Studies of complement-related mechanisms and possibilities of anti-complement therapy for peritoneal injuries under PD therapy

• Project/Area Number: 24591227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: MASASHI Mizuno 名古屋大学, 医学(系)研究科(研究院), 寄附講座准教授 (20303638)
• Co-Investigator(Kenkyū-buntansha): ITO Yasuhiko 名古屋大学, 大学院医学系研究科, 寄附講座教授 (60402632) ; SUZUKI Yasuhiro 名古屋大学, 大学院医学系研究科, 寄附講座助教 (20584676) ; MATSUO Seiichi 名古屋大学, 大学院医学系研究科, 教授 (70190410)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 人工透析学 / 腹膜透析 / 補体活性化 / 補体制御 / 腹膜障害 / 内科 / 人工腎臓

Outline of Final Research Achievements

We clarified that plenty of CReg, CD46, CD55 and CD59 were expressed in mesothelial cell of human peritoneum. When we investigated whether performance of PD therapy influenced the complement system in PD patients, we got correlation between levels of sC5b-9 in PD fluid and D/P creatinine and reverse-correlation between D/P creatinine and expression of CD55 in peritoneal mesothelium in the PD patients. Between serum levels and PD fluids, C4 was well correlated but not C3. Our results suggested that PD therapy might change CD55 expression of mesothelium and influence D/P creatinine in the PD patient dependent on activation of the alternative pathway presumably.
Using an acute peritonitis model on rat, we showed the supportive data of the possibilities of anti-complement therapies because suppression of C5a could improve the acute peritoneal injuries.

Research Products

• [Journal Article] Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy. (2015)
  • Author(s): Sei Y, Mizuno M, Suzuki Y, Imai M, Higashide K, Harris CL, Sakata F, Iguchi D, Fujiwara M, Kodera Y, Maruyama S, Matsuo S, Ito Y
  • Journal Title: Molecular Immunology Volume: 153 Issue: 2 Pages: 302-309
  • DOI: 10.1016/j.molimm.2015.02.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Calcified Amorphous Tumor in the Left Atrium in a Patient on Long-term Peritoneal Dialysis (2015)
  • Author(s): Tanaka A, Mizuno M, Suzuki Y, Oshima H, Sakata F, Ishikawa H, Tsukushi S, Ito Y
  • Journal Title: Internal Medicine Volume: 54 Issue: 5 Pages: 481-485
  • DOI: 10.2169/internalmedicine.54.2967
  • NAID: 130004724006
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Long-term effects of spironolactone in peritoneal dialysis patients. (2014)
  • Author(s): Ito Y, Mizuno M, Suzuki Y, Tamai G, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S, Nagoya Spiro Study Group.
  • Journal Title: Journal of American Society of Nephrology Volume: 24 Pages: 1627-1642
  • Peer Reviewed
• [Journal Article] Smoking is a risk factor for the progression of idiopathic membranous nephropathy. (2014)
  • Author(s): Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
  • Journal Title: PLoS One. Volume: 9 Issue: 6 Pages: e100835-e100835
  • DOI: 10.1371/journal.pone.0100835
  • Peer Reviewed / Open Access
• [Journal Article] Successful treatment of Cryptococcus laurentii peritonitis in a patient on peritoneal dialysis. (2014)
  • Author(s): Asano M, Mizutani M, Nagahara Y, Inagaki K, Kariya T, Masamoto D, Urai M, Kaneko Y, Ohno H, Miyazaki Y, Mizuno M, Ito Y
  • Journal Title: Internal Medicine Volume: Epub
  • NAID: 130005065248
  • Peer Reviewed
• [Journal Article] The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. (2014)
  • Author(s): Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y, Kosugi T, Kato S, Tsuboi N, Sato W, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S
  • Journal Title: Acta cardiologica Volume: Epub .
  • Peer Reviewed
• [Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients. (2014)
  • Author(s): Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
  • Journal Title: Journal of the American Society of Nephrology Volume: -
  • Peer Reviewed
• [Journal Article] Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation. (2013)
  • Author(s): Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y ,Maruyama S1.
