Role of innate immunity in the pathophysiology of chronic obstructive pulmonary disease
Project/Area Number |
24591135
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Tohoku University |
Principal Investigator |
KOARAI AKIRA 東北大学, 大学病院, 助教 (80458059)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 慢性閉塞性肺疾患 / 自然免疫 / toll様受容体 / マクロファージ / 気道上皮 / 増悪 / タバコ煙 / 急性増悪 / Toll様受容体 / 酸化ストレス / ウイルス感染 |
Outline of Final Research Achievements |
Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, have a key role in the innate immune system. In the present study, we demonstrated that cigarette smoke, which is involved in the pathogenesis of COPD, augments the expression and responses of TLR3 in human macrophages and airway epithelial cells, and this may contribute to neutrophilic airway inflammation, parenchymal destruction, and mucus hypersecretion in the lungs of smokers and patients with COPD.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells.2015
Author(s)
K. Kanai, A. Koarai, Y.Shishikura, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M.Ichinose.
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Journal Title
Respir Investig.
Volume: in press
Issue: 4
Pages: 137-148
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.2014
Author(s)
Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
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Journal Title
J Immunol
Volume: 192
Issue: 11
Pages: 4977-4988
DOI
Related Report
Peer Reviewed
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[Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells2012
Author(s)
Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
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Journal Title
Respir Res
Volume: 13
Issue: 1
Pages: 63-63
DOI
Related Report
Peer Reviewed
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[Presentation] Cigarette Smoke Augments MUC5AC Mucin Production Via TLR3-EGFR Pathway In Airway Epithelial Cells.2014
Author(s)
K. Kanai, A. Koarai, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M. Ichinose.
Organizer
ATS International Conference 2014
Place of Presentation
San Diego Convention Center (San Diego, USA)
Year and Date
2014-05-17 – 2014-05-21
Related Report
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[Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells.
Author(s)
Kuninobu Kanai, Akira Koarai, Hisatoshi Sugiura, Tomohiro Ichikawa, Takashi Kikuchi, Keiichiro Akamatsu, Tsunahiko Hirano, Masanori Nakanishi, Kazuto Matsunaga, Yoshiaki Minakata and Masakazu Ichinose.
Organizer
ERS annual congress 2013
Place of Presentation
Barcelona, Spain
Related Report
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