Investigation of nitrosative stress and new inflammatory mediator in patients with eosinophilic pneumonia

• Project/Area Number: 24591174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: AKAMATSU Keiichiro 和歌山県立医科大学, 医学部, 講師 (60405412)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 好酸球性肺炎 / 窒素化ストレス / サイトカイン / ケモカイン / 成長因子

Outline of Final Research Achievements

Acute-onset interstitial lung diseases (ILD) comprise a group of heterogeneous disorders. It is important to identify the underlying lung disease, as it may influence clinical outcomes. We aimed to determine whether there are differences in exhaled nitric oxide (eNO) between different subtypes of acute-onset ILD. eNO could be a marker for differentiating EP from other types of acute-onset ILD regardless of blood eosinophil levels.

Research Products

• [Journal Article] Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells. (2015)
  • Author(s): K. Kanai, A. Koarai, Y.Shishikura, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M.Ichinose.
  • Journal Title: Respir Investig. Volume: in press Issue: 4 Pages: 137-148
  • DOI: 10.1016/j.resinv.2015.01.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Stratifying the risk of COPD exacerbati on using the modified Medical Research Council scale: A multicenter cross-sectional CAP study. (2015)
  • Author(s): Matsunaga, K, A. Hayata, K. Akamatsu, T. Hirano, T. Tamada, T. Kamei, T. Tsuda, H. Nakamura, T. Takahashi, S. Hozawa, Y. Mori, Y. Sakamoto, K. Kimura, U. Katsumata, M. Miura, M. Ichinose.
  • Journal Title: Respiratory Investigation Volume: 53 Issue: 2 Pages: 82-85
  • DOI: 10.1016/j.resinv.2014.10.006
  • Peer Reviewed / Open Access
• [Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. (2014)
  • Author(s): Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
  • Journal Title: J Immunol Volume: 192 Issue: 11 Pages: 4977-4988
  • DOI: 10.4049/jimmunol.1302919
  • Peer Reviewed
• [Journal Article] Changes in forced expiratory volume in 1 second over time in patients with controlled asthma at baseline (2014)
  • Author(s): Kazuto Matsunaga
  • Journal Title: Respiratory Medicine Volume: 108 Issue: 7 Pages: 976-982
  • DOI: 10.1016/j.rmed.2014.04.014
  • Peer Reviewed
• [Journal Article] Ongoing Allergic Rhinitis Impairs Asthma Control by Enhancing the Lower Airway Inflammation (2014)
  • Author(s): Oka A, Matsunaga K, Kamei T, Sakamoto Y, Hirano T, Hayata A, Akamatsu K, Kikuchi T, Hiramatsu M, Ichikawa T, Nakanishi M, Minakata Y, Yamamoto N
  • Journal Title: J Allergy Clin Immunol Pract Volume: 2 Issue: 2 Pages: 172-178
  • DOI: 10.1016/j.jaip.2013.09.018
  • Peer Reviewed
• [Journal Article] Natural history and risk factors of obstructive changes over a 10-year period in severe asthma (2013)
  • Author(s): Matsunaga K
  • Journal Title: Respir Med Volume: 107 Issue: 3 Pages: 355-360
  • DOI: 10.1016/j.rmed.2012.11.014
  • Peer Reviewed
• [Journal Article] Persistent elevation of exhaled nitric oxide and modification of corticosteroid therapy in asthma. (2013)
  • Author(s): T. Hirano, H. Sugiura et al.
  • Journal Title: Respir Invest Volume: 51 Issue: 2 Pages: 84-91
  • DOI: 10.1016/j.resinv.2013.01.002
  • Peer Reviewed
• [Journal Article] Stratifying a Risk for an Increased Variation of Airway Caliber among the Clinically Stable Asthma (2013)
  • Author(s): Hayata A, Matsunaga K, Hirano T, Akamatsu K, Ichikawa T, Minakata Y, Ichinose M
  • Journal Title: Allergology International Volume: 62 Issue: 3 Pages: 343-349
  • DOI: 10.2332/allergolint.13-OA-0543
  • NAID: 130004477196
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Predictors for Identifying the Efficacy of Systemic Steroids on Sustained Exhaled Nitric Oxide Elevation in Severe Asthma (2013)
  • Author(s): Matsunaga K, Hirano T, Akamatsu K, Minakata Y
  • Journal Title: Allergology International Volume: 62 Issue: 3 Pages: 359-365
  • DOI: 10.2332/allergolint.12-OA-0530
  • NAID: 130004477190
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Relationship between alveolar nitric oxide concentration in exhaled air and small airway function in COPD. (2013)
