Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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Outline of Final Research Achievements |
Prolactin receptor has been reported to be expressed in kidney tubular cells and to be associated with natriuresis, but its expression in kidney glomerular podocyte was not known. In order to clarify the role of prolactin receptor in glomerular podocyte, we generated transgenic mice in which human prolactin receptor was expressed in glomerular podocyte specifically. We verified that human prolactin receptor was expressed in glomerular podocyte in transgenic mice, but the phenotypic difference with wild type mice was not observed in the condition of hyperprolactinemia, and further investigation should be continued.
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