Immune reaction observed in IgG4-related kidney disease
Project/Area Number |
24591221
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Fukuoka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MIYAKE Katsuhisa 福岡大学, 医学部, 講師 (50448411)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | IgG4関連腎臓病 / Th2反応 / 制御性T細胞 / 寄生虫感染 / Th2 / マンソン吸虫 / 動脈周囲炎 / Th1/Th2バランス / ループス腎炎 / Th1/Th2 バランス |
Outline of Final Research Achievements |
Based on the cytokine production results from biopsied kidney tissues, Th2 and Treg appear to play a central role in IgG4-related kidney disease (IgG4-RKD). The expression pattern of cytokine mRNA observed in IgG4-RKD was similar with that seen in chronic helminth infected patients. It has been revealed that this immune reaction suppresses allergic Th2 response, and has been called a ‘modified Th2 response’. Pathological analysis using dissected kidney organ indicated that IgG4-RKD showed periarteritis. Then we infected vasculitis model animal, MRL/lpr mice, with schistosoma mansonie and performed histlogical analysis. The histological findings in kidney from infected mice were significantly different from those in uninfected mice, and showed periarteritis like human IgG4-RKD. It was indicated that helminth infection induced Th2 and Treg predominant immunity, and which may alter vasculitis phenotype in MRL/lpr mice.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Parasites alter the pathological phenotype of lupus nephritis.2014
Author(s)
Miyake K, Adachi K, Watanebe M, Sasatomi Y, Ogahara S, Abe Y, Ito K, Justin YKD, Saito T, Nakashima H, Hamano S
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Journal Title
Autoimmunity
Volume: 47
Issue: 8
Pages: 538-547
DOI
Related Report
Peer Reviewed
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[Journal Article] Remission in patients with active rheumatoid arthritis by tocilizumab treatment in routine clinical practice: results from 3 years of prospectively registered data.2014
Author(s)
Nakashima Y, Kondo M, Fukuda T, Harada H, Horiuchi T, Ishinishi T, Jojima H, Kuroda K, Miyahara H, Maekawa M, Nishizaka H, Nagamine R, Nakashima H, Otsuka T, Shono E, Suematsu E, Shimauchi T, Tsuru T, Wada K, Yoshizawa S, Yoshizawa S, Iwamoto Y.
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Journal Title
Mod Rheumatol
Volume: 24
Issue: 2
Pages: 258-264
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical characteristics of Mikulicz's disease as an IgG4-related disease.2013
Author(s)
Moriyama M, Tanaka A, Maehara T, Ohyama Y, Shimizu M, Nakashima H, Hayashida J, Shinozaki S, Kubo Y, Furukawa S, Kikuta T, Nakamura S
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Journal Title
Clin Oral Invest.
Volume: 17
Pages: 1995-2002
Related Report
Peer Reviewed
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[Journal Article] The efficacy of incretin therapy in patient with type 2 diabetes undergoing hemodialysis.2013
Author(s)
Terawaki Y, Nomiyama T, Akehi Y, Takenoshita H, Nagaishi R, Tsutsumi Y, Murase K, Nagasako H, Hamanoue N, Sugimoto K, Takada A, Ito K, Abe Y, Sasatomi Y, Ogahara S, Nakashima H, Saito T, Yanase T
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Journal Title
Diabetology & Metabolic Syndrome
Volume: 5
Pages: 10-12
Related Report
Peer Reviewed
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[Journal Article] The different role of Th cytokine mRNA expressions across different forms of glomerulonephritis.2013
Author(s)
Ifuku M, Miyake K, Watanebe M, Ito K, Abe Y, Sasatomi Y, Ogahara S, Hisano S, Sato H, Saito T, Nakashima H;
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Journal Title
Am J Nephrol.
Volume: 38
Issue: 2
Pages: 115-123
DOI
Related Report
Peer Reviewed
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[Journal Article] The clinical course of patients with IgG4-related kidney disease.2013
Author(s)
Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, Homma N, Tsubata Y, Takahashi H, Ito T, Yamazaki H, Saito T, Narita I:
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Journal Title
Kidney Int.
Volume: 84
Pages: 826-833
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical characteristics of IgG4-related tubulointerstitial nephritis: Detailed analysis of 20 Japanese cases.2012
Author(s)
Kawano M, Mizushima I, Yamaguchi Y, Imai N, Nakashima H, Nishi S, Hisano S, Yamanaka N, Yamamoto M, Takahashi H, Umehara H, Saito T, Saeki T;
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Journal Title
Int J Rheumatol.
Volume: Article ID 609795
Pages: 1155-1155
Related Report
Peer Reviewed
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[Journal Article] Clinical characteristics of Mikulicz's disease as an IgG4-related disease.2012
Author(s)
Moriyama M, Tanaka A, Maehara T, Ohyama Y, Shimizu M, Nakashima H, Hayashida J, Shinozaki S, Kubo Y, Furukawa S, Kikuta T, Nakamura S
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Journal Title
Clin Oral Invest.
Volume: 0905
Pages: 1007-1007
Related Report
Peer Reviewed
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