Pathogenic role of galactose-deficient IgA1 contained immune complexes and tonsillar cells in IgA nephropathy

• Project/Area Number: 24591213
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Juntendo University
• Principal Investigator: SUZUKI Hitoshi 順天堂大学, 医学部, 助教 (10468572)
• Research Collaborator: SUZUKI Yusuke 順天堂大学, 医学部, 准教授 ; YANAGAWA Hiroyuki 順天堂大学, 医学部 ; SASAKI Yohei 順天堂大学, 医学部
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IgA腎症 / 糖鎖 / 免疫複合体 / 粘膜免疫 / 扁桃 / 糖鎖異常IgA1

Outline of Final Research Achievements

Galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-specific autoantibodies have a crucial roles in the pathogenesis of IgA nephropathy (IgAN). Inflammatory cytokine, such as IL-6 and IL-4, could increase the production of Gd-IgA1 in IgA1-producing cell lines through complex changes of specific glycosyltransferases. Tonsillectomy plus corticosteroid therapy (TSP) is one of the effective therapies for IgAN. After TSP, serum levels of Gd-IgA1 and Gd-IgA1-specific autoantibodies significantly decreased. Thus, a part of Gd-IgA1 and Gd-IgA1-specific autoantibodies in circulation might be originated from palatine tonsil. Dysregulation of mucosal immunity may induce the overproduction of Gd-IgA1 and Gd-IgA1-specific autoantibodies via activation of TLR9 and APRIL.

Research Products

• [Journal Article] IgA腎症早期発見のための新規バイオマーカーを用いた血尿の2次スクリーニングの試み (2015)
  • Author(s): 鈴木 仁、鈴木祐介
  • Journal Title: 腎・高血圧の最新治療 Volume: 4 Pages: 28-33
• [Journal Article] A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases. (2014)
  • Author(s): Yanagawa H, Suzuki H, Suzuki Y, Kiryluk K, Gharavi AG, Matsuoka K, Makita Y, Julian BA, Novak J, Tomino Y.
  • Journal Title: PLoS One Volume: 23 Issue: 5 Pages: e98081-e98081
  • DOI: 10.1371/journal.pone.0098081
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proposal of remission criteria for IgA nephropathy. (2014)
  • Author(s): Suzuki Y, Matsuzaki K, Suzuki H, Sakamoto N, Joh K, Kawamura T, Tomino Y, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: 18 Issue: 3 Pages: 481-486
  • DOI: 10.1007/s10157-013-0849-x
  • NAID: 40019847882
  • Peer Reviewed / Open Access
• [Journal Article] Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy. (2014)
  • Author(s): Suzuki Y, Matsuzaki K, Suzuki H, Okazaki K, Yanagawa H, Ieiri N, Sato M, Sato T, Taguma Y, Matsuoka J, Horikoshi S, Novak J, Hotta O, Tomino Y.
  • Journal Title: Clin Exp Nephrol Volume: 18 Issue: 5 Pages: 770-777
  • DOI: 10.1007/s10157-013-0921-6
  • Peer Reviewed / Open Access
• [Journal Article] Dietary zinc is a key environmental modifier in the progression of IgA nephropathy. (2014)
  • Author(s): Maiguma M, Suzuki Y, Suzuki H, Okazaki K, Aizawa M, Muto M, Tomino Y
  • Journal Title: PLoS One Volume: 28 Issue: 2 Pages: e90558-e90558
  • DOI: 10.1371/journal.pone.0090558
  • Peer Reviewed
• [Journal Article] Changes in Nephritogenic Serum Galactose-Deficient IgA1 in IgA Nephropathy following Tonsillectomy and Steroid Therapy. (2014)
  • Author(s): Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Yanagawa H, Matsuzaki K, Horikoshi S, Novak J, Tomino Y.
