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Role of sphingolipids in the respiratory immune system

Research Project

Project/Area Number 24591131
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKobe University

Principal Investigator

NISHIMURA Yoshihiro  神戸大学, 医学部附属病院, 教授 (20291453)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Kazuyuki  神戸大学, 大学院医学研究科, 講師 (50403275)
OKADA Taro  神戸大学, 大学院医学研究科, 准教授 (80304088)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsスフィンゴシン1リン酸 / スフィンゴシン1リン酸受容体 / 喘息 / JTE013 / TSLP / IL-25 / IL-33 / 気管支喘息 / 樹状細胞 / 卵白アルブミン / マウス / 国際情報交換 / 気道炎症 / 気道リモデリング / 治療
Outline of Final Research Achievements

Sphingosine kinase phosphorylates sphingosine to generate sphingosine 1 phosphate (S1P). S1P stimulates the five S1P receptors (S1PR), but S1PRs’ roles in the respiratory system and the therapeutic effect of S1PR antagonist in experimental asthma mouse model are not well understood. Bronchial epithelial cells in mouse lung expressed S1PR1 to 3. S1P induced proinflammatory cytokine production by the bronchial epithelial cells. In experimental asthma model, JTE013 exhibited substantially attenuated eosinophilic inflammation. In conclusion, JTE013 attenuated eosinophilic inflammation via regulating proinflammatory cytokines from bronchial epithelial cells. Our results suggest that JTE013 might be a possible candidate for the bronchial asthma treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Phospholipase Cε, an effector of Ras and Rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.2014

    • Author(s)
      Tatsuya Nagano, Hironori Edamatsu, Kazuyuki Kobayashi, Nobuyuki Takenaka, Masatsugu Yamamoto, Naoto Sasaki, Yoshihiro Nishimura, Tohru Kataoka
    • Journal Title

      PLOS ONE

      Volume: 9巻 Issue: 9 Pages: e108373-e108373

    • DOI

      10.1371/journal.pone.0108373

    • NAID

      120005603833

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] スフィンゴシン1リン酸受容体2型の肥満細胞の分化、樹状細胞の遊走能における役割2015

    • Author(s)
      寺下智美、永野達也、河良崇、徳永俊太郎、國政啓、小林和幸、西村善博
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京、東京国際フォーラム
    • Year and Date
      2015-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] rucial role of cell-mediated airway inflammation in mice2014

    • Author(s)
      Tatsuya Nagano、Hironori Edamatsu、Kazuyuki Kobayashi、Yoshihiro Nishimura、Tohru Kataoka
    • Organizer
      ATS2014
    • Place of Presentation
      米国、サンディエゴ
    • Year and Date
      2014-05-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] S1P受容体のアゴニスト/アンタゴニスト投与による気管支喘息の表現型の変化に対する検討2014

    • Author(s)
      河良崇、永野達也、田村大介、立原素子、大寺博、小林和幸、船田泰弘、西村善博
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] S1P受容体のアゴニスト/アンタゴニスト投与による気管支喘息の表現型の変化に対する検討2014

    • Author(s)
      河良崇、永野達也、田村大介、立原素子、大寺博、小林和幸、船田泰弘、西村善博
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 喘息モデルマウスにおけるDMSとFTY-720の作用に対する検討2012

    • Author(s)
      河良崇、小林和幸、石川結美子、船田泰弘、小谷義一、西村善博
    • Organizer
      第52回日本呼吸科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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