| Project/Area Number |
24591137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWASAI Osamu 東北薬科大学, 薬学部, 准教授 (50296018)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 気管支喘息 / 肥満 / アレルギー性気道炎症 / 内臓脂肪 / アディポカイン / サイトカイン / アレルギー・ぜんそく / インスリン抵抗性 / 自然免疫 / 腫瘍壊死因子ーα / ガングリオシドＧＭ３ |
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| Outline of Final Research Achievements |
To provide the novel therapeutic strategies for obesity-related severe asthma, we investigated the pathophysiology of a murine allergic asthma model with high-fat diet-induced obesity (DIO). Compared with the lean mice, the DIO mice exhibited increased airways inflammation and airway responsiveness to Mch after antigen challenge. Bronchoalveolar lavage fluid and lung Th2 cytokine expression was increased in the DIO mice. In perirenal adipose tissue in the DIO mice, an increase in adiponectin mRNA expression and decreases in leptin, TNF-a, MCP-1, IL-10 mRNA expressions were observed, whereas, a remarkable increase in TNF-a mRNA expression and a remarkable decrease in IL-10 mRNA expression were observed after antigen challenge. These results suggest that the interaction between functional change of visceral adipose tissue and allergic airways inflammation may play an important role in the development of obesity-related severe asthma, providing new therapeutic targets for severe asthma.
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