New therapeutic target of lymphangiogenesis on ultrafiltration failure in PD and on chronic kidney diseases
Project/Area Number |
24591228
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Nagoya University |
Principal Investigator |
ITO yasuhiko 名古屋大学, 医学(系)研究科(研究院), 教授 (60402632)
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Co-Investigator(Kenkyū-buntansha) |
MIZUNO Masashi 名古屋大学, 大学院医学系研究科, 寄附講座准教授 (20303638)
SUZUKI Yasuhiro 名古屋大学, 大学院医学系研究科, 寄附座助教 (20584676)
TAKEI Yoshifumi 名古屋大学, 大学院医学系研究科, 准教授 (70362233)
MATSUO Seiichi 名古屋大学, 大学院医学系研究科, 教授 (70190410)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 腹膜透析 / VEGF-C / リンパ管 / VEGF-D / 線維化 / 除水不全 / VEGFR-3 / TGF-b / 腹膜透過性 / 腎間質障害 |
Outline of Final Research Achievements |
Appropriate fluid balance is important for good clinical outcomes and survivals in patients on peritoneal dialysis (PD). We studied the roles of lymphangiogenesis and vascular endothelial growth factor-C and -D (VEGF-C and -D), a potentially important mediator of lymphangiogenesis, in the relationship between peritoneal fibrosis and ultrafiltration failure using human dialysate effluents, human peritoneal tissues, human peritoneal mesothelial cells obtained from spent patient peritoneal dialysates, and rodent peritoneal fibrosis models. We demonstrated that lymphangiogenesis is a common feature, and is developed mainly in the diaphragm. Lymphangiogenesis is associated with fibrosis via the TGF-b-VEGF-C pathway, and VEGF-D also plays an important role in the development of lymphangiogenesis. We showed that suppression of lymphatic absorption can improve the net ultrafiltration in PD.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy.2015
Author(s)
Sei Y, Mizuno M, Suzuki Y, Imai M, Higashide K, Harris CL, Sakata F, Iguchi D, Fujiwara M, Kodera Y, Maruyama S, Matsuo S, Ito Y
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Journal Title
Molecular Immunology
Volume: 153
Issue: 2
Pages: 302-309
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morphological caracteristics in peritoneum in patients with neutral peritoneal dialysis solution.2015
Author(s)
Hamada C, Honda K, Kawanishi K, Nakamoto H, Ito Y, Sakurada T, Tanno Y, Mizumasa T, Miyazaki M, Moriishi M, Nakayama M
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Journal Title
Journal of Artifical Organs(in press 2015)
Volume: Epub
Issue: 3
Pages: 243-250
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term effects of Spironolactone in peritoneal dialysis patients.2014
Author(s)
Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S, Nagoya Spiro Study Group
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Journal Title
Journal of the American society of nephrology
Volume: 25(5)
Pages: 1094-1102
Related Report
Peer Reviewed
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[Journal Article] Successful treatment of Cryptococcus laurentii peritonitis in a patient on peritoneal dialysis.2014
Author(s)
Asano M, Mizutani M, Nagahara Y, Inagaki K, Kariya T, Masamoto D, Urai M, Kaneko Y, Ohno H, Miyazaki Y, Mizuno M, Ito Y
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Journal Title
Internal Medicine(in press 2014)
Volume: Epub
NAID
Related Report
Peer Reviewed
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[Journal Article] Smoking is a risk factor for the progression of ideopathic membranous nephropathy.2014
Author(s)
Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S
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Journal Title
PLOS ONE
Volume: 9(6)
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients.2014
Author(s)
Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
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Journal Title
J Am Soc Nephrol.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation.2013
Author(s)
Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y ,Maruyama S1.
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Journal Title
Cytotherapy.
Volume: 16(3)
Issue: 3
Pages: 357-68
DOI
Related Report
Peer Reviewed
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[Journal Article] Geriatric nutritional risk index accurately predicts cardiovascular mortality in incident hemodialysis patients.2013
Author(s)
Takahashi H, Ito Y, Ishii H, Aoyama T, Kamoi D, Kasuga H, Yasuda K, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
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Journal Title
J Cardiol.
Volume: S0914-5087(13)
Issue: 1
Pages: 352-3
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of cardiac valvular calcifications and C-reactive protein with cardiovascular mortality in incident hemodialysis patients: a Japanese cohort study.2013
Author(s)
Takahashi H, Ishii H, Aoyama T, Kamoi D, Kasuga H, Ito Y, Yasuda K, Tanaka M, Yoshikawa D, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
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Journal Title
Am J Kidney Dis
Volume: 61(2)
Issue: 2
Pages: 254-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59.2013
Author(s)
Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.
