Identification of host factors which protect against the development of pulmonary inflammation induced by intracellular pathogens
Project/Area Number |
24591152
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | University of Tsukuba |
Principal Investigator |
ISHII Yukio 筑波大学, 医学医療系, 教授 (80272194)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 転写因子 / インフルエンザ / レジオネラ肺炎 / 非結核性抗酸菌症 / マクロファージ / T細胞 / 酸化ストレス / 炎症 / 宿主応答 / 非結核性抗酸菌 / レジオネラ / T-bet / SQSTM1 / T細胞 / T-bet / SQSTM1 / 細胞内寄生菌 / ヘルパーT細胞 |
Outline of Final Research Achievements |
In this study, the protective roles of Nrf2, p62, and T-bet in the development of lung inflammation induced by intracellular pathogens are investigated. Nrf2 is a transcription factor involved in cellular protection against oxidative stimuli. The antioxidant pathway controlled by Nrf2 is found to be pivotal in protection against the development of influenza virus-induced pulmonary inflammation and injury under oxidative conditions. P62, a scaffold multifunctional protein involved in several cellular events, is found to be a negative regulator of acute pulmonary inflammation during Legionnaires’disease, possibly by regulating inflammasome activity and subsequent proinflammatory cytokine production. T-bet, the master regulator for Th1 development, is found to be a critical regulator for susceptibility and inflammatory responses to M. avium. T-bet-deficient mice are highly susceptible to M. avium infection with diminishment of Th1 responses and development of Th17 responses.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Role of Th1/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease.2014
Author(s)
Matsuyama M, Ishii Y, Yageta Y, Ohtsuka S, Ano S, Matsuno Y, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hogaboam CM, Hizawa N.
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Journal Title
Journal of Immunology
Volume: 192
Issue: 4
Pages: 1707-1717
DOI
Related Report
Peer Reviewed
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