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The development of personalized treatment for patients with COPD

Research Project

Project/Area Number 24591136
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionWakayama Medical University

Principal Investigator

MINAKATA YOSHIAKI  和歌山県立医科大学, 医学部, 博士研究員 (80295815)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords身体活動性 / COPD / 加速度計 / physical activity / accelerometer
Outline of Final Research Achievements

We developed an evaluation method for the physical activity of patients with COPD by using a triaxial accelerometer, Actimarker, which is available in Japan. The duration of physical activity in patients with COPD was significantly reduced at any intensity of activity, and that at greater than or equal to 3.0METs was reduced by 50% compared to that of age-matched healthy subjects. Transdermal tulobuterol, a beta-2 adrenergic agonist, could improve the physical activity, especially at high intensity. There is a flying disc accuracy game with low intensity of activity that is feasible for patients and sufficiently enjoyable that they were motivated to participate repeatedly. Participation in such a game might be an effective intervention to maintain or improve the physical activity of patients with COPD.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (63 results)

All 2015 2014 2013 2012

All Journal Article (31 results) (of which Peer Reviewed: 23 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (25 results) (of which Invited: 11 results) Book (7 results)

  • [Journal Article] COPDの身体活動性をめぐるサイエンス 身体活動性の評価法2015

    • Author(s)
      南方良章
    • Journal Title

      日本呼吸器学会雑誌

      Volume: 4 Pages: 8-14

    • Related Report
      2014 Annual Research Report
  • [Journal Article] COPD病態理解の変遷と治療の新展開 COPDによる身体活動性低下2015

    • Author(s)
      南方良章
    • Journal Title

      Progress in Medicine

      Volume: 35 Pages: 219-222

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 新薬の最近の話題 ウメクリジニウム/ビランテロール配合薬2015

    • Author(s)
      南方良章
    • Journal Title

      分子呼吸器病

      Volume: 19 Pages: 79-82

    • NAID

      40021332526

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Feasibility of flying disc game for patients with oxygen therapy2014

    • Author(s)
      Honda Y, Minakata Y, Morishita Y, Sugino A, Hayata A, Ichikawa T, Nakanishi M, Matsunaga K, Yamamoto N
    • Journal Title

      Clin Res Pulmonol

      Volume: 2 Pages: 1024-1024

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ongoing Allergic Rhinitis Impairs Asthma Control by Enhancing the Lower Airway Inflammation2014

    • Author(s)
      Oka A, Matsunaga K, Kamei T, Sakamoto Y, Hirano T, Hayata A, Akamatsu K, Kikuchi T, Hiramatsu M, Ichikawa T, Nakanishi M, Minakata Y, Yamamoto N
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 2 Issue: 2 Pages: 172-178

    • DOI

      10.1016/j.jaip.2013.09.018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.2014

    • Author(s)
      Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 11 Pages: 4977-4988

    • DOI

      10.4049/jimmunol.1302919

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in forced expiratory volume in 1 second over time in patients with controlled asthma at baseline2014

    • Author(s)
      Kazuto Matsunaga
    • Journal Title

      Respiratory Medicine

      Volume: 108 Issue: 7 Pages: 976-982

    • DOI

      10.1016/j.rmed.2014.04.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人のCOPD患者におけるウメクリジニウム/ビランテロール配合剤(UMEC/VI)の長期投与試験2014

    • Author(s)
      南方良章、早乙女徹、三原加瑞子、橋本賢一
    • Journal Title

      呼吸

      Volume: 33 Pages: 1037-1047

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COPD患者と身体活動性2014

    • Author(s)
      平松政高、南方良章
    • Journal Title

      呼吸と循環

      Volume: 62 Pages: 578-582

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Reduced level of physical activity in Japanese patients with chronic obstructive pulmonary disease2014

    • Author(s)
      Minakata Y, Sugino A, Kanda M, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, Sugiura H, Matsunaga K, Ichinose M
    • Journal Title

      Respiratory investigation

      Volume: 52 Issue: 1 Pages: 41-48

    • DOI

      10.1016/j.resinv.2013.06.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of transdermal tulobuterol patch on the physical activity in eight male subjects with chronic obstructive pulmonary disease2013

