| Project/Area Number |
24591134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroshi 奈良県立医科大学, 医学部, 教授 (20195374)
YOSHIKAWA Masanori 奈良県立医科大学, 医学部, 准教授 (80271203)
TOMODA Koichi 奈良県立医科大学, 医学部, 講師 (90364059)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 慢性閉塞性肺疾患 / 表現型規定因子 / 日米比較 / 気腫 |
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| Outline of Final Research Achievements |
In chronic obstructive pulmonary disease (COPD) there are two phenotypes; emphysema and chronic bronchitis. In japan most of the patients are emphysema with cachexia while in the West most of those are chronic bronchitis with obese. However it has not been fully elucidated what factors determine the phenotype in COPD.
Autophagy, which is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, is accelerated on starvation. To elucidate the role of autophagy on the phenotype in COPD, we measured the index of autophagy in plasma of Japanese COPD patients and investigated the relationship between the index and emphysema. LC3B, regulator of autophagy, was decreased in smokers compared with healthy non-smokers. The decrease was accelerated in COPD. In patients with severe emphysema the LC3B levels was inversely correlated with emphysema sore.
In conclusion an impaired systemic autophagy can contribute to development and progression of emphysema.
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