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Analysis of particulate-induced allergic responses

Research Project

Project/Area Number 24591145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

Kuroda Etsushi  大阪大学, 免疫学フロンティア研究センター, 特任准教授 (10299604)

Co-Investigator(Kenkyū-buntansha) 森本 泰夫  産業医科大学, 産業生態科学研究所, 教授 (30258628)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords粒子状物質 / アラム / シリカ / IgE / ダメージ関連分子パターン / マクロファージ / 脂質メディエーター / プロスタグランジン / Syk
Outline of Final Research Achievements

Recently, the number of patients suffering from allergic diseases has increased especially in developed countries, and many studies have demonstrated that particle pollutants and environmental particles such as diesel exhaust, sand dust and PM2.5 may exacerbate allergic responses mediated by type 2 immune responses. However, the mechanisms by which particulates elicit type 2 responses remain poorly understood.
Intratracheal instillation of particulates and OVA induced antigen-specific IgE responses. These responses were regulated by a MyD88 dependent and IL-1 signaling pathway. Particulates stimulated alveolar macrophages to induce cell death and IL-1α release both in vitro and in vivo. Our results suggest that DAMPs released by particulate exposure play an important role in IgE induction and inflammation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Invited: 6 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen.2015

    • Author(s)
      Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley DM, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ.
    • Journal Title

      The Journal of Immunology

      Volume: 194 Issue: 6 Pages: 2673-2682

    • DOI

      10.4049/jimmunol.1402027

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.2015

    • Author(s)
      Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.
    • Journal Title

      Europeal Journal of Immunology

      Volume: 45 Issue: 4 Pages: 1159-1169

    • DOI

      10.1002/eji.201445132

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Significance of persistent inflammation in respiratory disorders induced by nanoparticles.2014

    • Author(s)
      Morimoto Y, Izumi H, Kuroda E.
    • Journal Title

      Journal of Immunology Research

      Volume: 2014 Pages: 962871-962871

    • DOI

      10.1155/2014/962871

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells2014

    • Author(s)
      Yasukawa. S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H
    • Journal Title

      Nature Comm

      Volume: 5 Issue: 1 Pages: 3755-3755

    • DOI

      10.1038/ncomms4755

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.2014

    • Author(s)
      Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 8 Pages: 3086-3091

    • DOI

      10.1073/pnas.1319268111

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis2014

    • Author(s)
      Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 3147-3147

    • DOI

      10.1038/ncomms4147

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] rostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.2013

    • Author(s)
      Sugita K, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K
    • Journal Title

      Scientific reports

      Volume: 3 Issue: 1 Pages: 2973-2973

    • DOI

      10.1038/srep02973

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pulmonary toxicity of printer toner following inhalation and intratracheal instillation.2013

    • Author(s)
      Y. Morimoto, T. Oyabu, M. Horie, T. Kambara, H. Izumi, E. Kuroda, O. Creutzenberg, B. Bellmann, G. Pohlmann, S. Schuchardt, T. Hansen, H. Ernst
    • Journal Title

      Inhalation Toxicology

      Volume: 12 Issue: 12 Pages: 679-690

    • DOI

      10.3109/08958378.2013.835010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] D1-like dopamine receptors antagonist inhibits cutaneous immune reactions mediated by Th2 and mast cells.2013

    • Author(s)
      T. Mori, K. Kabashima, S. Fukamachi, E. Kuroda, J. Sakabe, M. Kobayashi, S. Nakajima, K. Nakano, Y. Tanaka, S. Matsushita, M. Nakamura, Y. Tokura
    • Journal Title

      Journal of Dermatological Science

      Volume: 1 Issue: 1 Pages: 112-116

    • DOI

      10.1016/j.jdermsci.2013.03.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ワクチンアジュバントの功罪と開発2013

    • Author(s)
      黒田悦史、石井健
    • Journal Title

      感染・炎症・免疫

      Volume: 43 Pages: 74-77

    • Related Report
      2013 Research-status Report
  • [Journal Article] 粒子アジュバントの生体への影響 ワクチンアジュバントからDAMPs、大気汚染物質まで2013

    • Author(s)
      黒田悦史
    • Journal Title

      実験医学

      Volume: 31 Pages: 34-40

    • Related Report
      2013 Research-status Report
  • [Journal Article] Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.2013

    • Author(s)
      Kuroda E, Coban C, Ishii KJ
    • Journal Title

      International Reviews of Immunology

      Volume: 32 Issue: 2 Pages: 209-220

    • DOI

      10.3109/08830185.2013.773326

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 吸入性粒子状物質によるマクロファージの活性化とシグナル伝達経路の解析2013

    • Author(s)
      黒田悦史、堀江祐範、森本泰夫
    • Journal Title

      分子呼吸器病

      Volume: 17 Pages: 149-151

    • Related Report
      2012 Research-status Report
  • [Journal Article] 粒子アジュバントのメカニズム2012

    • Author(s)
      黒田悦史
    • Journal Title

      実験医学(増刊)

      Volume: 30 Pages: 203-208

    • Related Report
      2012 Research-status Report
  • [Journal Article] 粒子状物質によるTh2アジュバント効果2012