    • Author(s)
      Minakata Y, Morishita Y, Hiramatsu M, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Ichinose M
    • Journal Title

      Clinical Research in Pulmonology

      Volume: 1 Pages: 1-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difference in time-course of improvement in asthma control measures between budesonide and budesonide/formoterol2013

    • Author(s)
      Matsunaga K
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 26 Issue: 2 Pages: 189-194

    • DOI

      10.1016/j.pupt.2012.10.006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Persistent elevation of exhaled nitric oxide and modification of corticosteroid therapy in asthma.2013

    • Author(s)
      T. Hirano, H. Sugiura et al.
    • Journal Title

      Respir Invest

      Volume: 51 Issue: 2 Pages: 84-91

    • DOI

      10.1016/j.resinv.2013.01.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway2013

    • Author(s)
      Tomohiro Ichikawa
    • Journal Title

      Experimental Cell Research

      Volume: 319 Issue: 8 Pages: 1176-1186

    • DOI

      10.1016/j.yexcr.2013.02.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictors for Identifying the Efficacy of Systemic Steroids on Sustained Exhaled Nitric Oxide Elevation in Severe Asthma2013

    • Author(s)
      Matsunaga K, Hirano T, Akamatsu K, Minakata Y
    • Journal Title

      Allergology International

      Volume: 62 Issue: 3 Pages: 359-365

    • DOI

      10.2332/allergolint.12-OA-0530

    • NAID

      130004477190

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stratifying a Risk for an Increased Variation of Airway Caliber among the Clinically Stable Asthma2013

    • Author(s)
      Hayata A, Matsunaga K, Hirano T, Akamatsu K, Ichikawa T, Minakata Y, Ichinose M
    • Journal Title

      Allergology International

      Volume: 62 Issue: 3 Pages: 343-349

    • DOI

      10.2332/allergolint.13-OA-0543

    • NAID

      130004477196

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between alveolar nitric oxide concentration in exhaled air and small airway function in COPD.2013

    • Author(s)
      T. Hirano, H. Sugiura et al.
    • Journal Title

      J Breath Res

      Volume: 7 Issue: 4 Pages: 046002-046002

    • DOI

      10.1088/1752-7155/7/4/046002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性閉塞性肺疾患患者の日常活動性とその評価法の確立2013

    • Author(s)
      杉野亮人、南方良章、本多雄一、田島文博、一ノ瀬正和
    • Journal Title

      日本呼吸ケア・リハビリテーション学会誌

      Volume: 22 Pages: 236-241

    • NAID

      130005147843

    • Related Report
      2013 Research-status Report
  • [Journal Article] COPD患者の身体活動性の低下2013

    • Author(s)
      南方良章
    • Journal Title

      Modern Physician

      Volume: 33 Pages: 1368-1371

    • Related Report
      2013 Research-status Report
  • [Journal Article] Validation of the Triaxial Accelerometer for the Evaluation of Physical Activity in Japanese Patients with COPD2012

    • Author(s)
      Kanda M, Minakata Y, Matsunaga K, Sugiura H, Hirano T, Koarai A, Akamatsu K, Ichikawa T, Ichinose M
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 4 Pages: 369-375

    • DOI

      10.2169/internalmedicine.51.6441

    • NAID

      130002062007

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough2012

    • Author(s)
      Takemura M et al.
    • Journal Title

      Respiration

      Volume: 83 Issue: 4 Pages: 308-315

    • DOI

      10.1159/000332835

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Noninvasive Positive Pressure Ventilation in Elderly Patients with Acute Hypercapnic Respiratory Failure2012

    • Author(s)
      Kida Y, Minakata Y, Yamada Y, Ichinose M
    • Journal Title

      Respiration

      Volume: 83 Issue: 5 Pages: 377-382

    • DOI

      10.1159/000328399

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.2012

    • Author(s)
      Sugiura H et al.
    • Journal Title

      Respirology

      Volume: 17 Issue: 3 Pages: 533-540

    • DOI

      10.1111/j.1440-1843.2012.02136.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts.2012

