Evaluation of mechanisms of uremic toxin induced wasting and the therapeutic application
| Project/Area Number |
24591230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Shimane University |
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Principal Investigator |
YANO SHOZO 島根大学, 医学部, 准教授 (80403450)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 尿毒素 / 蛋白エネルギー消費 / インスリン抵抗性 / 腎不全 |
|---|
| Outline of Final Research Achievements |
Patients with chronic kidney disease (CKD) are characterized by wasting or catabolic state in parallel with the disease progression, which may be associated with an increased risk of cardiovascular events and mortality. “Uremic toxin” accumulated in advanced CKD may be responsible for the disturbance of insulin action in this pathophysiology. Number of substances are known as a uremic toxin, most of which are produced by the gut microbiota. We showed that uremic toxins are involved in the disturbance of insulin action and catabolic state of CKD, and thus the development of an efficient removal technology is required.
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Report
(4 results)
Research Products
(23 results)