  • Journal Title: Cytotherapy. Volume: 16(3) Issue: 3 Pages: 357-68
  • DOI: 10.1016/j.jcyt.2013.10.011
  • Peer Reviewed
• [Journal Article] Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59. (2013)
  • Author(s): Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 305(11) Issue: 11 Pages: 1603-1616
  • DOI: 10.1152/ajprenal.00681.2012
  • Peer Reviewed
• [Journal Article] Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. (2013)
  • Author(s): Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.
  • Journal Title: Internal Medicine Volume: 52 Pages: 1177-1181
  • NAID: 130003365636
  • Peer Reviewed
• [Journal Article] TGF-β1 Promotes Lymphangiogenesis during Peritoneal Fibrosis. (2013)
  • Author(s): Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.
  • Journal Title: J Am Soc Nephrol. Volume: 24 Issue: 10 Pages: 1627-1642
  • DOI: 10.1681/asn.2012030226
  • Peer Reviewed
• [Journal Article] A case report: perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. (2013)
  • Author(s): Mizuno M., Suzuki Y., Nonaka K., Sei Y., Maruyama S., Matsuo S., Ito Y.
  • Journal Title: Internal Medicine Volume: inpress
  • Peer Reviewed
• [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. (2013)
  • Author(s): Katsuno T
  • Journal Title: Cell Transplant Volume: 22(2) Issue: 2 Pages: 287-97
  • DOI: 10.3727/096368912x655019
  • Peer Reviewed
• [Journal Article] Guideline for hereditary angioedema (HAE) 2010 by the Japanese association for complement research. (2012)
  • Author(s): Horiuchi T, Ohi H, Ohsawa I, Fujita T, Matsushita M, Okada N, Seya T, Yamamoto T, Endo Y, Hatanaka M, Wakamiya N, Mizuno M, Nakao M, Okada H,他5名.
  • Journal Title: Allergy Int. Volume: Vol. 61 Pages: 559-562
  • Peer Reviewed
• [Journal Article] Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomu in elderly patients. (2012)
  • Author(s): Mizuno T., Ito K., Miyagawa Y., Ishikawa K., Suzuki Y., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Yamada K., Noda Y.
  • Journal Title: Jpn J Clin Oncol. Volume: Vol.42 Issue: 11 Pages: 1073-1078
  • DOI: 10.1093/jjco/hys145
  • Peer Reviewed
• [Journal Article] Exploiting the nephrotoxic effects of venom from the sea anemone, Phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat. (2012)
  • Author(s): Mizuno M., Ito Y, Morgan BP.
  • Journal Title: Marine Drugs Volume: Vol.10 Issue: 7 Pages: 136-143
  • DOI: 10.3390/md10071582
  • Peer Reviewed
• [Journal Article] Combined Values of Serum Albumin, C-Reactive Protein and Body Mass Index at Dialysis Initiation Accurately Predicts Long-Term Mortality. (2012)
  • Author(s): Takahashi R
  • Journal Title: Am J Nephrol Volume: 36(2) Issue: 2 Pages: 136-143
  • DOI: 10.1159/000339940
  • Peer Reviewed
• [Journal Article] A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. (2012)
  • Author(s): Ito I
  • Journal Title: Clin Exp Nephrol Volume: 16(3) Issue: 3 Pages: 490-4
  • DOI: 10.1007/s10157-012-0620-8
  • Peer Reviewed
• [Journal Article] Membrane complement regulators protect against fibrin exudation in a severe peritoneal inflammation model in rats. (2012)
  • Author(s): Mizuno M., Ito Y., Mizuno T., Suzuki Y., Harris CL., Okada N, Matsuo S, Morgan BP.