  • Author(s): T. Hirano, H. Sugiura et al.
  • Journal Title: J Breath Res Volume: 7 Issue: 4 Pages: 046002-046002
  • DOI: 10.1088/1752-7155/7/4/046002
  • Peer Reviewed
• [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics. (2012)
  • Author(s): Matsunaga K
  • Journal Title: Clin Exp Allergy Volume: 42 Issue: 5 Pages: 775-781
  • DOI: 10.1111/j.1365-2222.2011.03945.x
  • Peer Reviewed
• [Journal Article] Response to treatment in individuals with late-onset asthma. (2012)
  • Author(s): Matsunaga K
  • Journal Title: J Am Geriatric Soc Volume: 60 Issue: 8 Pages: 1587-1588
  • DOI: 10.1111/j.1532-5415.2012.04083.x
  • Peer Reviewed
• [Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27-hydroxycholesterol in tissue fibrosis. (2012)
  • Author(s): Kikuchi T
  • Journal Title: Chest Volume: 142 Pages: 329-337
  • Peer Reviewed
• [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts. (2012)
  • Author(s): Sugiura H
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 302
  • Peer Reviewed
• [Presentation] mMRC質問票を用いたCOPD増悪リスクの層別化：多施設共同CAP study (2014)
  • Author(s): 4.松永和人, 早田敦志, 赤松啓一郎, 平野綱彦, 玉田勉, 亀井雅, 津田徹, 中村洋之, 高橋誠至, 保澤総一郎, 森由弘, 坂本幸裕, 木村啓二, 勝又宇一郎, 三浦元彦, 一ノ瀬正和
  • Organizer: 第11回呼吸器バイオマーカー研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-29
• [Presentation] LATE-BREAKING ABSTRACT: ASSOCIATION OF SEVERE EXACERBATION WITH FEV1 DECLINE AND LOSS OF AIRWAY REVERSIBILITY ASTHMA. (2014)
  • Author(s): Matsunaga K, Ichikawa T, Akamatsu K, Hirano T
  • Organizer: 2014 ERS International Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells. (2014)
  • Author(s): Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, and Ichinose M
  • Organizer: 2014 ATS International Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-22
• [Presentation] 長期管理中の喘息患者における気道閉塞の進展：重症増悪の影響 (2014)
  • Author(s): 7.松永和人, 岡亜早子, 市川朋宏, 平野綱彦, 赤松啓一郎, 中西正典
  • Organizer: 第26回日本アレルギー学会春季臨床大会(ミニシンポジウム)
  • Place of Presentation: 京都市
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] Changes in forced expiratiry volume in 1 second over time in patients with controlled asthma at baseline. (2014)
  • Author(s): Matsunaga K, Ichikawa T, Oka A, Morishita Y, Kanai K, Hiramatsu M, Akamatsu H, Kawabata H, Kikuchi T, Akamatsu K, Hirano T, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
  • Organizer: The 54th Annual Meeting of The Japanese Respiratory Society
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2014-04-27
• [Presentation] 重症喘息における閉塞性障害の長期的な進行経過
  • Author(s): 赤松 啓一郎
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] 鼻炎合併喘息における喘息コントロール不良の独立した規定因子
  • Author(s): 松永和人
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
• [Presentation] アレルギー性鼻炎と喘息: 上気道と下気道の関連機序の検討
  • Author(s): 松永和人
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] Possibility of flying disc game for maintenance of physical activity in patients with long term oxygen therapy
  • Author(s): Y. Honda
  • Organizer: 2013 ATS International Conference
  • Place of Presentation: Philadelphia, USA
• [Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells
  • Author(s): K. Kanai
  • Organizer: 2013 ERS Annual Congress
  • Place of Presentation: Barcelona, Spain
• [Presentation] COPDと喘息の合併症例について
  • Author(s): 赤松 啓一郎
  • Organizer: 第37回呼吸器疾患研究会
  • Place of Presentation: 和歌山
• [Presentation] 重症喘息における閉塞性障害の長期的な進行経過
  • Author(s): 赤松 啓一郎
  • Organizer: 第86回閉塞性肺疾患研究会
  • Place of Presentation: 東京
• [Presentation] Independent Predictors Of Persistent Exhaled Nitric Oxide Elevation In Treated Asthmatics.
  • Author(s): K. Matsunaga
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, USA
• [Presentation] Developing obstructive change over time is dominant in small airways in severe asthma.
  • Author(s): K. Matsunaga
  • Organizer: 2012 ERS Annual Congress
  • Place of Presentation: Vienna, Austria
• [Presentation] 高齢発症喘息におけるHFA-fluticasone/salmeterol配合剤の治療反応性
  • Author(s): 松永 和人
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