| Project/Area Number |
24591149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
OHKOUCHI Shinya 東北大学, 環境・安全推進センター, 講師 (40375035)
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| Co-Investigator(Kenkyū-buntansha) |
EBINA Masahito 東北薬科大学, 病院, 教授 (10280885)
兼平 雅彦 東北大学, 大学病院, 助教 (90374941)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEHIRA Masahiko 東北大学, 大学院医学研究科, 助教 (90374941)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 間葉系幹細胞 / 特発性肺線維症 / 間質性肺炎 / 小胞体ストレス / 過酸化ストレス / 骨髄間葉系幹細胞 / 液性因子 / 治療 / 成長因子 / TGF-BETA / STC1 / 国際情報交換 / ワルブルグ効果 / アメリカ合衆国 |
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| Outline of Final Research Achievements |
Continuous ER-stress changes the secretary status of AECs and increase the synthesis, and secretion of pro-fibrotic humoral factors including TGF-beta 1 from AECs. TGF-beta 1 promotes the change from fibroblasts to myo-fibroblasts which is essential for the formation of fibrosis. Recent studies show that Mesenchymal stem cells (MSCs) ameliorate fibrosis in bleomycin inhalation mice (IPF model mice). MSCs can reduce ER-stress of cells in microenvironment under harmful conditions however that mechanism is still unknown. We has shown that protein hormone STC1 reduce endothelium reticulum stress (ER-stress) pulmonary fibrosis in Bleomycin-induced fibrosis mice. We published our work in Molecular Therapy, 2015, 23, 549.
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