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Study of the significance of intermittent hypoxia on risk management of chronic kidney disease

Research Project

Project/Area Number 24591208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionFukushima Medical University

Principal Investigator

ASAHI Koichi  福島県立医科大学, 医学部, 准教授 (60274966)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Masaaki  福島県立医科大学, 医学部, 教授 (60217940)
Co-Investigator(Renkei-kenkyūsha) WATANABE Tsuyoshi  福島県立医科大学, 医学部, 教授 (80158641)
Research Collaborator WATANABE Kimio  福島県立医科大学, 医学部, 助教 (20595607)
KANNO Makoto  福島県立医科大学, 医学部, 助教 (60746014)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords慢性腎臓病 / 酸化ストレス / 虚血 / 臓器連関
Outline of Final Research Achievements

This study aimed to clarify the association between hypoxia related conditions and cerebro-, cardio-renal interaction and to elucidate their significance in the risk management of chronic kidney disease.
First, we studied the association between uremic conditions and cognitive impairment in rat uremia model that orally administered methylglyoxal. Secondly, we examined the relationship between renal ischemia and myocardial damage. Thirdly, we established large CKD (and CKD high risk) outpatients’ cohort to evaluate their clinical characteristics including the sleep disordered breathing.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (11 results)

  • [Journal Article] Skin autofluorescence predicts cardiovascular mortality in patients on chronic hemodialysis2014

    • Author(s)
      Kimura H, Tanaka K, Asahi K, Nakayama M, Miyata T, Watanabe T et al.
    • Journal Title

      Ther Apher Dial

      Volume: 18 Pages: 461-467

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?2014

    • Author(s)
      Watanabe K, Okada K, Asahi K, Watanabe T, Nakayama M et al.
    • Journal Title

      Toxins

      Volume: 6 Pages: 254-269

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylglyoxal (MG) and cerebro-renal interaction: Does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?2014

    • Author(s)
      Watanabe K, Asahi K et al.
    • Journal Title

      Toxins

      Volume: 6 Pages: 254-269

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advanced glycation end product accumulation, measured as skin autofluorescence, predicts the progression of chronic kidney disease2013

    • Author(s)
      Tanaka K, Asahi K et al.
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells2012

    • Author(s)
      Hayashi Y, Asahi K, Nakayama M, Watanabe T, et al.
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 690-696

    • NAID

      10031122255

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of Japanese MPO-ANCA-related nephritis: Significance of initial renal death for survival2012

    • Author(s)
      Watanabe K, Asahi K, Nakayama M, Watanabe T, et al.
    • Journal Title

      Intern Med

      Volume: 51 Pages: 1969-1976

    • NAID

      130002062274

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blood pressure control in patients with chronic kidney disease2012

    • Author(s)
      Tanaka K, Asahi K, Nakayama M, Watanabe T, et al
    • Journal Title

      Am J Hypertens

      Volume: 25 Pages: 951-954

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes2012

    • Author(s)
      Tanaka K, Asahi K, Nakayama M, Watanabe T, et al
    • Journal Title

      Diabetes Med

      Volume: 29 Pages: 492-500

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship between the serum uric acid level and renal progression in patients with chronic kidney disease: a prospective, observational study2014

    • Author(s)
      Kimura H, Tanaka K, Asahi K, Nakayama M, Watanabe T et al.
    • Organizer
      ASN Kidney Week 2014
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性腎臓病患者の血圧管理の実態についてー福島CKDコホート研究ー2014

    • Author(s)
      田中健一、中山昌明、旭浩一、渡辺毅ら
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] メチルグリオキサール(MGO)と脳腎連関障害:正常SDラットの長期MGO投与の影響に関する検討2014

    • Author(s)
      渡邉公雄、旭浩一、渡辺毅、中山昌明ら
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 片側虚血再潅流障害におけるロスバスタチンの遠隔臓器保護作用についての検討2014

    • Author(s)
      菅野真理、中山昌明、旭浩一、渡辺毅ら
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Methylglyoxal (MG) and cerebro-renal interaction: Does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?2014

    • Author(s)
      Watanabe K, Asahi K et al.
    • Organizer
      8th International Congress on Uremia Research and Toxicity
    • Place of Presentation
      Okinawa, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] The effect of Pioglitzone on mitochondrial biogenesis in the kidney of Dahl salt sensitive hypertension rat2013

    • Author(s)
      Hayashi Y, Asahi K et al.
    • Organizer
      Kidney Week 2013(Annual Meeting of American Society of Nephrology)
    • Place of Presentation
      Atlanta, GA
    • Related Report
      2013 Research-status Report
  • [Presentation] Skin autofluorescence predicts cardiovascular mortality in patients on chronic hemodialysis2013

    • Author(s)
      Kimura H, Asahi K et al.
    • Organizer
      Kidney Week 2013(Annual Meeting of American Society of Nephrology)
    • Place of Presentation
      Atlanta, GA
    • Related Report
      2013 Research-status Report
  • [Presentation] 尿毒症物質メチルグリオキサールによる認知機能障害に関する研究2013

    • Author(s)
      渡邉公雄、旭浩一ら
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 皮膚AGE蓄積は慢性腎臓病の腎予後を予測する2013

    • Author(s)
      田中健一、旭浩一ら
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Home blood pressure control after the Great East Japan Earthquake is associated with renin-angiotensin system inhibitor medications in hemodialysis patients2012

    • Author(s)
      Kanno M, Asahi K, Nakayama M, Watanabe T, et al.
    • Organizer
      Kidney Week 2012 (Annual Meeting of American Society of Nephrology)
    • Place of Presentation
      SanDiego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 食塩感受性高血圧ラットの腎髄質酸化ストレスに対するPioglitazoneの影響2012

    • Author(s)
      林義満、旭浩一、中山昌明、渡辺毅ら
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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