Systematic identification of serine proteases involved in the progression of CKD
Project/Area Number |
24591206
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | University of Yamanashi (2014) Kumamoto University (2012-2013) |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 慢性腎不全 / セリンプロテアーゼ / タンパク尿 / 慢性腎臓病 |
Outline of Final Research Achievements |
Few therapeutic strategies have been established for the treatment of chronic kidney diseases (CKD). Therefore, to develop a new class of the drugs is absolutely required for the patients with CKD to avoid the renal replacement therapy. Here, we demonstrated that a serine protease inhibitor significantly reduced the progression of CKD by ameliorating the glomerulosclerosis and by inhibiting the interstitial fibrosis, which suggests that serine proteases are involved in the development of the progression of CKD. In addition, we isolated plasmin as a candidate serine protease involved in the aldosterone induced renal injury.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients.2014
Author(s)
Kuragano T, Matsumura O, Matsuda A, Hara T, Kiyomoto H, Murata T, Kitamura K, Fujimoto S, Hase H, Joki N, Fukatsu A, Inoue T, Itakura I, Nakanishi T.
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Journal Title
Kidney Int.
Volume: 86
Issue: 4
Pages: 845-854
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.2014
Author(s)
Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K.
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Journal Title
Nat Commun.
Volume: 11
Issue: 1
Pages: 3428-3428
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The antifibrotic effect of a serine protease inhibitor in the kidney2013
Author(s)
Morinaga, J., Kakizoe, Y., Miyoshi, T., Onoue, T., Ueda, M., Mizumoto, T., Yamazoe, R., Uchimura, K., Hayata, M., Shiraishi, N., Adachi, M., Sakai, Y., Tomita, K., and Kitamura, K.
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Journal Title
Am. J. Physiol. (Renal Physiol.)
Volume: 305
Issue: 2
Pages: F173-F181
DOI
Related Report
Peer Reviewed
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[Journal Article] Urinary prostasin in normotensive individuals: correlation with the aldosterone to renin ratio and urinary sodium2013
Author(s)
Olivieri, O., Chiecchi, L., Pizzolo, F., Castagna, A., Raffaelli, R., Gunasekaran, M., Guarini, P., Consoli, L., Salvagno, G., and Kitamura, K.
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Journal Title
Hypertens. Res.
Volume: 36
Issue: 6
Pages: 528-533
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension.2013
Author(s)
Wakui H, Tamura K, Masuda S, Tsurumi-Ikeya Y, Fujita M, Maeda A, Ohsawa M, Azushima K, Uneda K, Matsuda M, Kitamura K, Uchida S, Toya Y, Kobori H, Nagahama K, Yamashita A, Umemura S.
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Journal Title
Hypertension.
Volume: 61(6)
Issue: 6
Pages: 1203-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of a serine protease inhibitor on the progression of chronic renal failure2012
Author(s)
Hayata, M., Kakizoe, Y., Uchimura, K., Morinaga, J., Yamazoe, R., Mizumoto, T., Onoue, T., Ueda, M., Shiraishi, N., Adachi, M., Miyoshi, T., Sakai, Y., Tomita, K., and Kitamura, K.
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Journal Title
Am. J. Physiol. (Renal Physiol.)
Volume: 303
Issue: 8
Pages: F1126-F1135
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats2012
Author(s)
Uchimura, K., Kakizoe, Y., Onoue, T., Hayata, M., Morinaga, J., Yamazoe, R., Ueda, M., Mizumoto, T., Adachi, M., Miyoshi, T., Shiraishi, N., Sakai, Y., Tomita, K., and Kitamura, K.
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Journal Title
Am. J. Physiol. (Renal Physiol.)
Volume: 303
Issue: 7
Pages: F939-F943
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of acetaminophen on progression of renal damage in adenine induced renal failure model rat.2012
Author(s)
Kadowaki D, Sumikawa S, Arimizu K, Taguchi K, Kitamura K, Ishitsuka Y, Narita Y, Irie T, Maruyama T, Otagiri M, Hirata S
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Journal Title
Life Sci.
Volume: 91
Issue: 25-26
Pages: 1304-1308
DOI
Related Report
Peer Reviewed
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