| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Secondary hyperparathyroidism (HPT) is a common disorder in patients with chronic kidney disease (CKD). Recently, it was reported that the transcription factor Mafb is essential for differentiation of parathyroid gland. However, the role of Mafb in secondary hyperparathyroidism is not well known. Six-week-old WT (wild-type) and Mafb+/- mice were fed with adenine containing or normal diet. After 6 weeks of feeding, secondary hyperparathyroidism was assessed. Interestingly, secondary HPT was prevented in Mafb+/- mice. Mafb+/- mice had lower serum PTH levels and smaller parathyroid gland areas compared to their WT littermates after adenine feeding. Moreover, we found lower PTH and cyclinD2 expression in Mafb+/- parathyroid glands. These facts suggest that Mafb directly regulates the PTH and cyclinD2 expression in parathyroid glands.Mafb might play an important role in secondary HPT through PTH and cyclinD2 transcription.
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