The development of personalized treatment for patients with COPD
Project/Area Number |
24591136
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Wakayama Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 身体活動性 / COPD / 加速度計 / physical activity / accelerometer |
Outline of Final Research Achievements |
We developed an evaluation method for the physical activity of patients with COPD by using a triaxial accelerometer, Actimarker, which is available in Japan. The duration of physical activity in patients with COPD was significantly reduced at any intensity of activity, and that at greater than or equal to 3.0METs was reduced by 50% compared to that of age-matched healthy subjects. Transdermal tulobuterol, a beta-2 adrenergic agonist, could improve the physical activity, especially at high intensity. There is a flying disc accuracy game with low intensity of activity that is feasible for patients and sufficiently enjoyable that they were motivated to participate repeatedly. Participation in such a game might be an effective intervention to maintain or improve the physical activity of patients with COPD.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Ongoing Allergic Rhinitis Impairs Asthma Control by Enhancing the Lower Airway Inflammation2014
Author(s)
Oka A, Matsunaga K, Kamei T, Sakamoto Y, Hirano T, Hayata A, Akamatsu K, Kikuchi T, Hiramatsu M, Ichikawa T, Nakanishi M, Minakata Y, Yamamoto N
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Journal Title
J Allergy Clin Immunol Pract
Volume: 2
Issue: 2
Pages: 172-178
DOI
Related Report
Peer Reviewed
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[Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.2014
Author(s)
Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
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Journal Title
J Immunol
Volume: 192
Issue: 11
Pages: 4977-4988
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced level of physical activity in Japanese patients with chronic obstructive pulmonary disease2014
Author(s)
Minakata Y, Sugino A, Kanda M, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, Sugiura H, Matsunaga K, Ichinose M
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Journal Title
Respiratory investigation
Volume: 52
Issue: 1
Pages: 41-48
DOI
Related Report
Peer Reviewed
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[Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27-hydroxycholesterol in tissue fibrosis2012
Author(s)
Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Yanagisawa S, Furukawa K, Kawabata H, Ichinose M
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Journal Title
Chest
Volume: 142
Issue: 2
Pages: 329-337
DOI
Related Report
Peer Reviewed
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[Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells2012
Author(s)
Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
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Journal Title
Respir Res
Volume: 13
Issue: 1
Pages: 63-63
DOI
Related Report
Peer Reviewed
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[Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics2012
Author(s)
Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M
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Journal Title
Clin Exp Allergy
Volume: 42
Pages: 775-781
Related Report
Peer Reviewed
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[Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells2014
Author(s)
Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, and Ichinose M
Organizer
2014 ATS International Conference
Place of Presentation
San Diego, USA
Year and Date
2014-05-22
Related Report
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[Presentation] Changes in forced expiratiry volume in 1 second over time in patients with controlled asthma at baseline2014
Author(s)
Matsunaga K, Ichikawa T, Oka A, Morishita Y, Kanai K, Hiramatsu M, Akamatsu H, Kawabata H, Kikuchi T, Akamatsu K, Hirano T, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
Organizer
第54回日本呼吸器学会学術講演会
Place of Presentation
大阪市
Year and Date
2014-04-25 – 2014-04-27
Related Report
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[Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells2013
Author(s)
Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
Organizer
2013 ERS Annual Congress
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Evaluation of intensity-based physical activity in patients with COPD2012
Author(s)
Minakata Y, Sugino A, Honda Y, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, Sugiura H, Matsunaga K, Ichinose M
Organizer
2012 ATS International Conference
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] 25-hydroxycholesterol enhances interferon release after Toll-like receptor 3 stimulation in human airway epithelial cells2012
Author(s)
2. Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
Organizer
2012 ATS International Conference
Place of Presentation
San Francisco, USA
Related Report
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