The effects of mineral metabolism on the progression of DM nephropathy
| Project/Area Number |
24591215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URASHIMA Mituyoshi 東京慈恵会医科大学, 分子疫学研究部, 教授 (80203602)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ビタミンD / FGF23 / リン / 糖尿病 / インスリン抵抗性 / リン代謝 / 糖尿病腎症 / resistin / CKD-MBD / Vitamin D / Carbohydrate Metabolism / carbohydrate metabolism / 糖尿病性腎症 / ビタミンD受容体遺伝子 |
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| Outline of Final Research Achievements |
We evaluated the association between factors concerning mineral metabolism and those concerning diabetes by using cohorts of HD patients (1280 cases) and DM patients (408 cases). We found the influences of vitamin D on the progression of DM nephropathy and also found the effects of SNP（FokⅠVDR）and Copy Number Variation （CNV；UGT2B17）on the progression of DM nephropathy.Serum levels of FGF23, which suppress vitamin D activation showed a positive correlation with resistin concerning insulin resistance.
Depending on our results, we hypothesize that mineral metabolism effects the progression of DM nephropathy.
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Report
(5 results)
Research Products
(27 results)
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[Presentation] リン吸着薬
Author(s)
横山啓太郎
Organizer
第57回日本透析医学会
Place of Presentation
福岡
Related Report
Invited
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