    • Author(s)
      Sugiura H
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302 Issue: 8 Pages: 764-774

    • DOI

      10.1152/ajplung.00342.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27-hydroxycholesterol in tissue fibrosis2012

    • Author(s)
      Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Yanagisawa S, Furukawa K, Kawabata H, Ichinose M
    • Journal Title

      Chest

      Volume: 142 Issue: 2 Pages: 329-337

    • DOI

      10.1378/chest.11-2091

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages.2012

    • Author(s)
      Koarai A
    • Journal Title

      Respirology

      Volume: 17 Issue: 6 Pages: 1018-1025

    • DOI

      10.1111/j.1440-1843.2012.02198.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells2012

    • Author(s)
      Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
    • Journal Title

      Respir Res

      Volume: 13 Issue: 1 Pages: 63-63

    • DOI

      10.1186/1465-9921-13-63

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics2012

    • Author(s)
      Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M
    • Journal Title

      Clin Exp Allergy

      Volume: 42 Pages: 775-781

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 短時間作用型β2刺激薬による慢性閉塞性肺疾患患者の運動耐容能改善効果と改善寄与因子2012

    • Author(s)
      本多雄一, 南方良章, 杉野亮人, 神田匡兄, 松永和人, 田島文博, 一ノ瀬正和
    • Journal Title

      呼吸

      Volume: 31 Pages: 1058-1064

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 全身炎症と併存症―不全を中心に―2012

    • Author(s)
      南方良章, 一ノ瀬正和
    • Journal Title

      呼吸と循環

      Volume: 60 Pages: 1029-1035

    • Related Report
      2012 Research-status Report
  • [Journal Article] COPD患者の日常活動性評価2012

    • Author(s)
      南方良章
    • Journal Title

      呼吸

      Volume: 31 Pages: 977-983

    • Related Report
      2012 Research-status Report
  • [Presentation] COPDのPhysical Activityの評価と治療2014

    • Author(s)
      南方良章
    • Organizer
      大阪COPDフォーラム
    • Place of Presentation
      大阪市
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] COPDに対する身体活動性評価と改善に向けた取り組み2014

    • Author(s)
      南方良章
    • Organizer
      第24回日本呼吸ヶア・リハビリテーション学会学術集会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] COPDにおける運動耐容能と身体活動性2014

    • Author(s)
      南方良章
    • Organizer
      東神戸呼吸器疾患講演会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新ガイドラインに基づくCOPD診療2014

    • Author(s)
      南方良章
    • Organizer
      日本医師会生涯教育協力講座
    • Place of Presentation
      和歌山市
    • Year and Date
      2014-08-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] COPDにおける身体活動性の重要性とその評価2014

    • Author(s)
      南方良章
    • Organizer
      第56回日本老年医学会学術集会・総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Toll-Like Receptor-3 Activation Augments Matrix Metalloproteinases Production Through Reactive Nitrogen Species Generation In Human Lung Fibroblasts2014

    • Author(s)
      Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Kanai K, Yamamoto N, Ichinose M
    • Organizer
      2014 ATS International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells2014

    • Author(s)
      Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, and Ichinose M
    • Organizer
      2014 ATS International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] COPDの診断率向上と予後改善に向けた新たな戦略2014

    • Author(s)
      南方良章
    • Organizer
      日高医師会総会
    • Place of Presentation
      御坊市
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Changes in forced expiratiry volume in 1 second over time in patients with controlled asthma at baseline2014

    • Author(s)
      Matsunaga K, Ichikawa T, Oka A, Morishita Y, Kanai K, Hiramatsu M, Akamatsu H, Kawabata H, Kikuchi T, Akamatsu K, Hirano T, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] COPD患者の日常活動量に対する短時間作用性β2刺激薬・プロカテロールの効果の検討2014

    • Author(s)
      平野綱彦、小川浩正、赤松啓一郎、南方良章、松永和人、中西正典、市川朋宏、本多雄一、山本信之、一ノ瀬正和
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 日本人のCOPD患者におけるウメクリジニウム/ビランテロール(UMEC/VI)配合吸入用散剤の長期投与における安全性の検討2014

