Research Project
Grant-in-Aid for Scientific Research (C)
Autophagy plays an essential role for cellular homeostasis. We have previously demonstrated that autophagy protects against ischemia-reperfusion or nephrotoxic injury. Here we tested whether autophagy is involved in kidney aging. Age-dependent high basal autophagy plays a crucial role in counteracting kidney aging through mitochondrial quality control but that lack of up-regulation of autophagic flux in response to metabolic stress with age is associated with age-related kidney diseases. Furthermore, we tested whether autophagy is involved in cellular adaptations of the proximal tubular cell against chronic metabolic acidosis through mitochondrial homeostasis. Metabolic acidosis induces autophagy in the proximal tubular cell, which is indispensable for maintaining proper mitochondrial functions including ammoniagenesis, and thus for adapted urinary acid excretion. These two results provide a new therapeutic option for age-related kidney disease and acidosis by modulating autophagy.
All 2015 2014 2013 2012 Other
All Journal Article (5 results) (of which Acknowledgement Compliant: 1 results, Peer Reviewed: 3 results) Presentation (9 results) (of which Invited: 2 results) Remarks (2 results)
腎臓内科・泌尿器科
Volume: 未定
40022582461
J Am Soc Nephrol
Nephrol Dial Transplant
Volume: 未定 Issue: 9 Pages: 1639-1647
10.1093/ndt/gft535
Autophagy
Volume: 9 Issue: 11 Pages: 1876-1886
10.4161/auto.25418
日本腎臓学会誌
Volume: 54 Pages: 78-85
10030563626
http://www.med.osaka-u.ac.jp/pub/kid/kid/index.html