  • Journal Title: PLoS One Volume: 21 Issue: 2 Pages: e89707-e89707
  • DOI: 10.1371/journal.pone.0089707
  • Peer Reviewed / Open Access
• [Journal Article] Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy. (2014)
  • Author(s): Aizawa M, Suzuki Y, Suzuki H, Pang H, Kihara M, Nakata J, Yamaji K, Horikoshi S, Tomino Y.
  • Journal Title: PLoS One Volume: 17 Issue: 4 Pages: e95365-e95365
  • DOI: 10.1371/journal.pone.0095365
  • Peer Reviewed / Open Access
• [Journal Article] Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy. (2014)
  • Author(s): Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
  • Journal Title: BMC Nephrology Volume: 15:89 Issue: 1 Pages: 89-89
  • DOI: 10.1186/1471-2369-15-89
  • Peer Reviewed / Open Access
• [Journal Article] Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. (2014)
  • Author(s): Kiryluk K, , Suzuki H, Wyatt RJ, Novak J, Julian BA, Feehally J, Lifton RP, Gharavi AG, et al.
  • Journal Title: Nat Genet Volume: 46 Issue: 11 Pages: 1187-1196
  • DOI: 10.1038/ng.3118
  • Peer Reviewed
• [Journal Article] Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. (2014)
  • Author(s): Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J.
  • Journal Title: J Biol Chem Volume: 21 Issue: 8 Pages: 5330-5339
  • DOI: 10.1074/jbc.m113.512277
  • Peer Reviewed
• [Journal Article] Diagnosis and activity assessment of immunoglobulin A nephropathy: current perspectives on noninvasive testing with aberrantly glycosylated immunoglobulin A-related biomarkers (2014)
  • Author(s): Suzuki Y, Suzuki H, Makita Y, Takahata A, Takahashi K, Muto M, Sasaki Y, Kelimu A, Matsuzaki K, Yanagawa H, Okazaki K, Tomino Y
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 7 Pages: 409-414
  • DOI: 10.2147/ijnrd.s50513
  • Peer Reviewed / Open Access
• [Journal Article] Development of Animal Models of Human IgA Nephropathy. (2014)
  • Author(s): Suzuki H, Suzuki Y, Novak J, Tomino Y
  • Journal Title: Drug Discov Today: Dis Model Volume: 11 Pages: 5-11
  • DOI: 10.1016/j.ddmod.2014.07.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The kinetics of glomerular deposition of nephritogenic IgA (2014)
  • Author(s): Yamaji K, Suzuki Y, Suzuki H, Satake K, Horikoshi S, Novak J, Tomino Y
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e113005-e113005
  • DOI: 10.1371/journal.pone.0113005
  • Peer Reviewed / Open Access
• [Journal Article] Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy (2014)
  • Author(s): Suzuki Y, Matsuzaki K, Suzuki H, Okazaki K, Yanagawa H, Ieiri N, Sato M, Sato T, Taguma Y, Matsuoka J, Horikoshi S, Novak J, Hotta O, Tomino Y.
