| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To elucidate the role of nitric oxide (NO) and nitric oxide synthase (NOS) in several respiratory disorders, we performed bleomycin-induced pulmonary fibrosis and bacterial pneumonia induced by intratracheal administration of bacteria to evaluate the roles of nitric oxide (NO) in several respiratory disease using mice lacking all three isoforms of n/i/e (nitric oxide synthase; NOS). As a result, n/i/e (nitric oxide synthase; NOS that all of NOS were deficient, showed protective effects of NO in bleomycin-induced pulmonary fibrosis model,and similar protective effect of NO in bacterial pneumonia mode that NO has protective effect on bleomycin-induced pulmonary fibrosis and bacterial pneumonia in mice.
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