  • Journal Title: Am J Physil Renal Physiol Volume: 302
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction (2012)
  • Author(s): Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y
  • Journal Title: Kidney Int. Volume: (印刷中)(未定) Issue: 9 Pages: 865-79
  • DOI: 10.1038/ki.2011.464
  • Peer Reviewed
• [Journal Article] Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model (2012)
  • Author(s): Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y
  • Journal Title: Nephrol.Dial.Transplant. Volume: Vol.27 Issue: 2 Pages: 526-536
  • DOI: 10.1093/ndt/gfr302
  • Peer Reviewed
• [Presentation] Level of soluble C5b-9 complex in dialysis fluid may be a predictor of poor prognosis in peritonitis in peritoneal dialysis patients, especially in culture negative peritonitis. (2014)
  • Author(s): Mizuno M、Ito Y., Higashide K., Sei Y., Iguchi D., Sakata F., Suzuki Y., Ito I., Horie M., Morgan BP., Matsuo S
  • Organizer: The XXV International complement workshop
  • Place of Presentation: Rio de Janeiro, RJ（Brazil）
  • Year and Date: 2014-09-16
• [Presentation] 東海地区の15施設における2010年1月から3年間の腹膜透析（PD）の調査～東海PDレジストリ2～ (2014)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、丸山彰一、松尾清一、名大PDレジストリ 研究グループ
  • Organizer: 第20回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 山形国際ホテル(山形県山形市)
  • Year and Date: 2014-09-06 – 2014-09-07
• [Presentation] 腹膜透析排出液中の補体活性化産物測定により、腹膜炎の予後を予測できるか? (2014)
  • Author(s): 水野正司、伊藤恭彦、東出慶子、清祐実、井口大旗、坂田史子、鈴木康弘、堀江正宣、B.Paul Morgan、伊藤功、松尾清一
  • Organizer: 第51回補体シンポジウム
  • Place of Presentation: 神戸常磐大学(兵庫県神戸市)
  • Year and Date: 2014-08-22 – 2014-08-23
• [Presentation] 腹膜透析患者由来ヒト腹膜中皮細胞における膜補体制御因子の解析 (2014)
  • Author(s): 清祐実、水野正司、井口大旗、東出慶子、鈴木康弘、今井優樹、松尾清一、伊藤恭彦
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 東海腹膜透析(PD)レジストリ2～5年後の離脱と腹膜炎についての調査～. (2014)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、丸山彰一、松尾清一、坂洋祐、平松武幸、玉井宏史、水谷真、成瀬友彦、大橋徳巳、春日弘毅、清水秀明、倉田久嗣、倉田圭、鈴木聡、鶴田吉和、松岡哲平、堀江正宣
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] Improvement of prevalence of peritoneal dialysis (PD) therapy in end-stage renal disease (ESRD) patients from 2010 to 2012 in the Tokai area of Japan; Five years after the previous study. (2014)
  • Author(s): Mizuno M, Ito Y., Suzuki Y., Saka Y., Hitamatsu T., Tamai H., Mizutani M., Naruse T., Ohashi N., Kasuga H., Shimizu H., Kurata H., Kurata K., Suzuki S., Maruyama S., Matsuo S
  • Organizer: The 14th Asian Pacific Congress of Nephrology
  • Place of Presentation: 品川プリンスホテル(東京都港区)
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] Expression of membrane complement regulators in mesothelial cells of patients’ peritoneum on peritoneal dialysis therapy. (2014)
  • Author(s): Sei Y., MizunoM., Suzuki Y., Imai M., Higashide K., Sakata F., Iguchi D., Okada N., Matsuo S., Ito Y.
