| Project/Area Number |
24591139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Takeo 東京慈恵会医科大学, 医学部, 助教 (60366200)
ARAYA Jun 東京慈恵会医科大学, 医学部, 准教授 (90468679)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性閉塞性肺疾患 / フェノタイプ / 肺機能急速減衰 / 難治化増悪 / 全身性炎症 / 酸化ストレス / 喘息COPDオーバーラップ症候群 / ヘムオキシゲナーゼ-1 / 喘息合併COPD / 増悪 / クラム陰性桿菌 / 細菌定着 / Multiplex Real-time PCR / 肺機能 / 肺機能早期減衰 / TNF-alpha |
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| Outline of Final Research Achievements |
We studied the molecular and cellular markers associated with important clinical phenotypes of chronic pulmonary disease (COPD), “rapid decline of pulmonary function” and “refractory exacerbation of COPD”. As the results, rapid decline is associated with expansion of systemic inflammation with serum TNF-a level elevation. Refractory exacerbation of COPD is associated with triggering infection with enteric or non-fermenting Gram negative rods.
Furthermore, we evaluated systemic inflammation and oxidative stress among COPD, bronchial asthma (BA), and overlap of them (ACOS). Systemic inflammation is significantly higher in COPD/ACOS than BA, because of smoking-induced pathogenesis. Oxidative stress is significantly higher in COPD than BA/ACOS, because of reduction of anti-oxidative activity in COPD.
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