Development of functional redox nanoparticle for long-term peritoneal dialysis

• Project/Area Number: 24591224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tsukuba University of Technology
• Principal Investigator: AKI HIRAYAMA 筑波技術大学, 保健科学部, 教授 (20323298)
• Co-Investigator(Kenkyū-buntansha): YOSHITOMI Toru 筑波大学, 数理物質科学研究科(系), 研究員 (20585799) ; NAGASAKI Yukio 筑波大学, 数理物質科学研究科(系), 教授 (90198309)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ナノメディシン / 酸化ストレス / 腹膜透析 / 慢性腎臓病 / ナノ粒子 / 硬化性被嚢性腹膜炎

Outline of Final Research Achievements

Encapsulating peritoneal sclerosis (EPS) is a major cause that prevent long-term peritoneal dialysis leading to a loss of quality of life in patients. In this study, we developed bionanoparticle which prevented peritoneal inflammation by its internal antioxidant and enhanced absorption of low molecular-weight uremic toxins by its contained silica. The developed nanoparticle: silica-contained redox nanoparticle (SiRNP), effectively suppressed the peritoneal thickness in EPS model when it was contained to peritoneal dialysate. In addition, SiRNP decreased blood urea nitrogen and serum creatinine levels in renal failure model.

Research Products

• [Journal Article] Design and use of silica-containing redox nanoparticles, siRNP for high-performance peritoneal dialysis (2014)
  • Author(s): Yukio Nagasaki, Tatsuya Yaguchi, Takuma Matsumura, Toru Yoshitomi, Yutaka Ikeda, Atsushi Ueda, and Aki Hirayama
  • Journal Title: Biomaterials Science Volume: 2 Issue: 4 Pages: 522-529
  • DOI: 10.1039/c3bm60236b
  • Peer Reviewed / Open Access
• [Journal Article] ROS-scavenging Nanomedicine for Treatment of Oxidative Stress Injuries (2014)
  • Author(s): Toru Yoshitomi, Yukio Nagasaki
  • Journal Title: Advanced Healthcare Materials Volume: 3 Issue: 8 Pages: 1149-1161
  • DOI: 10.1002/adhm.201300576
  • Peer Reviewed
• [Journal Article] Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation. (2013)
  • Author(s): Pua ML, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y
  • Journal Title: J Control Release Volume: 172 Issue: 3 Pages: 914-920
  • DOI: 10.1016/j.jconrel.2013.10.009
  • Peer Reviewed
• [Journal Article] Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation (2012)
  • Author(s): Nagano Y, Matsui H, Shimokawa O, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 3 Pages: 196-203
  • DOI: 10.3164/jcbn.12-41
  • NAID: 130004466701
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Presentation] Design of redox polymer-silica nanohybrid materials for effective treatment of renal failure. (2014)
  • Author(s): Matsumura T, Yaguchi T, Yoshitomi T, Ikeda Y, Ueda A, Hirayama A, Nagasaki Y
  • Organizer: SPSJ International Polymer Conferences 2014
  • Place of Presentation: EPHOCAL Tsukuba (Tsukuba, Ibaraki, Japan)
  • Year and Date: 2014-12-02 – 2014-12-04
• [Presentation] Nano-kidney possessing oxidative stress suppression character. (2014)
  • Author(s): Nagasaki Y, Yaguchi T, Matsumura T, Yoshitomi T, Ikeda Y, Ueda A, Hirayama A.
  • Organizer: ASN Kidney Week 2014, 2014 Annual Meeting of the American Society of Nephrology.
  • Place of Presentation: Philadelphia, PA (USA)
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] Design of Nanoparticle therapeutics for ischemia reperfusion injuries. (2014)
  • Author(s): Nagasaki Y, Yoshitomi T, Toh K, Marushima A, Tsurushima H, Suzuki K, Matsumura A, Hirayama A, Sanada S, Yoshida A, Kitakaze M.
  • Organizer: 2nd International Meeting on Ischemia Reperfusion Injury in Transplantation.
  • Place of Presentation: Poitiers (France)
  • Year and Date: 2014-04-25
• [Presentation] Preparation and evaluation of silica-containing redox nanoparticle for peritoneal dialysis which aimed at the medical treatment of chronic renal failure (2013)
  • Author(s): Matsumura T, Yaguchi T, Amraon Md, Ikeda Y, Yoshitomi T, Hirayama A, Ueda A, Nagasaki Y
  • Organizer: Tsukuba International Conference on Materials Science
  • Place of Presentation: Tsukuba International Congress Center, Tsukuba
• [Presentation] シリカゲル含有レドックスナノ粒子の作製と評価 (2013)
  • Author(s): 吉冨 徹
  • Organizer: 第24回高分子ゲル研究討論会
  • Place of Presentation: 東京，東京大学他
• [Presentation] Uremic toxin indoxyl sulfate induce mitochondrial superoxide leakage. (2012)
  • Author(s): Hirayama A
  • Organizer: 19th Annual Meeting of the Society for Free Radical Biology and Medicine
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Combination Therapy with Peritoneal Dialysis and Hemodialysis from the Initiation of Renal Replacement Therapy Preserve the Residual Renal Function and Improve the Patients’ Prognosis. (2012)
  • Author(s): Ueda A
  • Organizer: 14th Congress of the International Society for Peritoneal Dialysis, International Society for Peritoneal Dialysis.
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Nanotechnology in, vivo: Redox Polymer Therapeutics
  • Author(s): Nagasaki Y
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii, U.S.A
  • Invited
• [Presentation] Novel redox polymer therapeutics for antioxidative injuries
  • Author(s): Nagasaki Y
  • Organizer: 17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014)
  • Place of Presentation: Kyoto International Conference Center, Sakyo-ku, Kyoto
  • Invited
• [Presentation] 高性能な腹膜透析液の開発を目指したシ リカ含有レドックスナノ粒子の作製と評価
  • Author(s): 松村卓馬、矢口達也、池田 豊 、吉 冨 徹、平山 暁、植田敦志 ,植田敦志 、長崎 幸夫
  • Organizer: 第23回日本MRS年次大会
  • Place of Presentation: 横浜開港記念会館，横浜情報文化センター，波止場会館，万国橋会議センター，横浜
• [Presentation] 抗炎症性と 老廃物吸着能を併せ持つシリカ含有レドック スナノ粒子の設計腹膜透析へ展開
  • Author(s): 松村卓馬, 矢口達也,池田 豊, 吉冨 徹,植田敦志,平山 暁,長崎幸夫
  • Organizer: つくば医 工連携フォーラム2014
  • Place of Presentation: つくば国際会議場，つくば
• [Presentation] Upper Stream Reactions of Oxidative Stress in Hemodialysis Patients.
  • Author(s): Hirayama A, Ueda A, Nagase S, Matsui H, Aoyagi K, Owada S.
  • Organizer: 2013 Annual meeting of the American Society of Nephrology (Kidney Week 2013)
  • Place of Presentation: Georgia World Congress Center, Atlanta, GA, USA
• [Remarks] Research Gate
  • URL: https://www.researchgate.net/publication/266858164_Design_and_use_of_silica-containing_redox_nanoparticles_siRNPs_for_high-performance_peritoneal_dialysis
• [Patent(Industrial Property Rights)] 高分子環状ニトロキシドラジカル化合物とシリカの有機―無機ハイブリッド複合体 (2013)
  • Inventor(s): 長崎幸夫，吉冨 徹，平山 暁他
  • Industrial Property Rights Holder: 長崎幸夫，池田 豊，吉冨 徹，植田敦志，平山 暁，他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-06
  • Overseas