  • Journal Title: Clin Exp Nephrol. Volume: 未定
  • Peer Reviewed
• [Journal Article] Experimental evidence of cell dissemination playing a role in pathogenesis of IgA nephropathy in multiple lymphoid organs. (2013)
  • Author(s): Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Horikoshi S, Novak J, Tomino Y
  • Journal Title: Nephrol Dial Transplant Volume: 28 Issue: 2 Pages: 320-326
  • DOI: 10.1093/ndt/gfs467
  • Peer Reviewed
• [Journal Article] Proposal of remission criteria for IgA nephropathy (2013)
  • Author(s): Suzuki Y, Matsuzaki K, Suzuki H, Sakamoto N, Joh K, Kawamura T, Tomino Y, Matsuo S
  • Journal Title: Clin Exp Nephrol Volume: 未定
  • NAID: 40019847882
  • Peer Reviewed
• [Journal Article] Biomarkers in IgA Nephropathy: Relationship to Pathogenetic Hits. (2013)
  • Author(s): Hastings MC, Moldoveanu Z, Suzuki H, Berthoux F, Julian BA, Sanders JT, Renfrow MB, Novak J, Wyatt RJ
  • Journal Title: Expert Opin Med Diagn Volume: 7 Issue: 6 Pages: 615-627
  • DOI: 10.1517/17530059.2013.856878
  • Peer Reviewed
• [Journal Article] Extraglomerular C3 deposition and metabolic impacts in patients with IgA nephropathy. (2013)
  • Author(s): Ohsawa I, Kusaba G, Ishii M, Sato N, Inoshita H, Onda K, Hashimoto A, Nagamachi S, Suzuki H, Shimamoto M, Ohi H, Horikoshi S, Tomino Y
  • Journal Title: Nephrol Dial Transplant Volume: 28 Issue: 7 Pages: 1856-1864
  • DOI: 10.1093/ndt/gfs262
  • Peer Reviewed
• [Journal Article] siRNAとshRNA (2013)
  • Author(s): 鈴木 仁
  • Journal Title: 腎臓病実験法ハンドブック Volume: 1 Pages: 83-85
• [Journal Article] Development of a model of early-onset IgA nephropathy. (2012)
  • Author(s): Okazaki K, Suzuki Y, Otsuji M, Suzuki H, Kihara M, Kajiyama T, Hashimoto A, Nishimura H, Brown R, Hall S, Novak J, Izui S, Hirose S, Tomino Y.
  • Journal Title: J Am Soc Nephrol Volume: 23 Issue: 8 Pages: 2930-2938
  • DOI: 10.1681/asn.2011121160
  • Peer Reviewed
• [Journal Article] Serum autoantibodies specific for galactose-deficient IgA1 associate with disease progression in IgA nephropathy. (2012)
  • Author(s): Berthoux F, Suzuki H, Thibaudin L, Yanagawa H, Maillard N, Mariat C, Tomino Y, Julian BA, Novak J
  • Journal Title: J Am Soc Nephrol Volume: 23 Issue: 9 Pages: 1579-1587
  • DOI: 10.1681/asn.2012010053
  • Peer Reviewed
• [Journal Article] Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes. (2012)
  • Author(s): Hashimoto A, Suzuki Y, Suzuki H, Ohsawa I, Brown R, Hall S, Tanaka Y, Novak J, Ohi H, Tomino Y
  • Journal Title: Am J Pathol Volume: 181 Issue: 4 Pages: 1338-1347
  • DOI: 10.1016/j.ajpath.2012.06.038
  • Peer Reviewed
• [Journal Article] Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. (2012)
  • Author(s): Kiryluk K, Li Y, Rohanizadegan M, Suzuki H, Eitner F, Narita I, Floege J, Stengel B, Zhang H, Lifton RP, Gharavi AG.
  • Journal Title: PLoS Genet Volume: 8 Issue: 6 Pages: e1002765-e1002765
  • DOI: 10.1371/journal.pgen.1002765
  • Peer Reviewed
• [Journal Article] Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice. (2012)
  • Author(s): Schoeb TR, Jarmi T, Hicks MJ, Henke S, Zarjou A, Suzuki H, Kramer P, Novak J, Agarwal A, Bullard DC
  • Journal Title: Arthritis Rheum Volume: 64 Issue: 12 Pages: 4114-4124
  • DOI: 10.1002/art.37683
  • Peer Reviewed
• [Journal Article] IgA腎症の病態における扁桃B細胞の役割および尿中糖鎖異常IgA1測定の有用性 (2012)
  • Author(s): 鈴木 仁、富野康日己
  • Journal Title: Annual Review 腎臓 2012 Volume: 1 Pages: 100-107
• [Journal Article] IgA分子の糖鎖異常と発症・進展における役割 (2012)
  • Author(s): 鈴木 仁、富野康日己
  • Journal Title: 腎と透析 Volume: 72 Pages: 36-38
• [Journal Article] Case IgA腎症 (2012)
  • Author(s): 鈴木 仁、富野康日己
  • Journal Title: 腎臓専門医のためのケースメソッドアプローチ Volume: 2 Pages: 38-44
• [Presentation] New insights into the pathogenesis of IgAN (2015)
  • Author(s): Hitoshi Suzuki
  • Organizer: 23rd The ISN World Congress of Nephrology
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-03-13 – 2015-03-17
  • Invited
• [Presentation] Pathogenic Role of Aberrantly-glycosylated IgA1 and Corresponding Autoantibodies in Patients with Henoch-Schoenlein Purpura Nephritis. (2014)
  • Author(s): Hitoshi Suzuki, Zina Moldoveanu, Bruce A. Julian, Yasuhiko Tomino, Robert J. Wyatt, Jan Novak.
