| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, have a key role in the innate immune system. In the present study, we demonstrated that cigarette smoke, which is involved in the pathogenesis of COPD, augments the expression and responses of TLR3 in human macrophages and airway epithelial cells, and this may contribute to neutrophilic airway inflammation, parenchymal destruction, and mucus hypersecretion in the lungs of smokers and patients with COPD.
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