Role of prolactin receptor in kidney glomerular podocyte

• Project/Area Number: 24591191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: KANEKO Yoshikatsu 新潟大学, 医歯学系, 助教 (80444157)
• Co-Investigator(Kenkyū-buntansha): NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: プロラクチン / プロラクチン受容体 / 糸球体上皮細胞 / ポドサイト / 腎炎モデル

Outline of Final Research Achievements

Prolactin receptor has been reported to be expressed in kidney tubular cells and to be associated with natriuresis, but its expression in kidney glomerular podocyte was not known. In order to clarify the role of prolactin receptor in glomerular podocyte, we generated transgenic mice in which human prolactin receptor was expressed in glomerular podocyte specifically. We verified that human prolactin receptor was expressed in glomerular podocyte in transgenic mice, but the phenotypic difference with wild type mice was not observed in the condition of hyperprolactinemia, and further investigation should be continued.