  • Organizer: The ASN (American Society of Nephrology) 47th Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] An increase in the EPA/AA ratio is associated with reduction of proteinuria in CKD patients (2014)
  • Author(s): Hitoshi Suzuki, Chieko Nogi, Hiroaki Io, Yusuke Suzuki, Yasuhiko Tomino
  • Organizer: The ASN (American Society of Nephrology) 47th Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] Serum galactose-deficient IgA1 detected by specific monoclonal antibody KM55 is increased in IgA nephropathy patients (2014)
  • Author(s): Yusuke Suzuki, Hitoshi Suzuki, Junichi Yasutake, Yasuhiko Tomino
  • Organizer: The ASN (American Society of Nephrology) 47th Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] IgA腎症の病因における口蓋扁桃のAPRIL産生B細胞の役割 (2014)
  • Author(s): 武藤正浩、鈴木祐介、鈴木 仁、城 謙輔、井出章三、Bertral Juard、富野康日己
  • Organizer: 第57回日本腎臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] Novle diagnostic approach for IgA Nephropathy (2014)
  • Author(s): Suzuki H, Yanagawa H, Suzuki Y, Kiryluk K, Gharavi AG, Matsuoka K, Makita Y, Julian BA, Novak J, Tomino Y.
  • Organizer: The 14th Asian Pacific Congress of Nephrology
  • Place of Presentation: Tokyo
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] N-Acetylgalactosaminyltransferase-14 is Involved in IgA1 O-glycosylation. (2013)
  • Author(s): Jana Novakova, Tyler J. Stewart, Koshi Yamada, Hitoshi Suzuki, Zina Moldoveanu, Bruce A. Julian, Jan Novak, Milan Raska.
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Evidence that mucosal homing cells of patients with IgA nephropathy (IgAN) and healthy controls secrete polymeric J-chain-containing but differentially O-glycosylated IgA1. (2013)
  • Author(s): Hiroyuki Ueda, Zina Moldoveanu, Hitoshi Suzuki, Koshi Yamada, Bruce A. Julian, Jiri F. Mestecky and Jan Novak
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Assessment of Glomerular Changes in a Passive Mouse Model of IgA Nephropathy. (2013)
  • Author(s): Lea Novak, Zina Moldoveanu, Zhi Qiang Huang, Colleen J. Winstead, Stacy Hall, Rhubell Brown, Darrell B. O’Quinn, Bruce A. Julian, Casey T. Weaver, Jiri Mestecky, Hitoshi Suzuki, Jan Novak.
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Galactose-deficient IgA1 Production Enhanced by Abnormal Cytokine Signaling in IgA1-secreting Cells of Patients with IgA Nephropathy Can be Controlled by STAT Inhibitors. (2013)
  • Author(s): Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Joshua Anderson, Hitoshi Suzuki, Colin R. Reily, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Jiri Mestecky, Yasuhiko Tomino, Ali G. Gharavi, Bruce A. Julian, Christopher D. Willey, Jan Novak.