  • Organizer: The 14th Asian Pacific Congress of Nephrology
  • Place of Presentation: 品川プリンスホテル(東京都港区)
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] BENEFICIAL EFFECT OF CONTINUOUS ERYTHROPOIETIN RECEPTOR ACTIVATOR (C.E.R.A.) IN CAPD PATIENTS. (2013)
  • Author(s): Yasuhiro Suzuki, Yasuhiko Ito, Masashi Mizuno, Hideki Hiramatsu, Hiroshi Kinashi, Humiko Nagura, Takeshi Terabayashi, Yumi Sei, Takako Tomita, Shoichi Maruyama, Seiichi Matsuo.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国)
• [Presentation] RAT ADIPOSE TISSUE-DERIVED STROMAL CELLS ATTENUATE PERITONEAL INJURIES IN RAT ZYMOSAN-INDUCED PERITONITIS ACCOMPANIED BY COMPLEMENT ACTIVATION. (2013)
  • Author(s): Hangsoo Kim, Masashi Mizuno, Kazuhiro Furuhashi, Takayuki Katsuno, Takenori Ozaki, Kaoru Yasuda, Naotake Tsuboi, Yasuhiko Ito, Shoichi Maruyama, Matsuo Seiichi.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国)
• [Presentation] Expression of membrane complement regulators in end stage renal disease patients on peritoneal dialysis therapy. (2013)
  • Author(s): Yumi Sei, Masashi Mizuno, Yasuhiro Suzuki, Masaki Imai, Keiko Higashide, Claire L Harris, Seiichi Matsuo,Yasuhiko Ito
  • Organizer: 14th European Meeting on Complement in Human Disease
  • Place of Presentation: イエーナ(ドイツ)
• [Presentation] The continuous erythropoietin receptor activator (C.E.R.A.) maintains renal anemia safely at extended administration intervals in CAPD patients. (2013)
  • Author(s): Takako Tomita, Yasuhiro Suzuki, Yasuhiko Ito, Masashi Mizuno, Hiroshi Kinashi, Humiko Sakata, Takeshi Terabayashi, Yumi Sei, Shoichi Maruyama and Seiichi Matsuo.
  • Organizer: 6th International Society for Peritoneal Dialysis - Asia Pacific Chapter Meeting, ISPD-APCM
  • Place of Presentation: 台北(中国)
• [Presentation] Spironolactone Prevents Cardiac Hypertrophy in Peritoneal Dialysis Patients without Significant Adverse Effects. (2013)
  • Author(s): Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Hirotake Kasuga, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo.
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta(USA)
• [Presentation] ワークショップ2 基礎から臨床につながる補体学 (2013)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、清祐実、丸山彰一、松尾清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] Zymosan投与により誘導される補体依存性腹膜炎モデルに対する脂肪由来間葉系幹細胞の有用性 (2013)
  • Author(s): 金恒秀、水野正司、古橋和拡、勝野敬之、安田香、尾崎武徳、坪井直毅、伊藤恭彦、松尾清一、丸山彰一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 腎代替療法における補体の関わり (2013)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、清祐実、丸山彰一、松尾清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] ミネラロコルチコイド受容体(MR)拮抗薬の腹膜透析患者の心・腹膜・残腎機能への効果 (2013)
  • Author(s): 伊藤恭彦、水野正司、玉井宏史、平松武幸、大橋宏重、伊藤功、春日弘毅、丸山彰一、松尾清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 急性腹膜組織障害へのC5aの関与と抗補体療法の可能性 (2013)
  • Author(s): 水野 智博、水野正司、鈴木康弘、清祐実、富田貴子、寺林武、鬼無洋、丸山彰一、松尾清一、伊藤恭彦
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 名古屋大学関連施設レジストリーからみた現在の腹膜透析の問題点とその対策 (2013)
