The effects of mineral metabolism on the progression of DM nephropathy

• Project/Area Number: 24591215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: YOKOYAMA KEITARO 東京慈恵会医科大学, 医学部, 准教授 (70211654)
• Co-Investigator(Kenkyū-buntansha): URASHIMA Mituyoshi 東京慈恵会医科大学, 分子疫学研究部, 教授 (80203602)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ビタミンD / FGF23 / リン / 糖尿病 / インスリン抵抗性 / リン代謝 / 糖尿病腎症 / resistin / CKD-MBD / Vitamin D / Carbohydrate Metabolism / carbohydrate metabolism / 糖尿病性腎症 / ビタミンD受容体遺伝子

Outline of Final Research Achievements

We evaluated the association between factors concerning mineral metabolism and those concerning diabetes by using cohorts of HD patients (1280 cases) and DM patients (408 cases). We found the influences of vitamin D on the progression of DM nephropathy and also found the effects of SNP（FokⅠVDR）and Copy Number Variation （CNV；UGT2B17）on the progression of DM nephropathy.Serum levels of FGF23, which suppress vitamin D activation showed a positive correlation with resistin concerning insulin resistance.
Depending on our results, we hypothesize that mineral metabolism effects the progression of DM nephropathy.

Research Products

• [Journal Article] Frequent monitoring of mineral metabolism in hemodialysis patients with secondary hyperparathyroidism: associations with achievement of treatment goals and with adjustments in therapy. (2016)
  • Author(s): Yokoyama K, Kurita N, Fukuma S, Akizawa T, Fukagawa M, Onishi Y, Kurokawa K, Fukuhara S.
  • Journal Title: Nephrol Dial Transplant. Volume: in press Pages: gfw020-gfw020
  • DOI: 10.1093/ndt/gfw020
  • Peer Reviewed / Open Access
• [Journal Article] The value of ferric citrate, an iron-containing phosphate binder, might be different between Japan and the United States. (2015)
  • Author(s): Yokoyama K, Maruyama Y, Ohkido I, Yokoo T.
  • Journal Title: Kidney Int. Volume: 87 Issue: 5 Pages: 1074-1075
  • DOI: 10.1038/ki.2015.45
  • Peer Reviewed / Open Access
• [Journal Article] Does bone structure accurately reflect serum FGF23 levels in patients with chronic kidney disease? (2015)
  • Author(s): Yokoyama K, Nakashima A, Maruyama Y, Ohkido I, Yokoo T.
  • Journal Title: Kidney Int. Volume: 88 Issue: 3 Pages: 640-640
  • DOI: 10.1038/ki.2015.206
  • Peer Reviewed / Open Access
• [Journal Article] Long-term safety and efficacy of a novel iron-containing phosphate binder, JTT-751, in patients receiving hemodialysis． (2014)
  • Author(s): Yokoyama K, Akiba T, Fukagawa M, Nakayama M, Sawada K, Kumagai Y, Chertow GM, Hirakata H
  • Journal Title: Journal of Renal Nutrition Volume: 24 Issue: 4 Pages: 261-267
  • DOI: 10.1053/j.jrn.2014.03.006
  • Peer Reviewed
• [Journal Article] Chest X-ray may serve as a screening examination for coronary artery calcification in dialysis patients． (2014)
  • Author(s): Watanabe K, Yokoyama K, Yoshida H, Tanno Y, Ohkido I, Yokoo T
  • Journal Title: Kidney Internatinal Volume: 85 Issue: 3 Pages: 710-710
  • DOI: 10.1038/ki.2013.509
  • Peer Reviewed
• [Journal Article] A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan. (2014)
  • Author(s): Maruyama Y, Taniguchi M, Kazama JJ, Yokoyama K, Hosoya T, Yokoo T, Shigematsu T, Iseki K, Tsubakihara Y.
  • Journal Title: Nephrol Dial Transplant. Volume: Epub ahead of print Issue: 8 Pages: 1-6
  • DOI: 10.1093/ndt/gfu055
  • Peer Reviewed
• [Journal Article] JTT-751 for treatment of patients with hyperphosphatemia on peritoneal dialysis. (2014)
  • Author(s): Yokoyama K, Akiba T, Fukagawa M, Nakayama M, Hirakata H.
  • Journal Title: Nephron Clin Pract. Volume: 128 Issue: 1-2 Pages: 135-40
  • DOI: 10.1159/000366482
  • Peer Reviewed
• [Journal Article] A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis. (2014)
  • Author(s): Yokoyama K, Akiba T, Fukagawa M, Nakayama M, Sawada K, Kumagai Y, Chertow GM, Hirakata H.
  • Journal Title: Nephrol Dial Transplant. Volume: 29 Issue: 5 Pages: 1053-60
  • DOI: 10.1093/ndt/gft483
  • Peer Reviewed
• [Journal Article] Ferric citrate hydrate for the treatment of hyperphosphatemia in nondialysis-dependent CKD. (2014)
  • Author(s): Yokoyama K, Hirakata H, Akiba T, Fukagawa M, Nakayama M, Sawada K, Kumagai Y, Block GA.
  • Journal Title: Clin J Am Soc Nephrol. Volume: 9 Issue: 3 Pages: 543-52
  • DOI: 10.2215/cjn.05170513
