| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Autophagy is a cellular process involved in the bulk degradation of proteins and organelle turnover. This study aimed to elucidate the morphological evidence for autophagy and its association with ultrastructural alterations of podocytes and clinical parameters in patients with minimal change nephrotic syndrome (MCNS). Autophagic vacuoles were particularly detected in podocytes. Overall, the number of autophagic vacuoles in podocytes was significantly correlated with age. In the patients with MCNS, the number of autophagic vacuoles in podocytes was significantly correlated with the podocyte foot process effacement (FPE) score, the amount of proteinuria and the level of serum albumin. The number of autophagic vacuoles in podocytes was significantly increased in the patients with MCNS and MN in comparison to that observed in the patients with IgAN and LN. The data indicate that the autophagy of podocytes is associated with FPE and massive proteinuria in patients with MCNS.
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