  • Author(s): 伊藤恭彦、水野正司、鈴木康弘、松尾清一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
• [Presentation] Fabry病による慢性腎不全で長期に安定した腹膜透析(PD)施行中の一例 (2013)
  • Author(s): 武藤玲子、勝野敬之、鈴木康弘、安田香、尾崎武徳、小杉智規、安田宜成、佐藤和一、坪井直毅、水野正司、伊藤恭彦、丸山彰一、松尾清一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際センター(福岡市)
• [Presentation] 腹膜透析患者におけるC.E.R.A投与の検討 (2013)
  • Author(s): 鈴木康弘、勝野敬之、安田香、尾崎武徳、小杉智規、佐藤和一、坪井直毅、水野正司、丸山彰一、伊藤恭彦、松尾清一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
• [Presentation] 腹膜透析(PD)導入時に、高度の好酸球性腹膜炎にステロイド治療が有効であった一例 (2013)
  • Author(s): 水野正司、鈴木康弘、勝野敬之、尾崎武徳、佐藤和一、坪井直毅、丸山彰一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: マリンメッセ福岡(福岡市)
• [Presentation] PD患者における在宅への関わりについて (2013)
  • Author(s): 本村良美、服部祐子、酒井知子、水野正司、伊藤恭彦
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: マリンメッセ福岡(福岡市)
• [Presentation] PD患者由来ヒト腹膜中皮細胞における膜補体制御因子の解析 (2013)
  • Author(s): 清祐実、水野正司、今井優樹、Claire L. Harris、松尾清一、伊藤恭彦
  • Organizer: 第50回補体シンポジウム
  • Place of Presentation: 旭川医科大学(旭川市)
• [Presentation] Zymosan（Z）誘導ラット腹膜炎モデルにおける膜補体制御因子（R）の重要性と腹膜傷害に補体活性化異常が及ぼす影響
  • Author(s): 水野正司、伊藤恭彦、水野智博、鈴木康弘、鬼無洋、名倉史子、清祐実、寺林武、岡田則子、松尾清一
  • Organizer: 第57回 日透析医学会学術集会・総会
  • Place of Presentation: 京王プラザホテル札幌(札幌)
• [Presentation] 腹膜擦過後のZymosan投与により誘導される補体依存性腹膜炎モデルに対する低血清培養脂肪由来間葉系幹細胞の有用性
  • Author(s): 金恒秀、水野正司、古橋和拡、勝野敬之、安田香、尾崎武徳、坪井 直毅、佐藤和一、今井圓裕、伊藤恭彦、松尾 清一、丸山 彰一
  • Organizer: 第57回 日透析医学会学術集会・総会
  • Place of Presentation: 札幌市文化会館(札幌)
• [Presentation] 補体活性を介した急性腹膜障害に対するC5a, C5aRの関与
  • Author(s): 水野智博、水野正司、櫛田真由、野田幸裕、今井優樹、岡田秀親、岡田則子、丸山彰一、松尾清一、伊藤恭彦
  • Organizer: 第57回 日透析医学会学術集会・総会
  • Place of Presentation: 京王プラザホテル札幌(札幌)
• [Presentation] 急性腹膜障害に対するアンチセンスC5aペプチドの治療効果
  • Author(s): 水野智博、水野正司、櫛田真由、野田幸裕、今井優樹、岡田秀親、岡田則子、丸山彰一、松尾清一、伊藤恭彦
  • Organizer: 第49回 補体シンポジウム
  • Place of Presentation: 大阪成人病センター(大阪)
• [Presentation] 急性腹膜障害に対するC5aの関与と抗補体療法の検討
  • Author(s): 水野智博、水野正司、鈴木康弘、櫛田真由、野田幸裕、丸山彰一、今井圓裕、松尾清一、伊藤恭彦
  • Organizer: 第18回 日本腹膜透析学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
• [Presentation] C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats.
  • Author(s): Mizuno T., Mizuno M, Imai M., Suzuki Y., Kushida M., Yamada K., Noda Y., Maruyama S., Okada H., Okada N., Matsuo S., Ito Y.
  • Organizer: XXIII International complement workshop
  • Place of Presentation: Crete(ギリシャ)
• [Presentation] Rat adipose tissue-derived stromal cells in a low serum medium attenuate peritoneal injuries in rat zymozan-induced peritonitis.
  • Author(s): Kim H., Mizuno M., Furuhashi K., Katsuno T., Ozaki T., Yasuda K., Tsuboi N., Imai E., Matsuo S., Ito Y., Maruyama S.
  • Organizer: XXIII International complement workshop
  • Place of Presentation: Crete(ギリシャ)
• [Book] 最新医学・別冊 新しい診断と治療のABC 80, ネフローゼ症候群, 第2章病理・病態生理, 病因5. 膜性増殖性糸球体腎炎II型 (2013)
  • Author(s): 今井圓裕、杉山斉、長田道夫、丸山影一、山縣邦弘、篠原明成、横山仁、金子佳腎、水野正司、金崎啓造、山端潤也、猪阪善隆、湯沢由紀夫、今田恒夫、藤元昭一、奥田拓史、寺西順哉、岩野正之、佐藤博 他
  • Total Pages: 268
  • Publisher: 最新医学社