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Evaluation of mechanisms of uremic toxin induced wasting and the therapeutic application

Research Project

Project/Area Number 24591230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionShimane University

Principal Investigator

YANO SHOZO  島根大学, 医学部, 准教授 (80403450)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords尿毒素 / 蛋白エネルギー消費 / インスリン抵抗性 / 腎不全
Outline of Final Research Achievements

Patients with chronic kidney disease (CKD) are characterized by wasting or catabolic state in parallel with the disease progression, which may be associated with an increased risk of cardiovascular events and mortality. “Uremic toxin” accumulated in advanced CKD may be responsible for the disturbance of insulin action in this pathophysiology. Number of substances are known as a uremic toxin, most of which are produced by the gut microbiota. We showed that uremic toxins are involved in the disturbance of insulin action and catabolic state of CKD, and thus the development of an efficient removal technology is required.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (7 results) Book (11 results)

  • [Journal Article] A carboxylated Zn-phthalocyanine inhibits fibril formation of Alzheimer’s amyloid β peptide.2015

    • Author(s)
      Tabassum S, Sheikh AM, Yano S. Ikeue T, Handa M, Nagai A
    • Journal Title

      FEBS J

      Volume: 282 Issue: 3 Pages: 463-476

    • DOI

      10.1111/febs.13151

    • NAID

      120006309236

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Uremic Toxin p-Cresol on Proliferation, Apoptosis, Differentiation, and Glucose Uptake in 3T3-L1 Cells.2014

    • Author(s)
      Tanaka S, Yano S, Sheikh AM, Nagai A, Sugimoto T
    • Journal Title

      Artif Organs

      Volume: 印刷中 Issue: 7 Pages: 566-571

    • DOI

      10.1111/aor.12252

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Close Relationship between Serum Hyaluronan Levels and Vascular Function in Patients with Type 2 Diabetes.2014

    • Author(s)
      Morita M, Yano S, Ishibashi Y, Nakata N, Kurioka S, Sugimoto T
    • Journal Title

      Biomarkers

      Volume: 19 Issue: 6 Pages: 493-497

    • DOI

      10.3109/1354750x.2014.940502

    • NAID

      120005982751

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasma arginine/ADMA ratio as a sensitive risk marker for atherosclerosis:Shimane CoHRE Study.2014

    • Author(s)
      Notsu Y, Yano S, Shibata H, Nagai A, Nabika T
    • Journal Title

      Atherosclerosis

      Volume: 239 Issue: 1 Pages: 61-66

    • DOI

      10.1016/j.atherosclerosis.2014.12.030

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Advanced glycation end-products-induced vascular calcification is mediated by oxidative stress: functional roles of NAD(P)H-oxidase.2013

    • Author(s)
      1. Tada Y, Yano S, Okazaki K, Ogawa N, Morita M, Kanazawa I, Yamaguchi T, Sugimoto T.
    • Journal Title

      Horm Metab Res

      Volume: 45 Issue: 04 Pages: 267-272

    • DOI

      10.1055/s-0032-1329965

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト血管平滑筋細胞のアポトーシスと石灰化形成に関する検討2014

    • Author(s)
      長崎雅幸,矢野彰三,松本健一,織田禎二,原田祐治,三島清司,長井 篤
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎・心血管障害進展指標としてのArginine/ADMA比の有用性:Shimane CoHRE Study2014

    • Author(s)
      野津吉友,矢野彰三,長井 篤,並河 徹
    • Organizer
      第54回日本臨床化学会年次学術集会
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 動脈硬化症と骨代謝との関連:Shimane CoHRE Study2014

    • Author(s)
      矢野彰三,並河 徹,長井 篤,杉本利嗣
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 透析患者の骨強度を維持するには~5年間の骨量計測結果からの考察~2014

    • Author(s)
      矢野彰三,公受伸之,鈴木恵子,杉本利嗣
    • Organizer
      第59回日本透析医学会学術集会・総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-06-12 – 2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of uremic toxin p-cresylsulfate on insulin resistance in adipocytes.2014

    • Author(s)
      Tanaka S, Yano S, Sugimoto T
    • Organizer
      The 51st ERA-EDTA congress
    • Place of Presentation
      Amsterdam, Holand
    • Year and Date
      2014-05-31 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of uremic toxin p-cresylsulfate on insulin resistance in adipocytes.2014

    • Author(s)
      Sayuri Tanaka, Shozo Yano, Toshitsugu Sugimoto
    • Organizer
      The 51th ERA-EDTA congress
    • Place of Presentation
      Amsteldam
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of uremic toxin p-cresol on proliferation, apoptosis, differentiation and glucose uptake in 3T3-L1 cells2013

    • Author(s)
      Tanaka S, Yano S, and Sugimoto T
    • Organizer
      The 50th ERA-EDTA congress
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2012 Research-status Report
  • [Book] 今日の治療指針 2016年度版2016

    • Author(s)
      矢野彰三
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] Pocket Drugs 20152015

    • Author(s)
      矢野彰三, 杉本利嗣
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 島大病院ちょっと気になる健康講座2015

    • Author(s)
      矢野彰三
    • Total Pages
      153
    • Publisher
      今井出版
    • Related Report
      2014 Annual Research Report
  • [Book] 日常診療のための検査値のみかた2015

    • Author(s)
      矢野彰三, 杉本利嗣
    • Total Pages
      757
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] ファーマナビゲーターシリーズ/糖尿病と骨代謝編2015

    • Author(s)
      矢野彰三
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 内分泌代謝疾患クリニカルクエスチョン1002014

    • Author(s)
      矢野彰三, 杉本利嗣
    • Total Pages
      183
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] Pocket Drugs 20142014

    • Author(s)
      矢野彰三, 杉本利嗣
    • Total Pages
      1285
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] CKD-MBDハンドブック 第2版2013

    • Author(s)
      矢野彰三
    • Total Pages
      325
    • Publisher
      日本メディカルセンター
    • Related Report
      2013 Research-status Report
  • [Book] 透析患者の検査値の読み方 改訂第3版2013

    • Author(s)
      矢野彰三
    • Total Pages
      461
    • Publisher
      日本メディカルセンター
    • Related Report
      2013 Research-status Report
  • [Book] 慢性腎臓病に伴う骨ミネラル代謝異常(CKD-MBD)ガイドラインサポートハンドブック 改訂版2013

    • Author(s)
      矢野彰三
    • Total Pages
      334
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Research-status Report
  • [Book] 医師・薬剤師のための医薬品副作用ハンドブック2013

    • Author(s)
      矢野彰三, 杉本利嗣
    • Total Pages
      613
    • Publisher
      日本臨床
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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