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Tonsillar Cells in Patients with IgA Nephropathy Produce Aberrantly Glycosylated IgA1 and Anti-glycan Antibodies. (2013)
  • Author(s): Hitoshi Suzuki, Yusuke Suzuki, Yuko Makita, Hiroyuki Yanagawa, Bruce A. Julian, Jan Novak, Yasuhiko Tomino.
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Cytokines Accentuate Synthesis of Galactose-deficient IgA1 in IgA Nephropathy by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes. (2013)
  • Author(s): Hitoshi Suzuki, Milan Raska, Koshi Yamada, Zina Moldoveanu, Bruce A. Julian, Robert J. Wyatt, Yasuhiko Tomino, Ali Gharavi, Jan Novak.
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Pathogenic role of IgA1-containing immune complexes in IgA nephropathy. (2013)
  • Author(s): Hitoshi Suzuki, Hiroyuki Yanagawa, Yusuke Suzuki, Kenji Satake, Bruce A. Julian, Jan Novak, Yasuhiko Tomino.
  • Organizer: The ASN (American Society of Nephrology) 46th Annual Meeting
  • Place of Presentation: Atlanta
• [Presentation] Influence of dietary condition in the susceptibility of IgA nephropathy. (2013)
  • Author(s): Maiguma M, Suzuki Y, Suzuki H, Okazaki K, Horikoshi S, Tomino Y.
  • Organizer: 13th International Symposium on IgA Nephropathy.
  • Place of Presentation: Nanjing
• [Presentation] Molecular Characterization of IgA1 secreted by IgA1-producing cell lines from patients with IgA nephropathy. (2013)
  • Author(s): Takahashi K, Suzuki H, Yamada K, Hall S, Moldoveanu Z, Poulson K, Kilian M, Mestecky J, Julian BA, Renfrow MB, Novak J.
  • Organizer: 13th International Symposium on IgA Nephropathy.
  • Place of Presentation: Nanjing
• [Presentation] Novel diagnostic approach for IgA nephropathy. 13th International Symposium on IgA Nephropathy. (2013)
  • Author(s): Yanagawa H, Suzuki H, Suzuki Y, Matsuoka J, Julian BA, Novak J, Tomino Y.
  • Organizer: 13th International Symposium on IgA Nephropathy.
  • Place of Presentation: Nanjing
• [Presentation] Potential Role of TLR in IgA Nephropathy. (2013)
  • Author(s): Hitoshi Suzuki
  • Organizer: 13th International Symposium on IgA Nephropathy.
  • Place of Presentation: Nanjing
  • Invited
• [Presentation] Tonsils of patients with IgA nephropathy contain cells producing aberrantly glycosylated IgA1 and anti-glycan antibodies: Implications for tonsillectomy. (2013)
  • Author(s): Hitoshi Suzuki, Yusuke Suzuki, Hiroyuki Yanagawa, Jan Novak, Yasuhiko Tomino.