  • Peer Reviewed
• [Journal Article] Chest X-ray may serve as a screening examination for coronary artery calcification in dialysis patients. (2014)
  • Author(s): Watanabe K, Yokoyama K, Yoshida H, Tanno Y, Ohkido I, Yokoo T.
  • Journal Title: Kidney Int. Volume: 85 Pages: 710-710
  • Peer Reviewed
• [Journal Article] Kidney Int. (2013)
  • Author(s): Yokoyama K, Taniguchi M, Fukagawa M
  • Journal Title: Kidney Int. Volume: Supplements 3 Pages: 451-456
  • Peer Reviewed
• [Journal Article] Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes (2012)
  • Author(s): Yokoyama K, Nakashima A, Urashima M, Utsunomiya K, Hosoya T.
  • Journal Title: PLoS One. Volume: 7
  • Peer Reviewed
• [Journal Article] Effect of oral JTT-751 (ferric citrate) on hyperphosphatemia in hemodialysis patients: results of a randomized, double-blind, placebo-controlled trial. (2012)
  • Author(s): Yokoyama K, Hirakata H, Akiba T, Sawada K, Kumagai Y.
  • Journal Title: Am J Nephrol Volume: 36 Issue: 5 Pages: 478-87
  • DOI: 10.1159/000344008
  • Peer Reviewed
• [Journal Article] Guidelines and medication compliance. (2012)
  • Author(s): Yokoyama K, Tanno Y, Ohkido I, Hosoya T.
  • Journal Title: Kidney Int. Volume: 81 Pages: 595-595
  • Peer Reviewed
• [Journal Article] Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. (2012)
  • Author(s): Yokoyama K, Ohkido I, Iwamoto T, Ishida M, Urashima M, Hosoya T.
  • Journal Title: Clin Nephrol. Volume: 78 Pages: 85-6
  • Peer Reviewed
• [Journal Article] Cinacalcet for hemodialyzed patients with or without a high PTH level to control serum calcium and phosphorus: ECO (evaluation of cinacalcet HCl outcome) study. (2012)
  • Author(s): Yokoyama K, Ohkido I, Ishida M, Hashimoto H, Urae J, Sekino H
  • Journal Title: Clin Nephrol. Volume: 78 Pages: 87-93
  • Peer Reviewed
• [Journal Article] Proton Pump Inhibitor Use and Magnesium Concentrations in Hemodialysis Patients: A Cross-Sectional Study.
  • Author(s): Nakashima A, Ohkido I, Yokoyama K, Mafune A, Urashima M, Yokoo T.
  • Journal Title: PLoS One. Volume: 10 Issue: 11 Pages: e0143656-e0143656
  • DOI: 10.1371/journal.pone.0143656
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Decreasing ESA dosage can be a factor of the increase in ferritin under the administration of ferric citrate with improving ESA resistance index. (2015)
  • Author(s): Yokoyama K, Akiba T, Fukagawa M, Nakayama M, Hirakata H.
  • Organizer: ASN Kidney Week - 2015
  • Place of Presentation: SanDiego U.S.A
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] 包括的なリン管理の実際 (2015)
  • Author(s): 横山啓太郎
  • Organizer: 第60回日本透析医学会学術集会・総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] Paradigm Shift for CKD-MBD (2015)
  • Author(s): Yokoyama K
  • Organizer: 16th Asian Nephrology conference
  • Place of Presentation: Kaohsiung Taiwan
  • Year and Date: 2015-04-24
  • Int'l Joint Research / Invited
• [Presentation] 保存期慢性腎臓病患者のリン管理． (2014)
  • Author(s): 横山啓太郎
  • Organizer: 第44回日本腎臓学会東部学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-24 – 2014-10-25
  • Invited
• [Presentation] 慢性腎臓病における骨・ミネラル代謝異常 (2014)
  • Author(s): 横山啓太郎
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-07-04 – 2014-07-06
  • Invited
• [Presentation] Clinical Practice Guideline for CKD-MBD (2013)
  • Author(s): Yokoyama K.
  • Organizer: The 7th China-Korea-Japan Nephrology Conference2013 March
  • Place of Presentation: Soul. Korea
  • Invited
• [Presentation] Differential Associations of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D with Impaired Renal Function in Patients with Diabetes (2012)
  • Author(s): Yokoyama K, Nakashima A, Urashima M, Ohkido I, Hosoya T.
  • Organizer: 45th Annual Meeting of American Society of Nephrology.
  • Place of Presentation: SanDiego. U.S.A.
• [Presentation] The Effect of JTT-751 (Ferric Citrate Hydrate) on Phosphorus and FGF-23 in Chronic Kidney Disease
  • Author(s): Yokoyama K, Hirakata H, Akiba T, Fukagawa M, Nakayama M, Sawada K, Kumagai Y, Block GA.
  • Organizer: 46th Annual Meeting of American Society of Nephrology.
  • Place of Presentation: Atlanta, GA
• [Presentation] リン吸着薬
  • Author(s): 横山啓太郎
  • Organizer: 第57回日本透析医学会
  • Place of Presentation: 福岡
  • Invited
• [Book] ビタミンDは長寿の薬か (2013)
  • Author(s): CKD-MBD診療ポケットガイド
  • Publisher: 南江堂