| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We studied the pathoetiology of COPD and obtained the following results: 1) In the lungs of COPD patients, chronic DNA damage contributes to cell senescence, apoptosis, chronic inflammation and tumorigenesis; 2) In mice exposed to cigarette smoke, oxidative damage occurs in the heart and adipose tissue as well as the lungs; 3) In mice repeatedly exposed to bromodeoxyuridine, chronic DNA damage causes persistent lung inflammation; 4) In mice repeatedly exposed to naphthalene, airway fibrosis occurs due to chronic airway epithelial injury; 5) In mice exposed to bleomycin, DNA damage in the lungs causes chronic lung inflammation; 6) Based on the above results, we proposed an evolutionary medicine approach to understand factors that contribute to the development of COPD.
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