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Journal Title
Am J Physiol Renal Physiol.
Volume: 305(11)
Issue: 11
Pages: 1603-1616
DOI
Related Report
Peer Reviewed
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[Journal Article] TGF-β1 Promotes Lymphangiogenesis during Peritoneal Fibrosis.2013
Author(s)
Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.
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Journal Title
J Am Soc Nephrol.
Volume: 24
Issue: 10
Pages: 1627-1642
DOI
Related Report
Peer Reviewed
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[Journal Article] Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction2012
Author(s)
Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y
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Journal Title
Kidney Int.
Volume: (印刷中)(未定)
Issue: 9
Pages: 865-79
DOI
Related Report
Peer Reviewed
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[Journal Article] Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomu in elderly patients.2012
Author(s)
Mizuno T., Ito K., Miyagawa Y., Ishikawa K., Suzuki Y., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Yamada K., Noda Y.
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Journal Title
Jpn J Clin Oncol.
Volume: Vol.42
Issue: 11
Pages: 1073-1078
DOI
Related Report
Peer Reviewed
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[Presentation] Levels of soluble C5B-9 complex fluid may be a predictor of poor prognosis in peritonitis in peritoneal dialysis patients, especially in culture negative peritonitis2014
Author(s)
Mizuno M, Ito Y, Higashide K, Sei Y, Iguchi D, Sakata F, Suzuki Y, Ito I, Horie M, Morgan BP, Matsuo S
Organizer
XXV International Complement Workshop
Place of Presentation
Brazil,Rio de Janeiro
Year and Date
2014-09-14 – 2014-09-18
Related Report
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[Presentation] Calcified amorphous tumor of the heart in a peritoneal dialysis patient2014
Author(s)
Tanaka A, Mizuno M, Sakata F, Suzuki Y, Ohshima H, Ishikawa H, Tsukushi S, Maruyama S, Matsuo S, Ito Y
Organizer
15th Congress of the International Society for Peritoneal Dialysis
Place of Presentation
Spain,Madrid
Year and Date
2014-09-07 – 2014-09-10
Related Report
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[Presentation] より長期の腹膜透析療法を目指して2014
Author(s)
伊藤恭彦
Organizer
第59回日本透析医学会学術集会・総会
Place of Presentation
神戸ポートピアホテル(兵庫県神戸市)
Year and Date
2014-06-12 – 2014-06-15
Related Report
Invited
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[Presentation] Lymphangiogenesis develops during peritoneal fibrosis in rat peritonitis models2014
Author(s)
Terabayashi T, Ito Y, Kinashi H, Mizuno M, Suzuki Y, Sakata F, Tomita T, Tawada M, Sei Y, Iguchi D, Matsuo S
Organizer
The 14th Asian Pacific Congress of Nephrology
Place of Presentation
Shinagawa Prince Hotel(東京都港区)
Year and Date
2014-05-14 – 2014-05-17
Related Report
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[Presentation] BENEFICIAL EFFECT OF CONTINUOUS ERYTHROPOIETIN RECEPTOR ACTIVATOR (C.E.R.A.) IN CAPD PATIENTS.2013
Author(s)
Yasuhiro Suzuki, Yasuhiko Ito, Masashi Mizuno, Hideki Hiramatsu, Hiroshi Kinashi, Fumiko Nagura, Takeshi Terabayashi, Yumi Sei, Takako Tomita, Shoichi Maruyama, Seiichi Matsuo.
Organizer
The World Congress of Nephrology 2013
Place of Presentation
香港(中国)
Related Report
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[Presentation] Serum Beta-2 Microglobulin Significantly Predicts Survival in Association with the Residual Renal Function in Japanese Patients on Peritoneal Dialysis – A Prospective Multicenter Cohort Study (PDR-CS).2013
Author(s)
Hiroshi Morinaga, Hitoshi Sugiyama, Yasuhiko Ito, Kazuhiko Tsuruya, Hisako Yoshida, Hiroki Maruyama, Shin Goto, Tomoya Nishino, Hiroyuki Terawaki, Masaaki Nakayama, Hidetomo Nakamoto, Seiichi Matsuo, Hirofumi Makino
Organizer
Kidney Week 2013
Place of Presentation
Atlanta(USA)
Related Report
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