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The role of Mafb in secondary hyperparathyroidism.

Research Project

Project/Area Number 24591223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

MORITO Naoki  筑波大学, 医学医療系, 講師 (70463825)

Co-Investigator(Kenkyū-buntansha) YOH Keigyou  筑波大学, 医学医療系, 准教授 (90323302)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords2次性副甲状腺機能亢進症 / 二次性副甲状腺機能亢進症 / 転写因子 / 慢性腎臓病 / CKD-MBD
Outline of Final Research Achievements

Secondary hyperparathyroidism (HPT) is a common disorder in patients with chronic kidney disease (CKD). Recently, it was reported that the transcription factor Mafb is essential for differentiation of parathyroid gland. However, the role of Mafb in secondary hyperparathyroidism is not well known. Six-week-old WT (wild-type) and Mafb+/- mice were fed with adenine containing or normal diet. After 6 weeks of feeding, secondary hyperparathyroidism was assessed. Interestingly, secondary HPT was prevented in Mafb+/- mice. Mafb+/- mice had lower serum PTH levels and smaller parathyroid gland areas compared to their WT littermates after adenine feeding. Moreover, we found lower PTH and cyclinD2 expression in Mafb+/- parathyroid glands. These facts suggest that Mafb directly regulates the PTH and cyclinD2 expression in parathyroid glands.Mafb might play an important role in secondary HPT through PTH and cyclinD2 transcription.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 1 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] Overexpression of Mafb in podocytes protects against diabetic nephropathy.2014

    • Author(s)
      Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 25 Pages: 2546-2557

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Overexpression of Mafb in Podocytes Protects against Diabetic Nephropathy.2014

    • Author(s)
      Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T, Yamagata K, Takahashi S.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 印刷中 Issue: 11 Pages: 2546-2557

    • DOI

      10.1681/asn.2013090993

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA32014

    • Author(s)
      Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, Engel JD, Yamamoto M
    • Journal Title

      Molecular and Cellular Biology

      Volume: 8 Issue: 11 Pages: 1929-1941

    • DOI

      10.1128/mcb.01659-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] O-Linked Glycosylation Determines the Nephritogenic Potential of IgA Rheumatoid Factor.2014

    • Author(s)
      Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S.
    • Journal Title

      J Am Soc Nephrol.

      Volume: Feb 7. [Epub ahead of print] Issue: 6 Pages: 1-9

    • DOI

      10.1681/asn.2013070771

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of irbesartan on inflammatory cytokine concentrations in patients with chronic glomerulonephritis.2013

    • Author(s)
      Tsuruoka S, Kai H, Usui J, Morito N, Saito C, Yoh K, Yamagata K.
    • Journal Title

      Intern Med.

      Volume: 52 Pages: 303-308

    • NAID

      130003365884

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amelioration of cisplatin- induced nephrotoxicity in Peroxiredoxin I- deficient mice.2012

    • Author(s)
      Kosuke Okada
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71 Issue: 2 Pages: 503-509

    • DOI

      10.1007/s00280-012-2046-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation2012

    • Author(s)
      Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
    • Journal Title

      Free Radic Biol Med

      Volume: 53 Issue: 12 Pages: 2256-2262

    • DOI

      10.1016/j.freeradbiomed.2012.10.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice2012

    • Author(s)
      Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S
    • Journal Title

      Eur J Immunol

      Volume: 42 Issue: 8 Pages: 1999-2009

    • DOI

      10.1002/eji.201142250

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The Role of Mafb in secondary hyperparathyroidism due to chronic kidney disease.2014

    • Author(s)
      Naoki Morito, Keigyou Yoh, Akiko Fujita, Kunihiro Yamagata
    • Organizer
      51st ERA-EDTA Congress,
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2014-05-31 – 2014-06-03
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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