  • Organizer: ISN World Congress of Nephrology
  • Place of Presentation: Hong Kong
• [Presentation] IgA腎症の寛解基準と腎予後の関係についての検討 (2013)
  • Author(s): 松崎慶一、鈴木祐介、坂本なほ子、清水芳男、鈴木仁、大澤勲、川村哲也、堀越哲、富野康日己
  • Organizer: 第110回日本内科学会
  • Place of Presentation: 東京
• [Presentation] 糖鎖不全IgA1の産生機序：サイトカインによる糖鎖修飾異常 (2013)
  • Author(s): 鈴木 仁、Milan Raska、鈴木祐介、山田耕嗣、Jan Novak、富野康日己
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
• [Presentation] IgA腎症 トランスレーショナルリサーチ－粘膜免疫異常の関与－ (2013)
  • Author(s): 鈴木 仁、鈴木祐介
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Cytokine-mediated Dysregulation of Specific Glycosyltransferases Contribute to Aberrant Glycosylation of IgA1 in Patients with IgA Nephropathy. (2012)
  • Author(s): Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] Tonsils of patients with IgA nephropathy contain cells producing aberrantly glycosylated IgA1 and anti-glycan antibodies: implications for tonsillectomy. (2012)
  • Author(s): Suzuki H, Suzuki Y, Yanagawa H, Novak J, Tomino Y
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] Novel diagnostic approach for IgA nephropathy. (2012)
  • Author(s): Yanagawa H, Suzuki H, Suzuki Y, Julian BA, Novak J, Tomino Y
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] Dietary Zn condition may determine susceptibility of IgA nephropathy. (2012)
  • Author(s): Maiguma M, Suzuki Y, Suzuki H, Okazaki K, Tomino Y
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] Characterization of signaling pathways that stimulate production of galactose-deficient IgA1 (Gd-IgA1) in tonsillar cells from patients with IgA nephropathy (IgAN). (2012)
  • Author(s): Yamada K, Suzuki H, Suzuki Y, Huang ZQ, Raska M, Moldoveanu Z, Julian BA, Tomino Y, Novak J
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] Molecular Characterization of IgA1 Secreted by IgA1-producing Cell Lines from Patients with IgA Nephropathy. (2012)
  • Author(s): Takahashi K, Suzuki H, Yamada K, Hall S, Moldoveanu Z, Poulsen K, Kilian M, Mestecky J, Julian BA, Renfrow MB, Novak J
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] A Passive Mouse Model that Displays Pathological Changes Typical for IgA Nephropathy (IgAN). (2012)
  • Author(s): Moldoveanu Z, Suzuki H, Satake K, Suzuki Y, Novak L, Huang ZQ, Winstead CJ, O’Quinn DB, Julian BA, Weaver C, Mestecky J, Tomino Y, Novak J
  • Organizer: The ASN (American Society of Nephrology) 45th Annual Meeting
  • Place of Presentation: San-Diego, USA
• [Presentation] IgA腎症の活動性評価における血中糖鎖不全IgA1とIgA-IgG免疫複合体測定の意義 (2012)
  • Author(s): 松崎慶一、鈴木祐介、鈴木 仁、岡崎圭子、柳川宏之、佐藤寿伸、堀越哲、堀田修、富野康日己
  • Organizer: 第109回日本内科学会
  • Place of Presentation: 京都
• [Presentation] IgA腎症の病態における糖鎖異常IgA1および糖鎖異常IgA1免疫複合体の役割 (2012)
  • Author(s): 鈴木 仁、佐竹健至、鈴木祐介、柳川宏之、富野 康日己
  • Organizer: 第55回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] IgA腎症患者における扁摘治療適応の科学的根拠 (2012)
  • Author(s): 鈴木 仁、鈴木祐介、柳川宏之、中田純一郎、佐藤大介、池田勝久、堀越 哲、Jan Novak、富野 康日己
  • Organizer: 第55回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] IgA腎症の新規非侵襲的診断法の確立 (2012)
  • Author(s): 柳川宏之、鈴木 仁、鈴木祐介、松岡 淨、松崎慶一、堀越 哲、Jan Novak、富野康日己
  • Organizer: 第55回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] IgA腎症患者における血清多量体IgAに限定したヒンジ部O-結合型糖鎖解析 (2012)
  • Author(s): 清水芳男、佐竹健至、麦谷 望、鈴木 仁、鈴木祐介、堀越 哲、富野康日己、本多伸一郎、渋谷和子、渋谷 彰
  • Organizer: 第55回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] IgA腎症の進展における亜鉛(Zn)の関与の可能性 (2012)
  • Author(s): 毎熊政行、鈴木祐介、鈴木 仁、堀越 哲、富野康日己
  • Organizer: 第55回日本腎臓学会
  • Place of Presentation: 横浜
• [Patent(Industrial Property Rights)] ＩｇＡ腎症検査法 (2015)
  • Inventor(s): 鈴木 仁
  • Industrial Property Rights Holder: 鈴木 仁
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-051874
  • Filing Date: 2015-03-16