Development of metabolomic biomarkers for early detection of acute kidney injury in kidney transplantation.
| Project/Area Number |
24591219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Shin'ichi 名古屋大学, 医学(系)研究科(研究院), 講師 (20500010)
HAYASHI Hiroki 藤田保健衛生大学, 医学部, 助教 (10378086)
HASEGAWA Midori 藤田保健衛生大学, 医学部, 教授 (40298518)
KUSAKA Mamoru 藤田保健衛生大学, 医学部, 教授 (40309141)
MARUYAMA Shoichi 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253)
SATO Waichi 藤田保健衛生大学, 医学部, 准教授 (90508920)
SOGA Tomoyoshi 慶応義塾大学, 環境情報学部, 教授 (60228217)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | AKIバイオマーカー / メタボローム解析 / 腎移植 / AKI: acute kidney injury / 急性腎傷害 |
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| Outline of Final Research Achievements |
We have established the level of urinary midkine as an early biomarker of acute kidney injury (AKI). Furthermore, recent advances on metabolomics allowed us to identify metabolomic biomarkers for prediction of AKI. This study aimed to develop metabolomics biomarkers for early detection of AKI after renal transplantation by elucidating the detailed molecular mechanism of AKI at the metabolite level. A simultaneous metabolomics analysis with capillary electrophoresis-time of flight-mass spectrometry was conducted on urine samples from subjects who had undergone the surgery with renal ischemia reperfusion at the time of renal transplantation. Our metabolomic profiling identified novel biomarker candidates for early prediction of ischemic AKI in kidney transplantation.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Long-term effects of spironolactone in peritoneal dialysis patients.2014
Author(s)
Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
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Journal Title
J Am Soc Nephrol
Volume: 25(5)
Pages: 1094-102
DOI
Related Report
Peer Reviewed
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[Journal Article] Enzymatic sialylation of IgA1 o-glycans: implications for studies of IgA nephropathy.2014
Author(s)
Takahashi K, Raska M, Stuchlova Horynova M, Hall SD, Poulsen K, Kilian M, Hiki Y, Yuzawa Y, Moldoveanu Z, Julian BA, Renfrow MB, Novak J.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis.2013
Author(s)
Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K
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Journal Title
Am J Pathol.
Volume: 182(2)
Pages: 410-419
DOI
Related Report
Peer Reviewed
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[Journal Article] CD147/basigin reflects renal dysfunction in patients with acute kidney injury.2013
Author(s)
Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S
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Journal Title
Clin Exp Nephrol.
Volume: 999
Pages: 999-999
Related Report
Peer Reviewed
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[Presentation] IgA Antibodies to Glomerular Endothelial Cells in Patients with Lupus Nephritis: Correlations with Renal Injury.2013
Author(s)
Kazuo Takahashi, Ayako Kondo, Daisuke Hirano, Shin’ichi Akiyama, Hiroki Hayashi, Shigehisa Koide, Midori Hasegawa, Yoshiyuki Hiki, Shunji Yoshida, Keiji Miura, Yukio Yuzawa
Organizer
Kidney Week 2013 (American Society of Nephrology)
Place of Presentation
Atlanta,Georgia,USA
Related Report
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[Presentation] Distant Effects of AKI on Lung Injuries by Soluble Mediators in Broncho-Alveolar Lavage Fluid in Patients with Acute Lung Injury / Acute Respiratory Distress Syndrome.2012
Author(s)
Hiroki Hayashi, Sachiyo Suzuki, Kensuke Kataoka, Yasuhiro Kondoh, Hiroyuki Taniguchi, Daisuke Sugiyama, Kunihiro Nishimura, Waichi Sato, Shoichi Maruyama, Seiichi Matsuo, Yukio Yuzawa
Organizer
ERA-EDTA Congress 2012
Place of Presentation
Paris, France
Related Report
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