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Systematic identification of serine proteases involved in the progression of CKD

Research Project

Project/Area Number 24591206
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Yamanashi (2014)
Kumamoto University (2012-2013)

Principal Investigator

KITAMURA Kenichiro  山梨大学, 大学院総合研究部, 教授 (10304990)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords慢性腎不全 / セリンプロテアーゼ / タンパク尿 / 慢性腎臓病
Outline of Final Research Achievements

Few therapeutic strategies have been established for the treatment of chronic kidney diseases (CKD). Therefore, to develop a new class of the drugs is absolutely required for the patients with CKD to avoid the renal replacement therapy. Here, we demonstrated that a serine protease inhibitor significantly reduced the progression of CKD by ameliorating the glomerulosclerosis and by inhibiting the interstitial fibrosis, which suggests that serine proteases are involved in the development of the progression of CKD. In addition, we isolated plasmin as a candidate serine protease involved in the aldosterone induced renal injury.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Acknowledgement Compliant: 1 results,  Open Access: 2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals.2014

    • Author(s)
      Shiraishi N, Kitamura K, Hayata M, Ogata T, Tajiri-Okamura K, Nakayama Y, Kohda Y, Tomita K, Mukoyama M.
    • Journal Title

      Am J Kidney Dis.

      Volume: 65 Issue: 3 Pages: 490-493

    • DOI

      10.1053/j.ajkd.2014.09.028

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients.2014

    • Author(s)
      Kuragano T, Matsumura O, Matsuda A, Hara T, Kiyomoto H, Murata T, Kitamura K, Fujimoto S, Hase H, Joki N, Fukatsu A, Inoue T, Itakura I, Nakanishi T.
    • Journal Title

      Kidney Int.

      Volume: 86 Issue: 4 Pages: 845-854

    • DOI

      10.1038/ki.2014.114

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.2014

    • Author(s)
      Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K.
    • Journal Title

      Nat Commun.

      Volume: 11 Issue: 1 Pages: 3428-3428

    • DOI

      10.1038/ncomms4428

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population.2014

    • Author(s)
      Shiraishi N, Kitamura K, Kohda Y, Iseki K, Tomita K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 18 Issue: 3 Pages: 461-468

    • DOI

      10.1007/s10157-013-0833-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The antifibrotic effect of a serine protease inhibitor in the kidney2013

    • Author(s)
      Morinaga, J., Kakizoe, Y., Miyoshi, T., Onoue, T., Ueda, M., Mizumoto, T., Yamazoe, R., Uchimura, K., Hayata, M., Shiraishi, N., Adachi, M., Sakai, Y., Tomita, K., and Kitamura, K.
    • Journal Title

      Am. J. Physiol. (Renal Physiol.)

      Volume: 305 Issue: 2 Pages: F173-F181

    • DOI

      10.1152/ajprenal.00586.2012

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urinary prostasin in normotensive individuals: correlation with the aldosterone to renin ratio and urinary sodium2013

    • Author(s)
      Olivieri, O., Chiecchi, L., Pizzolo, F., Castagna, A., Raffaelli, R., Gunasekaran, M., Guarini, P., Consoli, L., Salvagno, G., and Kitamura, K.
    • Journal Title

      Hypertens. Res.

      Volume: 36 Issue: 6 Pages: 528-533

    • DOI

      10.1038/hr.2012.232

    • NAID

      10031189657

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension.2013

    • Author(s)
      Wakui H, Tamura K, Masuda S, Tsurumi-Ikeya Y, Fujita M, Maeda A, Ohsawa M, Azushima K, Uneda K, Matsuda M, Kitamura K, Uchida S, Toya Y, Kobori H, Nagahama K, Yamashita A, Umemura S.
    • Journal Title

      Hypertension.

      Volume: 61(6) Issue: 6 Pages: 1203-10

    • DOI

      10.1161/hypertensionaha.111.00572

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renin Angiotensin Antagonist Nromalize Aberrant Activation of Epithelial Sodium Channels in Sodium-Sensitive Hypertension2013

    • Author(s)
      Hisako Uchio-Yamana, Shintaro Minegishi, Tomoaki Ishigami, et al.
    • Journal Title

      Nephron Experimental Nephrology

      Volume: 122 Issue: 3-4 Pages: 95-102

    • DOI

      10.1159/000348660

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of a serine protease inhibitor on the progression of chronic renal failure2012

    • Author(s)
      Hayata, M., Kakizoe, Y., Uchimura, K., Morinaga, J., Yamazoe, R., Mizumoto, T., Onoue, T., Ueda, M., Shiraishi, N., Adachi, M., Miyoshi, T., Sakai, Y., Tomita, K., and Kitamura, K.
    • Journal Title

      Am. J. Physiol. (Renal Physiol.)

      Volume: 303 Issue: 8 Pages: F1126-F1135

    • DOI

      10.1152/ajprenal.00706.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats2012

    • Author(s)
      Uchimura, K., Kakizoe, Y., Onoue, T., Hayata, M., Morinaga, J., Yamazoe, R., Ueda, M., Mizumoto, T., Adachi, M., Miyoshi, T., Shiraishi, N., Sakai, Y., Tomita, K., and Kitamura, K.
    • Journal Title

      Am. J. Physiol. (Renal Physiol.)

      Volume: 303 Issue: 7 Pages: F939-F943

    • DOI

      10.1152/ajprenal.00705.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of acetaminophen on progression of renal damage in adenine induced renal failure model rat.2012

    • Author(s)
      Kadowaki D, Sumikawa S, Arimizu K, Taguchi K, Kitamura K, Ishitsuka Y, Narita Y, Irie T, Maruyama T, Otagiri M, Hirata S
    • Journal Title

      Life Sci.

      Volume: 91 Issue: 25-26 Pages: 1304-1308

    • DOI

      10.1016/j.lfs.2012.09.018

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] プロスタシンによるTLR4の発現制御を介した肝臓におけるインスリン抵抗性発症機序の解明2014

    • Author(s)
      内村 幸平, 早田 学, 水本 輝彦, 柿添 豊, 福田 一起, 近藤 龍也, 松村 剛, 荒木 栄一, 向山 政志, 北村 健一郎
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      横浜市開港記念会館(神奈川県横浜市)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ANGPTL2は腎線維化を促進する2014

    • Author(s)
      森永 潤, 北村 健一郎, 冨田 公夫, 尾池 雄一
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Remarks] 山梨大学医学部内科学講座第3教室ホームページ

    • URL

      http://yamanashi-3nai.com/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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