Basic research aimed at application as pulmonary fibrosis treatment of new biologically active substances, SCGB3A2
| Project/Area Number |
24591151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
Kurotani Reiko 山形大学, 理工学研究科, 准教授 (00453043)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Hiroyuki 山形大学, 大学院理工学研究科, 教授 (10375199)
SHIBATA Yoko 山形大学, 医学部, 講師 (60333978)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMAKI Nobue 東海大学, 医学部, 講師 (90366021)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | SCGB3A2 / 肺線維症 / ＳＣＧＢ３Ａ２ / ブレオマイシン / トレッドミル / アポトーシス |
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| Outline of Final Research Achievements |
Pulmonary fibrosis is induced to develop by the side effects of bleomycin (BLM), which is used as a radiation and anti-cancer agent in the treatment of cancer. Since the pathogenesis of pulmonary fibrosis is not sufficient, and definitive therapeutic agent is not present, elucidation of the onset mechanism of pulmonary fibrosis and the development of the new therapeutic drug become the urgent business. New bioactive substance Secretoglobin (SCGB)3A2 has roles of the anti-inflammatory effect, pulmonary fibrosis improvement effect, as well as promotes growth, branching, and maturation in the lung development. SCGB3A2 having such a multi-function was expected to be physiologically active substances with the potential as an effective treatment of pulmonary fibrosis. This study demonstrated the possible therapeutic use of SCGB3A2 in treatment of lung fibrosis.
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Report
(5 results)
Research Products
(91 results)
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[Journal Article] A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.2015
Author(s)
Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I and Ishikawa Y.
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Journal Title
Sci. Rep.
Volume: 5
Issue: 1
Pages: 9194-9194
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.2014
Author(s)
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
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Journal Title
J Clin Invest.
Volume: 124
Issue: 6
Pages: 2785-2801
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Disruption of Epac1 decreases phosphorylation of phospholamban and protects the heart against stresses.2014
Author(s)
Okumura S, Fujita T, Cai W, Jin M, Nakamyra I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, et al.
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Journal Title
J Clin Invest
Volume: 印刷中
Related Report
Peer Reviewed
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[Presentation] Analyses of respiration activity in single culture cells2012
Author(s)
Takakura K, Watanabe T, Sakahara S, Kurotani R, Abe H
Organizer
International Joint Symposium on Single-Cell Analysis (The 6th International Workshop on Approaches to Single-Cell Analysis & The 8th International Forum on Post-Genome Technologies)
Place of Presentation
Kyoto Research Park, Kyoto
Related Report
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