes Lymphangiogenesis in Vivo and in Vitro.2013
Author(s)
(10) Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A.
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Journal Title
J Biol Chem
Volume: 288
Pages: 2118-2131
Related Report
Peer Reviewed
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[Journal Article] Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.2013
Author(s)
(8) Minami T, Kijima T, Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata H, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A.
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Journal Title
Sci Rep.
Volume: 3
Pages: 2669-2669
Related Report
Peer Reviewed
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[Journal Article] HER2 as therapeutic target for overcoming ATP-Binding cassette transporter-mediated chemoresistance in small cell lung cancer.2012
Author(s)
Minami T, Kijima T, Otani Y, Kohmo S, Takahashi R, Nagatomo I, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogho A
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Journal Title
Mol Cancer Ther
Volume: 11
Pages: 830-841
Related Report
Peer Reviewed
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