    • Author(s)
      黒田悦史
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 171-177

    • Related Report
      2012 Research-status Report
  • [Journal Article] アジュバントとしてのアルミニウム塩のTh2細胞誘導機構2012

    • Author(s)
      黒田悦史
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 204-209

    • NAID

      40019419069

    • Related Report
      2012 Research-status Report
  • [Presentation] 外来物質によるアレルギー性炎症のメカニズム2015

    • Author(s)
      黒田悦史、石井健
    • Organizer
      日本衛生学会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms of particulate-induced pulmonary inflammation ~Intrinsic adjuvant and allergy~2015

    • Author(s)
      Etsushi Kuroda
    • Organizer
      Society of Toxicology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-03-22 – 2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 粒子状物質により誘導される肺特異的免疫反応 ~なぜ粒子状物質の吸入によりアレルギー性炎症が誘導されるのか?~2015

    • Author(s)
      黒田悦史、石井健
    • Organizer
      次世代アジュバント研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-01-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Particulate-induced systemic IgE production is mediated by DAMPs released from alveolar macrophages2014

    • Author(s)
      Etsushi Kuroda, Koji Ozasa, Koji Kobiyama and Ken J Ishii
    • Organizer
      Cell Symposia Type 2 Immunity
    • Place of Presentation
      Brugge, Belgium
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粒子による内因性アジュバントの誘導とアレルギー性炎症2014

    • Author(s)
      黒田悦史、森本泰夫、石井健
    • Organizer
      日本毒性学会
    • Place of Presentation
      徳島
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粒子状物質の生体への影響 ~内因性アジュバント(DAMPs)とアレルギー~2014

    • Author(s)
      黒田悦史
    • Organizer
      日本毒性学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 粒子状物質により引き起こされる肺の炎症  ~DAMPsとアレルギー~2014

    • Author(s)
      黒田悦史、森本泰夫、石井健
    • Organizer
      肺サーファクタント分子病態研究会
    • Place of Presentation
      札幌
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粒子状物質の生体への影響 ー内因性アジュバントとアレルギー性炎症-2014

    • Author(s)
      黒田悦史、石井健
    • Organizer
      日本インターフェロン・サイトカイン学会
    • Place of Presentation
      札幌
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Particulate-induced systemic IgE production is mediated by DAMPs released from alveolar macrophages2014

    • Author(s)
      Etsushi Kuroda and Ken J Ishii
    • Organizer
      マクロファージ分子細胞生物学国際シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 粒子状物質の生体への影響 ~内因性アジュバント(DAMPs)とアレルギー~2014

    • Author(s)
      黒田悦史
    • Organizer
      第13回肺分子病態研究会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] DMXAA, a vascular disruptive agent, is a potent inhibitor of prostaglandin synthesis.2013

    • Author(s)
      Etsushi Kuroda, Keiichi Ohata and Ken J Ishii
    • Organizer
      The Joint International Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research, The 21st International Symposium on Molecular Cell Biology of Macrophages 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 粒子(アラム)アジュバント2013

    • Author(s)
      黒田悦史
    • Organizer
      第23回感染研シンポジウム 次世代型感染症ワクチンの戦略構想と展開 ―開発とレギュレーション-
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] DMXAA, a vascular disruptive agent, is a potent inhibitor of prostaglandin synthesis2013

    • Author(s)
      Etsushi Kuroda, Keiichi Ohata and Ken J Ishii
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      イタリア ミラノ
    • Related Report
      2013 Research-status Report
  • [Presentation] 粒子状物質により誘発される肺の炎症の解析2013

    • Author(s)
      黒田悦史
    • Organizer
      第20回日本免疫毒性学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of particulate-induced pulmonary allergic inflammation2013

    • Author(s)
      Etsushi Kuroda and Ken J Ishii
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Presentation] Particulates control immune responses via the production of lipid mediators.2012

    • Author(s)
      Etsushi Kuroda
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Particulates induce macrophage to produce lipid mediators via the Syk activation.2012

    • Author(s)
      Kuroda E, Ohata K, Coban C, Ishii JK
    • Organizer
      99th Annual Meeting of the The American Association of Immunologists
    • Place of Presentation
      Hynes Convention Center (Boston)
    • Related Report
      2012 Research-status Report
  • [Presentation] 吸入性粒子状物質によるマクロファージの活性化とシグナル伝達経路の解析

    • Author(s)
      黒田悦史、堀江祐範、森本泰夫
    • Organizer
      第11回肺サーファクタント分子病態研究会
    • Place of Presentation
      札幌医科大学記念ホール(札幌)
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] アレルギー誘発物質の検査、アレルギーの診断および治療2014

    • Inventor(s)
      石井健、黒田悦史
    • Industrial Property Rights Holder
      石井健、黒田悦史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-111576
    • Filing Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 異なる核酸アジュバントの組み合わせによる新規Th1誘導性アジュバントおよびその用途2014

    • Inventor(s)
      石井健、黒田悦史、Burcu temizoz
    • Industrial Property Rights Holder
      石井健、黒田悦史、Burcu temizoz
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-235934
    • Filing Date
      2014-11-20
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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