    • Author(s)
      南方良章、早乙女徹、三原加瑞子、橋本賢一
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ツロブテロール貼付剤のCOPD患者の身体活動性に対する効果2014

    • Author(s)
      平松政高、南方良章、森下友紀子、市川朋宏、赤松啓一郎、平野綱彦、中西正典、松永和人、一ノ瀬正和、山本信之
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Possibility of flying disc game for maintenance of physical activity in patients with long term oxygen therapy2013

    • Author(s)
      Honda Y, Minakata Y, Morishita Y, Hiramatsu M, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K
    • Organizer
      2013ATS International Conference
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Once-daily QVA149 is safe and well tolerated and improves lung function and health status in Japanese patients with COPD: the ARISE study2013

    • Author(s)
      Asai K, Minakata Y, Hirata K, Fukuchi Y, Kitawaki T, Ikeda K, Banerji D
    • Organizer
      2013 ERS Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Ongoing allergic rhinitis impairs asthma control by enhancing the lower airway inflammation2013

    • Author(s)
      Matsunaga K, Oka A, Kamei T, Sakammoto Y, Minakata Y
    • Organizer
      2013 ERS Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells2013

    • Author(s)
      Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
    • Organizer
      2013 ERS Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Ongoing Allergic Rhinitis Impairs Asthma Control By Enhancing The Lower Airway Inflammation2013

    • Author(s)
      Matsunaga K, Oka A, Kamei T, Sakamoto Y, Minakata Y
    • Organizer
      The 18th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] COPD臨床研究の可能性2013

    • Author(s)
      南方良章
    • Organizer
      COPD学術講演会
    • Place of Presentation
      姫路
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] COPD患者の活動性低下の強度別評価とその特徴2013

    • Author(s)
      南方良章
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 和歌山県におけるCOPDの現状と改善に向けた突破口2013

    • Author(s)
      南方良章
    • Organizer
      第475回和歌山市医師会内科部会講演会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Evaluation of intensity-based physical activity in patients with COPD2012

    • Author(s)
      Minakata Y, Sugino A, Honda Y, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, Sugiura H, Matsunaga K, Ichinose M
    • Organizer
      2012 ATS International Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 25-hydroxycholesterol enhances interferon release after Toll-like receptor 3 stimulation in human airway epithelial cells2012

    • Author(s)
      2. Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
    • Organizer
      2012 ATS International Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Persistant exhaled nitric oxide elevation and augmentation of inhaled corticosteroid therapy in asthma2012

    • Author(s)
      3. Hirano T, Matsunaga K, Sugiura H, Minakata Y, Koarai A, Akamatsu K, Ichikawa T, Furukawa K, Ichinose M
    • Organizer
      2012 ATS International Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 窒素化ストレスからみたCOPD-喘息との相違と小児期からの影響-2012

    • Author(s)
      南方良章
    • Organizer
      第49回日本小児アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] COPDの活動性2012

    • Author(s)
      南方良章
    • Organizer
      第33回日本呼吸器学会生涯教育講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Studies on Respiratory Disorders2014

    • Author(s)
      Matsunaga K, Minakata Y
    • Publisher
      Humana Press
    • Related Report
      2014 Annual Research Report
  • [Book] COPD治療におけるコンビネーションセラピー 病態理解から最新治療まで2014

    • Author(s)
      南方良章
    • Publisher
      医療ジャーナル社
    • Related Report
      2014 Annual Research Report
  • [Book] 今日の治療指針20142014

    • Author(s)
      南方良章
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] イラストでわかる呼吸器内科学2014

    • Author(s)
      南方良章
    • Publisher
      文光堂
    • Related Report
      2014 Annual Research Report
  • [Book] 第33回生涯教育講演会2012

    • Author(s)
      南方良章
    • Publisher
      社団法人日本呼吸器学会
    • Related Report
      2012 Research-status Report
  • [Book] 今日の治療指針2012

    • Author(s)
      南方良章
    • Total Pages
      262
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] Annual Review 呼吸器20122012

    • Author(s)
      南方良章、一ノ瀬正和
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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